Human Induced Pluripotent Stem Cells
The NINDS Repository offers human induced pluripotent stem cell (iPSC) lines to further research on neurological disorders. The iPSC lines were derived from fibroblasts using a variety of reprogramming methods and submitted to the NINDS Repository. Each iPSC line is accompanied by a Certificate of Analysis prepared by the Coriell SCB.

To view whether other biological products from the same subject (such as the parent fibroblast line, lymphoblastoid cell line [LCL] or whole-blood derived DNA) are available for distribution, click on the link in the “Family and Associated Specimens" column of the table. This will direct you to a list of catalog ID numbers that correspond to different biological products derived from the same subject. If additional family members related to the subject are housed within the Repository, they will also be listed here, but will possess a different Family Member ID.

The samples listed in the tables below have been expanded and characterized by the Coriell SCB. The accompanying Certificates of Analysis reflect characterizations and quality testing performed at the Coriell SCB.


CSCB NINDS Repository Human iPS Cell Lines:
Amyotrophic Lateral Sclerosis
Frontotemporal Degeneration
Huntington's Disease
Parkinsonism
Controls

iPSC Spotlight




Amyotrophic Lateral Sclerosis

Catalog IDDiagnosisCell TypeCell SubtypeTransformantGene(s)Mutation(s)GenderAffectedFamily and Associated SpecimensCertificate of AnalysisProtocol
ND35658AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ASN139LYSMaleYes CofA PDFProtocol PDF
ND35659ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ALA4VALFemaleAt Risk CofA PDFProtocol PDF
ND35660AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ASP90ALAFemaleYesNINDS5020CofA PDFProtocol PDF
ND35661AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ILE113THRMaleYesNINDS5022CofA PDFProtocol PDF
ND35662AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 GLU100GLYMaleYesNINDS5025CofA PDFProtocol PDF
ND35663AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) FUS c.1566G>A (p.R522R)FemaleYesNINDS1046CofA PDFProtocol PDF
ND35664AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ASP90ALAFemaleYesNINDS5027CofA PDFProtocol PDF
ND35666AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ASP91ALAMaleYesNINDS5023CofA PDFProtocol PDF
ND35668AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 GLU49LYSFemaleYesNINDS5625CofA PDFProtocol PDF
ND35669AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) FIG4 27C>TFemaleYesNINDS5644CofA PDFProtocol PDF
ND35670AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 VAL148GLYMaleYes CofA PDFProtocol PDF
ND35671AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ALA4VALFemaleYes CofA PDFProtocol PDF
ND35673ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ALA4VALFemaleAt RiskNINDS5624CofA PDFProtocol PDF
ND39030AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 ASP90ALAFemaleYesNINDS5020CofA PDFProtocol PDF
ND39032AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 LEU144PROMaleYes CofA PDFProtocol PDF
ND39034AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) FUS c.1566G>A (p.R522R)MaleYesNINDS5397CofA PDFProtocol PDF
ND39036ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) SOD1 GLY86ARGMaleAt Risk CofA PDFProtocol PDF
ND39037AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleYes CofA PDFProtocol PDF

Frontotemporal Degeneration

Catalog IDDiagnosisCell TypeCell SubtypeTransformantGene(s)Mutation(s)GenderAffectedFamily and Associated SpecimensCertificate of AnalysisProtocol
ND41867FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleYesNINDS5745CofA PDFProtocol PDF
ND41869FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleYesNINDS5745CofA PDFProtocol PDF
ND41870FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Retroviral) GRN SER116XAA
ND41870, ND41871 and ND41872
are sister clones***
MaleYesNINDS5881CofA PDFProtocol PDF
ND41871FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Retroviral) GRN SER116XAA
ND41870, ND41871 and ND41872
are sister clones***
MaleYesNINDS5881CofA PDFProtocol PDF
ND41872FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Retroviral) GRN SER116XAA
ND41870, ND41871 and ND41872
are sister clones***
MaleYesNINDS5881CofA PDFProtocol PDF
ND42765FRONTOTEMPORAL DEGENERATIONStem cellInduced pluripotent stem cellReprogrammed (Episomal)C9ORF72 (GGGGCC)n EXPANSIONFemaleYes CofA PDFProtocol PDF

Huntington's Disease

Catalog IDDiagnosisCell TypeCell SubtypeTransformantGene(s)Mutation(s)GenderAffectedFamily and Associated SpecimensCertificate of AnalysisProtocol
ND36997ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Lentiviral)HD CAG:33
Confirmed*
FemaleNo110CofA PDFProtocol PDF
ND36998HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Lentiviral)HD CAG:60FemaleYes110CofA PDFProtocol PDF
ND36999HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Lentiviral)HD CAG:180MaleYesNINDS4461CofA PDFProtocol PDF
ND38545HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:45FemaleYes690CofA PDFProtocol PDF
ND38546HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:45FemaleYes690CofA PDFProtocol PDF
ND38547HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:44MaleYes690CofA PDFProtocol PDF
ND38548HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:42
Confirmed*
FemaleYes690CofA PDFProtocol PDF
ND38549ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:29FemaleAt Risk690CofA PDFProtocol PDF
ND38551HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:50
iPSC DNA CAG:51**
MaleYes691CofA PDFProtocol PDF
ND38552HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:49FemaleYes691CofA PDFProtocol PDF
ND38554ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:17
Confirmed*
FemaleAt Risk691CofA PDFProtocol PDF
ND38555ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:17
Confirmed*
FemaleAt Risk691CofA PDFProtocol PDF
ND41113ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:33FemaleAt Risk110CofA PDFProtocol PDF
ND41114ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)SMN1 EX7-8DELFemaleNo553CofA PDFProtocol PDF
ND41654ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 18,17

ND41654,ND41655 and ND41658 are sister clones


MaleAt RiskNINDS3752CofA PDFProtocol PDF
ND41656HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 57
ND41656 and ND41657
are sister clones***
FemaleYesNINDS4250CofA PDFProtocol PDF
ND41657HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 57
ND41656 and ND41657
are sister clones***
FemaleYesNINDS4250CofA PDFProtocol PDF
ND41658ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD HD CAG:17
CAG:18
MaleAt RiskNINDS3752CofA PDFProtocol PDF
ND42222HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:109
ND42222, ND42223, and ND42224 are sister clones

FemaleYes CofA PDFProtocol PDF
ND42223HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:109
ND42222, ND42223, and ND42224 are sister clones

FemaleYes CofA PDFProtocol PDF
ND42224HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:109
ND42222, ND42223, and ND42224 are sister clones

FemaleYes CofA PDFProtocol PDF
ND42228HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 71
ND42228, ND42229 and ND42230
are sister clones***
FemaleYes CofA PDFProtocol PDF
ND42229HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 71
ND42228, ND42229 and ND42230
are sister clones***
FemaleYes CofA PDFProtocol PDF
ND42230HUNTINGTON DISEASE; HDStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG: 71
ND42228, ND42229 and ND42230
are sister clones***
FemaleYes CofA PDFProtocol PDF
ND42240ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)SMN1 EX7-8DEL
ND42240, ND41114 and ND42241
are sister clones


FemaleAt Risk553CofA PDFProtocol PDF
ND42241ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD SMN1 CAG: 26*EX7-8DEL
ND42240, ND41114 and ND42241
are sister clones***
FemaleAt Risk553CofA PDFProtocol PDF
ND42242ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:21FemaleNoNINDS3749CofA PDFProtocol PDF
ND42245ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:21
ND42244 and ND42245 are sister clones


MaleNo CofA PDFProtocol PDF
* Original HD CAG repeat length value reported by NINDS Repository submitter was verified using iPSC DNA.
** Original HD CAG repeat length value reported by NINDS Repository submitter differs from value obtained using iPSC DNA; both values are reported.

Parkinsonism

Catalog IDDiagnosisCell TypeCell SubtypeTransformantGene(s)Mutation(s)GenderAffectedFamily and Associated SpecimensCertificate of AnalysisProtocol
ND34391PARKINSON DISEASE,FAMILIAL, TYPE 1; PARK1Stem cellInduced pluripotent stem cellReprogrammed (Retroviral) SNCA TRIPLICATIONFemaleYesNINDS0020CofA PDFProtocol PDF
ND34393ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 ARG1441CYS
ND34393 and ND34394
are sister clones***
MaleAt RiskNINDS3316CofA PDFProtocol PDF
ND35367PARKINSON DISEASEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 GLY2019SERMaleYesNINDS3313CofA PDFProtocol PDF
ND35371ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 ARG1441CYSFemaleAt RiskNINDS3316CofA PDFProtocol PDF
ND38477PARKINSON DISEASEStem cellInduced pluripotent stem cellReprogrammed (Lentiviral)PARK2 PARK2 EX3-4DEL
1-BP DEL, 255A
MaleYesNINDS0729CofA PDFProtocol PDF
ND39896PARKINSON DISEASEStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleYes CofA PDFProtocol PDF
ND40018PARKINSON DISEASEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 GLY2019SER
Homozygous
FemaleYesNINDS5514CofA PDFProtocol PDF
ND40019ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 GLY2019SER
Heterozygous
ND40019 and ND40020
are sister clones***
MaleAt RiskNINDS5514CofA PDFProtocol PDF
ND40020ASYMPTOMATIC OR UNDIAGNOSED AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUALStem cellInduced pluripotent stem cellReprogrammed (Retroviral) LRRK2 GLY2019SER
Heterozygous
ND40019 and ND40020
are sister clones***
MaleAt RiskNINDS5514CofA PDFProtocol PDF

*** Other products including iPSC sub-clones derived from the same subject are available.
- iPSC line ND39896 was submitted to the NINDS Repository by the New York Stem Cell Foundation.

Controls

Catalog IDDiagnosisCell TypeCell SubtypeTransformantGene(s)Mutation(s)GenderAffectedFamily and Associated SpecimensCertificate of AnalysisProtocol
ND38549ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:29FemaleAt Risk690CofA PDFProtocol PDF
ND38554ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:17
Confirmed*
FemaleAt Risk691CofA PDFProtocol PDF
ND38555ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Retroviral) HD CAG:17
Confirmed*
FemaleAt Risk691CofA PDFProtocol PDF
ND41658ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD HD CAG:17
CAG:18
MaleAt RiskNINDS3752CofA PDFProtocol PDF
ND41864POPULATION/CONVENIENCE CONTROLStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleNoNINDS5744CofA PDFProtocol PDF
ND41865POPULATION/CONVENIENCE CONTROLStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleNoNINDS5744CofA PDFProtocol PDF
ND41866POPULATION/CONVENIENCE CONTROLStem cellInduced pluripotent stem cellReprogrammed (Retroviral)   MaleNoNINDS5744CofA PDFProtocol PDF
ND42242ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:21FemaleNoNINDS3749CofA PDFProtocol PDF
ND42245ASYMPTOMATIC; HD GENE-NEGATIVEStem cellInduced pluripotent stem cellReprogrammed (Episomal)HD CAG:21
ND42244 and ND42245 are sister clones


MaleNo CofA PDFProtocol PDF

All NINDS Repository iPSC orders must include a completed NINDS Repository iPSC Request Form and MTA prior to approval of the order. For detailed ordering information please see the NINDS Repository Instructions for Ordering Induced Pluripotent Stem Cells.Please submit all iPSC Request Forms to ninds@coriell.org.