The National Institute of Neurological Disorders and Stroke is committed to gene discovery, as a strategy for identifying the genetic causes and correlates of nervous system disorders. The NINDS Human Genetics Resource Center banks samples donated by individuals with cerebrovascular disease, dystonia, epilepsy, motor neuron disease, Parkinsonism and Tourette Syndrome, as well as population controls.
| Cerebrovascular Disease | DNA | LCL |
| Dystonia | DNA | LCL |
| Epilepsy | DNA | LCL |
| Motor Neuron Disease | DNA | LCL |
| Parkinsonism | DNA | LCL |
| Tourette Syndrome | DNA | LCL |
| Controls | DNA | LCL |
New Cerebrovascular Disease Samples Available!
More than 1000 DNA samples from the REasons for Geographic and Racial Differences in Stroke (REGARDS) project have been added to the NINDS Human Genetics Resource Center and are available through the catalog to the scientific community. Since 2003, REGARDS, a NINDS funded project, has worked to better understand geographic and ethnic contributions to risk of stroke.
NINDS Lymphoblastoid Cell Lines (LCLs) were used in this study to explore the role of Parkinson’s disease-associated LRRK2 protein and its kinase activity in regulating reactive oxygen species production and oxidative damage.
read moreThis study used Parkinson’s disease patient cells with LRRK2 mutations to investigate the relationship between LRRK2 kinase activity, mtDNA damage and mitophagy.
read moreThis article describes a PCR-based assay (Mito DNADX) that quantifies mtDNA damage in a scalable platform.
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