Induced Pluripotent Stem Cells
To facilitate research on differentiated cell types and other biomedical investigations, the NIGMS Repository offers several human induced pluripotent stem cell (hiPSC) lines derived from apparently healthy individuals or from individuals affected with heritable diseases. These hiPSCs were created using a variety of reprogramming techniques and submitted to the NIGMS Repository, where a distribution stock was made. In addition to several quality control tests (viability, lack of contamination, karyotyping, genome-wide microarray genotyping, and microsatellite matches with the parent cell culture), extensive pluripotency characterizations are performed on each NIGMS Repository hiPSC line. Pluripotency characterizations for each hiPSC line include three or more of the following assays:

  • Surface antigen expression
  • Embryoid body formation
  • PluriTest gene expression assay
A complete Certificate of Analysis (CofA) that includes images and quantitative test results is available for each hiPSC line. The CofA specifies which of the above pluripotency characterizations were performed on each hiPSC line.

Apparently Healthy hiPSC Lines
Records Return:  (16) Show

Catalog IDDescriptionParent LineTransformantGenderAgeRaceBiopsy SourceAffected StatusRelated SamplesCertificate of AnalysisProtocol
GM25256APPARENTLY HEALTHY CELL CULTURENot in RepositoryReprogrammed (Episomal)Male30 YRAsianSkinNo3181CofA PDFProtocol PDF
GM23392APPARENTLY HEALTHY FETAL TISSUEGM06114Reprogrammed (Retroviral) Male20 FWBlackLungNo910CofA PDFProtocol PDF
GM23396APPARENTLY HEALTHY FETAL TISSUEGM06111Reprogrammed (Retroviral) Female16 FWBlackSkinNo911CofA PDFProtocol PDF
GM23413APPARENTLY HEALTHY FETAL TISSUEGM06112Reprogrammed (Retroviral) Female16 FWBlackLungNo911CofA PDFProtocol PDF
GM23450APPARENTLY HEALTHY FETAL TISSUEGM06113Reprogrammed (Retroviral) Male20 FWBlackSkinNo910CofA PDFProtocol PDF
GM23716APPARENTLY HEALTHY FETAL TISSUEGM06111Reprogrammed (Episomal)Female16 FWBlackSkinNo911CofA PDFProtocol PDF
GM23476APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONSGM04506LentivirusFemale20 YRCaucasianSkinNo732CofA PDFProtocol PDF
GM23279APPARENTLY HEALTHY NON-FETAL TISSUENot in RepositoryReprogrammed (Retroviral) Female36 YRCaucasianSkinNo2997CofA PDFProtocol PDF
GM23280APPARENTLY HEALTHY NON-FETAL TISSUENot in RepositoryReprogrammed (Retroviral) Female36 YRCaucasianSkinNo2997CofA PDFProtocol PDF
GM23338APPARENTLY HEALTHY NON-FETAL TISSUEGM23248Reprogrammed (Retroviral) Male55 YRCaucasianSkinNo2980CofA PDFProtocol PDF
GM23340APPARENTLY HEALTHY NON-FETAL TISSUEGM23249Reprogrammed (Retroviral) Male44 YRCaucasianSkinNo2981CofA PDFProtocol PDF
GM23394APPARENTLY HEALTHY NON-FETAL TISSUEGM08333Reprogrammed (Retroviral) Male5 MOBlackForeskinNo3021CofA PDFProtocol PDF
GM23411APPARENTLY HEALTHY NON-FETAL TISSUEGM00041Reprogrammed (Retroviral) Female3 MOCaucasianSkinNo162CofA PDFProtocol PDF
GM23446APPARENTLY HEALTHY NON-FETAL TISSUEGM00038Reprogrammed (Retroviral) Female9 YRBlackSkinNo163CofA PDFProtocol PDF
GM23720APPARENTLY HEALTHY NON-FETAL TISSUEGM02254Reprogrammed (Episomal)Female22 YRCaucasianPeripheral veinNo3045CofA PDFProtocol PDF
GM24581APPARENTLY HEALTHY NON-FETAL TISSUEGM02036Reprogrammed (Episomal)Female11 YRCaucasianSkinNo203CofA PDFProtocol PDF


Disease-Specific hiPSC Lines
Records Return:  (24) Show

12
Catalog IDDiagnosisParent LineTransformantGenderAgeRaceBiopsy SourceAffected StatusGene(s)Mutation(s)Family and Associated SpecimensCertificate of AnalysisProtocol
GM24666ALZHEIMER DISEASE; ADexternalReprogrammed (Retroviral) Male83 YRCaucasianSkinYes  3234CofA PDFProtocol PDF
GM24675ALZHEIMER DISEASE; ADexternalReprogrammed (Retroviral) Female60 YR SkinYes  3236CofA PDFProtocol PDF
GM24683CYSTIC FIBROSIS; CFGM01014Reprogrammed (Episomal)Male13 YRCaucasian YesCFTR CFTRPHE508DEL
PHE508DEL
93CofA PDFProtocol PDF
GM23226DIABETES MELLITUS, JUVENILE-ONSET INSULIN-DEPENDENT; IDDMGM02416Reprogrammed (Retroviral) Female42 YRAmerican IndianSkinYes  383CofA PDFProtocol PDF
GM24559DYSTROPHIA MYOTONICA 1; DM1GM04602Reprogrammed (Episomal)Female2 YRCaucasianSkinYes  583CofA PDFProtocol PDF
GM23404FRIEDREICH ATAXIA 1; FRDAGM03816Reprogrammed (Retroviral) Female36 YRCaucasianSkinYesFXN FXN(GAA)n EXPANSION
(GAA)n EXPANSION
594CofA PDFProtocol PDF
GM23913FRIEDREICH ATAXIA 1; FRDAGM04078Reprogrammed (Retroviral) Male30 YRCaucasianSkinYesFXN FXN(GAA)n EXPANSION
(GAA)n EXPANSION
594CofA PDFProtocol PDF
GM23225HUNTINGTON DISEASE; HDGM04281Reprogrammed (Retroviral) Female20 YRCaucasianSkinYesHD(CAG)n EXPANSION
690CofA PDFProtocol PDF
GM25305LONG QT SYNDROME 2; LQT2ExternalReprogrammed (Retroviral) Female48 YRAsianSkinYesKCNH2ALA422THR
3183CofA PDFProtocol PDF
GM25267LONG QT SYNDROME 3; LQT3ExternalReprogrammed (Retroviral) Female18 YRCaucasianSkinYesSCN5AASN406LYS
3184CofA PDFProtocol PDF
GM23230MUSCULAR DYSTROPHY, BECKER TYPE; BMDGM04569Reprogrammed (Retroviral) Male38 YRCaucasianSkinYes  591CofA PDFProtocol PDF
GM23262MUSCULAR DYSTROPHY, BECKER TYPE; BMDGM04981Reprogrammed (Retroviral) Male6 YRCaucasianSkinYesDMDEX45-53DEL
2975CofA PDFProtocol PDF
GM23717MUSCULAR DYSTROPHY, CONGENITAL MEROSIN-DEFICIENT, 1A; MDC1AGM23311Reprogrammed (Episomal)Female3 YRCaucasianSkinYesLAMA2 LAMA22049_2050delAG
ARG2578TER
3006CofA PDFProtocol PDF
GM23298RETT SYNDROME; RTTGM11270Reprogrammed (Retroviral) Female8 YRCaucasianSkinYesMECP2ARG306CYS
3002CofA PDFProtocol PDF
GM23760SCHIZOPHRENIA; SCZDGM01792Reprogrammed (Lentiviral)Male26 YRCaucasianSkinYes  119CofA PDFProtocol PDF
GM23761SCHIZOPHRENIA; SCZDGM01835Reprogrammed (Lentiviral)Female27 YRCaucasianSkinYes  119CofA PDFProtocol PDF
GM23762SCHIZOPHRENIA; SCZDGM02497Reprogrammed (Lentiviral)Male23 YRCaucasianSkinYes  176CofA PDFProtocol PDF
GM23764SCHIZOPHRENIA; SCZDGM02503Reprogrammed (Lentiviral)Female27 YRCaucasianSkinYes  176CofA PDFProtocol PDF
GM23232SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-NEGATIVE, DUE TO ADENOSINE DEAMINASE DEFICIENCYGM01390Reprogrammed (Retroviral) Male3 MOCaucasianSkinYesADAGLY216ARG
2974CofA PDFProtocol PDF
GM23240SPINAL MUSCULAR ATROPHY I; SMA1GM03813Reprogrammed (Lentiviral)Male3 YRCaucasianSkinYesSMN1 SMN1EX7-8DEL
EX7-8DEL
553CofA PDFProtocol PDF