NIGMS

Human Genetic Cell Repository


The NIGMS Human Genetic Cell Repository, sponsored by the National Institute of General Medical Sciences, provides scientists around the world with resources for cell and genetic research. Established in 1972 at the Coriell Institute for Medical Research, the NIGMS Repository contains more than 11,700 cell lines, primarily fibroblasts and transformed lymphoblasts, and more than 5,900 DNA samples. Currently, the NIGMS HGCR catalog also contains over 80 iPSC lines.

Repository samples represent a variety of disease states, chromosomal abnormalities, apparently healthy individuals, and many distinct human populations. These samples comprise over 1,000 different OMIM diagnoses, and have been referenced in over 6,700 scientific publications.

Data on this website and information derived from the samples in the NIGMS Repository may not be used to determine the identity of any individual who provided a sample. Sample data available in the NIGMS Repository regarding race, ethnicity, and/or ancestry is self-reported information provided by sample submitters. Please direct any questions about these policies to NIGMS@coriell.org.

NIGMS News

  • Oct 2021

    High Molecular Weight DNA Now Available from NIGMS and NHGRI Collections

    The NIGMS Human Genetic Cell Repository (HGCR) and NHGRI Sample Repository for Human Genetic Research (SRHGR) now offer high molecular weight (HMW) DNA samples isolated from cell lines in the collections. HMW DNA is useful for long-read next-generation sequencing and studies that investigate large-scale genomic variation such as structural variation.

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  • Sep 2021

    Coriell Scientists Develop Novel Assay for Sample Authentication

    Biomedical research requires the use of primary samples that are derived directly from individuals affected by disease. The use of these primary research materials means that the health information connected to a person who donates a sample is tied up with the description of the sample itself. It’s critical, therefore, for biobanks to decouple this useful research material from a donor’s private information, a process known as de-identification. This protection of sample donors’ personal and identifiable information is paramount to preserving donor anonymity.

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  • Aug 2021

    Free Cell Line and DNA Samples in Exchange for Molecular Characterization

    The NIGMS Human Genetic Cell Repository is proud to launch a collaborative initiative with the scientific research community in an effort to enhance the molecular and biochemical characterizations of catalog-available samples.

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