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Induced Pluripotent Stem Cells
To facilitate research on differentiated cell types and other biomedical investigations, the NIGMS Repository offers human induced pluripotent stem cell (hiPSC) lines derived from apparently healthy individuals or from individuals affected with heritable diseases. These hiPSCs were created using a variety of reprogramming techniques*.
Some of the available hiPSC lines were derived from externally submitted iPSC lines, where a distribution stock was made. Others were derived from established LCLs or Fibroblast lines available in the catalog. In addition to QC tests (viability, contamination, karyotyping, microarray genotyping, and microsatellite matches with the parent cell culture), extensive pluripotency characterizations are performed on each NIGMS Repository hiPSC line. Pluripotency characterizations include the following assays:
Surface antigen expression
Embryoid body formation
PluriTest gene expression assay
A complete Certificate of Analysis (CofA) that includes images and quantitative test results is available for each hiPSC line. The CofA PDF specifies which pluripotency characterizations were performed on each hiPSC line.
The Protocol PDFs outline the proper steps for successful handling of the hiPSCs. Additional information is also found on the CofA PDF, including necessary media components, substrates, passage methods, and split ratios.
* For commercial purposes, please note that Limited Use Label Licenses (LULLs) may apply.
Apparently Healthy hiPSC Lines
Records Return:
(22)
Show
5
10
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50
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200
500
1
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Catalog ID
Description
Parent Line
Transformant
LULL
Gender
Age
Race
Biopsy Source
Affected Status
Related Samples
Certificate of Analysis
Protocol
GM23392
APPARENTLY HEALTHY FETAL TISSUE
GM06114
Reprogrammed (Retroviral)
WARF
Male
20 FW
Black/African American
Lung
No
910
CofA PDF
Protocol PDF
GM23396
APPARENTLY HEALTHY FETAL TISSUE
GM06111
Reprogrammed (Retroviral)
WARF
Female
16 FW
Black/African American
Skin
No
911
CofA PDF
Protocol PDF
GM23413
APPARENTLY HEALTHY FETAL TISSUE
GM06112
Reprogrammed (Retroviral)
WARF
Female
16 FW
Black/African American
Lung
No
911
CofA PDF
Protocol PDF
GM23450
APPARENTLY HEALTHY FETAL TISSUE
GM06113
Reprogrammed (Retroviral)
WARF
Male
20 FW
Black/African American
Skin
No
910
CofA PDF
Protocol PDF
GM23716
APPARENTLY HEALTHY FETAL TISSUE
GM06111
Reprogrammed (Episomal)
WARF
Female
16 FW
Black/African American
Skin
No
911
CofA PDF
Protocol PDF
GM23279
APPARENTLY HEALTHY INDIVIDUAL
Not in Repository
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Female
36 YR
White
Skin
No
2997
CofA PDF
Protocol PDF
GM23476
APPARENTLY HEALTHY INDIVIDUAL
GM04506
Reprogrammed (Lentiviral)
WARF
Female
20 YR
White
Skin
No
732
CofA PDF
Protocol PDF
GM23720
APPARENTLY HEALTHY INDIVIDUAL
GM02254
Reprogrammed (Episomal)
WARF
Female
22 YR
White
Peripheral vein
No
3045
CofA PDF
Protocol PDF
GM25256
APPARENTLY HEALTHY INDIVIDUAL
WTC11 (6W JY)
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
30 YR
Asian
Skin
No
3181
CofA PDF
Protocol PDF
GM25430
APPARENTLY HEALTHY INDIVIDUAL
CV-B
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Male
62 YR
White
Skin
No
3238
CofA PDF
Protocol PDF
GM27717
APPARENTLY HEALTHY INDIVIDUAL
GM03524
Reprogrammed (Sendai)
Sendai-Cyto Tune
Female
67 YR
Black/African American
Skin
No
CofA PDF
Protocol PDF
GM28404
APPARENTLY HEALTHY INDIVIDUAL
GM03234
Reprogrammed (Sendai)
Sendai-Cyto Tune
Male
23 YR
American Indian/Alaska Native
Skin
No
CofA PDF
Protocol PDF
GM28907
APPARENTLY HEALTHY INDIVIDUAL
GM07532
Reprogrammed (Sendai)
Sendai-Cyto Tune
Female
16 YR
Other
Skin
No
1057
CofA PDF
Protocol PDF
GM28978
APPARENTLY HEALTHY INDIVIDUAL
GM00726
Reprogrammed (Sendai)
Sendai-Cyto Tune
Female
26 YR
Asian
Skin
No
CofA PDF
Protocol PDF
GM23338
PERSONAL GENOME PROJECT
GM23248
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Male
55 YR
White
Skin
No
2980
CofA PDF
Protocol PDF
GM26077
PERSONAL GENOME PROJECT
GM24143
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Female
74 YR
White
Unknown
3140
CofA PDF
Protocol PDF
GM26105
PERSONAL GENOME PROJECT
GM24385
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
45 YR
White
Unknown
3140
CofA PDF
Protocol PDF
GM26107
PERSONAL GENOME PROJECT
GM24631
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
33 YR
Asian
Unknown
3150
CofA PDF
Protocol PDF
GM27730
PERSONAL GENOME PROJECT
GM27908
Reprogrammed (Sendai)
Sendai-Cyto Tune
Male
45 YR
White
Unknown
3140
CofA PDF
Protocol PDF
GM29085
PERSONAL GENOME PROJECT
GM24694
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
64 YR
Chinese
Peripheral vein
Unknown
3150
CofA PDF
Protocol PDF
Disease-Specific hiPSC Lines
Records Return:
(135)
Show
>
5
10
20
50
100
200
500
1
2
3
4
5
6
7
Catalog ID
Diagnosis
Parent Line
Transformant
Gender
LULL
Age
Race
Biopsy Source
Affected Status
Gene(s)
Mutation(s)
Family and Associated Specimens
Certificate of Analysis
Protocol
GM28559
ALAGILLE SYNDROME 1; ALGS1
GM11091
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
17 YR
White
Skin
Yes
JAG1
C312X
1324
CofA PDF
Protocol PDF
GM24666
ALZHEIMER DISEASE; AD
SAD 2.2
Reprogrammed (Retroviral)
Male
IP ACADEMIA JAPAN
83 YR
White
Skin
Yes
NQO1 NQO1
c.559C>T (p.P187S)
c.559C>T (p.P187S)
3234
CofA PDF
Protocol PDF
GM24675
ALZHEIMER DISEASE; AD
APP 2.3
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
60 YR
Not Reported
Skin
Yes
APP
Duplication
3236
CofA PDF
Protocol PDF
GM29449
ARGININOSUCCINIC ACIDURIA
GM25500
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
36 YR
White
Blood
Yes
CofA PDF
Protocol PDF
GM29475
ARGININOSUCCINIC ACIDURIA
GM26179
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
15 YR
White
Blood
Yes
ASL ASL ASL ASL
VAL178MET
VAL178MET
ARG193GLN
ARG193GLN
3348
CofA PDF
Protocol PDF
GM29496
BEHCET SYNDROME
GM27138
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
53 YR
White
Yes
CofA PDF
Protocol PDF
GM29484
BETHLEM MYOPATHY
GM27108
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
18 YR
White
Blood
Yes
COL6A1
c.868G>T
3388
CofA PDF
Protocol PDF
GM29488
BETHLEM MYOPATHY
GM27123
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
41 YR
White
Blood
Yes
COL6A1
c.1003-1G>A
CofA PDF
Protocol PDF
GM28249
CANAVAN DISEASE
GM00059
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
1 YR
Not Reported
Skin
Yes
ASPA ASPA ASPA
ALA305GLU
TYR231TER
GLY176ASP
424
CofA PDF
Protocol PDF
GM28915
CANCER OF THE BREAST, FAMILIAL; BCS
GM27953
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
55 YR
White
Blood
Yes
CHEK2
c.190G>A (p.Glu64Lys)
3551
CofA PDF
Protocol PDF
GM29388
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4; CMH4
GM27131
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
29 YR
White
Blood
Yes
MYBPC3
c.1577_1580dupCACT (p.C528TfsX4)
CofA PDF
Protocol PDF
GM29109
CENTRAL CORE DISEASE OF MUSCLE
GM26186
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
61 YR
Other
Blood
Yes
RYR1
ILE4898THR
CofA PDF
Protocol PDF
GM29212
CENTRONUCLEAR MYOPATHY - TYPE UNKNOWN
GM26130
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
3 YR
Asian
Blood
Yes
3334
CofA PDF
Protocol PDF
GM27857
CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1
GM27448
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
4 YR
Asian
Skin
Yes
SLC6A8
DEL EX10-11
3486
CofA PDF
Protocol PDF
GM28937
CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1
GM27863
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
4 YR
White
Blood
Yes
SLC6A8
c.1222_1224DELTTC (p.F408del)
3466
CofA PDF
Protocol PDF
GM28936
CEREBRAL CREATINE DEFICIENCY SYNDROME 2; CCDS2
GM28756
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
18 YR
White
Blood
Yes
GAMT GAMT
c.299_c.311 dup13
c.233T>A
NIGMS00018
CofA PDF
Protocol PDF
GM29115
CEREBRAL CREATINE DEFICIENCY SYNDROME 2; CCDS2
GM27892
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
3 YR
Asiatic Indian
Blood
Yes
GAMT
c.424_426delGAG (p.E142del)
3493
CofA PDF
Protocol PDF
GM28589
CEREBRAL CREATINE DEFICIENCY SYNDROME 3; CCDS3
GM27955
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
18 YR
Asian
Blood
Yes
GATM GATM
IVS3+1G>T (c.484+1G>T)
IVS3+1G>T (c.484+1G>T)
CofA PDF
Protocol PDF
GM27177
CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2
GM20385
Reprogrammed (Episomal)
Female
IP ACADEMIA JAPAN
11 YR
Not Reported
Yes
CLN2 CLN2
IVS5AS, G>C, -1
IVS5-1G>A
3406
CofA PDF
Protocol PDF
GM27465
CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2
GM16485
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
Not Reported
Skin
Yes
CLN2 CLN2
ARG208TER
ARG127TER
3451
CofA PDF
Protocol PDF