iPSCs are created by introducing specific transcription factors, commonly known as the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc), into differentiated somatic cells. This process resets the cells’ identity, reverting them to an embryonic-like pluripotent state. At Coriell, we offer a range of reprogramming services tailored to research and clinical applications:
Viral Delivery: Efficient methods using retroviruses and lentiviruses.
Non-Integrative Methods: Safe approaches such as episomal plasmids and Sendai viruses.
Coriell’s scientists continually optimize these techniques to achieve high-efficiency reprogramming while ensuring the genetic and epigenetic stability of derived iPSCs.
