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The third leading cause of death in the United States, Stroke is an acute neurological event leading to death of neural tissues. Although the majority of strokes are ischemic strokes, meaning there is oxygen deprivation to the brain, almost 20% of strokes are hemorrhagic, resulting from bleeding into the brain. Stroke is a complex disorder and likely multigenic in nature, resulting from a combination of genetic and environmental factors. These well characterized risk factors that contribute to the incidence of stroke include hypertension, cardiac disease, sickle cell disease, hyperhomocysteinemia, family history of stroke and smoking. The NINDS Cell and DNA repository includes subjects with different types of stroke including ischemic, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, unruptured intracranial aneuryism, silent cerebral infarction, and vascular cognitive impairment. Also included in the collection are affected blood relatives and unaffected blooded relatives of those proband subjects, spouses (spousal controls), and normal healthy individuals (including population and convenience controls). |
