Mexican Ancestry in Los Angeles, CA, USA [MXL]

The biomaterials currently available for this population are shown in the table below:

Population Mexican Ancestry in Los Angeles, CA, USA [MXL]
DNA Sample Panel HAPMAPV13
Individual DNA Samples 104
Individual Cell Cultures 104

Population Description

Principal Investigator for Community Engagement and Sample Collection:
Julio Licinio, University of California at Los Angeles, Los Angeles, CA

These cell lines and DNA samples were prepared from blood samples collected in Los Angeles, California. All of the samples are from parent-adult child trios. All parents in the trios identified themselves as having at least three out of four grandparents who were born in Mexico. Note that the individuals whose samples are included in this set are different from those who provided samples for the "Mexican-American" panels included in the NIGMS Human Genetic Cell Repository, even though both sets of samples were collected in Los Angeles.

It is important to include a reference to "Los Angeles, California" when describing the source of these samples. Including the name of the city and state where these samples were collected reinforces the point that the sample set, while not genetically "atypical", does not necessarily represent all people with Mexican ancestry in the United States, nor all Mexican people, whose population history is complex. The population should not be described as "Mexican American" out of respect for the expressed wishes of the donor community. The population also should not be described merely as "Hispanic" or "Latino", since those designations encompass many populations with many different geographic ancestries.

After the complete descriptor “Mexican Ancestry in Los Angeles, CA, USA” has been provided, it is acceptable to use the shorthand label “Mexican Ancestry” or the abbreviation “MXL” in the remainder of the article or presentation. However, the full descriptor for each population should be provided before the shorthand labels are used; this will help to avoid the risks associated with over-generalization of findings.

It may be scientifically appropriate to pool data from these samples with data from other ancestrally related groups, when the data show that the groups have similar allele frequencies. If the groups all have Mexican ancestry, the designation "Mexican ancestry" (abbreviation: MXA) to describe the combined analysis panel is recommended. If only groups very closely related to this group of Mexican ancestry individuals have similar allele frequencies, then another abbreviation may need to be used.

Additional guidance about how to refer to the populations can be found at Guidelines for Referring to the Populations in Publications and Presentations.

Policies and Guidelines