Sample Processing and QC

The Coriell Institute applies validated and reproducible workflows to all sample processing activities, including extraction of nucleic acids, cell culturing, and protein purification. Every stage is subjected to rigorous quality control (QC) to ensure the highest standards of biospecimen integrity.

QC procedures include:

• DNA/RNA purity and integrity testing
• Mycoplasma detection for cell lines
• STR profiling for cell line authentication
• Protein quantification and contamination screening

These measures ensure sample readiness for applications such as RNA-seq, whole-genome sequencing (WGS), and mass spectrometry.

With decades of lab experience and thousands of processed samples, Coriell supports clinical trials requiring high reproducibility, sample standardization, and regulatory-quality documentation. Our rigorous quality control pipeline delivers reliable, research-grade specimens optimized for downstream analysis.

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