1. Tchounwou PB, ..., Chen X, ... Research Infrastructure Core Facilities at Research Centers in Minority Institutions: Part I—Research Resources Management, Operation, and Best Practices. Int J Environ Res Public Health 2022; 19: 16979.

  2. Xiong Z, Chen X. NRF2 Controls the Competitive Fitness of Squamous Epithelial Cells in the Mouse Esophagus. Cell Mol Gastroenterol Hepatol. 2022 Nov 6:S2352-345X(22)00221-1.

  3. Yang, W., Liu, H., Zhang, R... Chen X, Patieno SR, Wei Q. Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk. npj Precis. Onc. 6, 48 (2022).

  4. Li Y, Cheng Q, Xiong Z, Paiboonrungruang C, Adekoya T, Li Y, Chen X. Lymphatic Drainage System and Lymphatic Metastasis of Cancer Cells in the Mouse Esophagus. Dig Dis Sci. 2022 Jun 21. doi: 10.1007/s10620-022-07586-6. Epub ahead of print. PMID: 35727424.

  5. Chen X, Li Y, Paiboonrungruang C, Li Y, Peters H, Kist R, Xiong Z. PAX9 in cancer development. Int J Mol Sci 2022;23:5589.

  6. Shi N, Chen X, Chen T. Anthocyanins in Colorectal Cancer Prevention Review. Antioxidants 2021, 10, 1600.

  7. Paiboonrungruang C, Simpson E, Xiong Z, Huang C, Li J, Li Y, Chen X. Development of targeted therapy of NRF2high esophageal squamous cell carcinoma. Cell Signal. 2021;86:110105.

  8. Shi M, Ren S, Chen H, Li J, Huang C, Li Y, Han Y, Li Y, Sun Z, Chen X, Xiong Z. Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells. J Pathol. 2021;253(4):384-395.

  9. Fang Y, Li W, Chen X. P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium. Dig Dis Sci. 2021;66(12):4263-4273.

  10. Yang CS, Chen XL. Research on esophageal cancer: with personal perspectives from studies in China and Kenya. Int J Cancer. 2021;149(2):264-276.

  11. Niture S, Lin M, Odera JO, Moore J, Zhe H, Chen X, Suy S, Collins SP, Kumar D. TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation. Int J Biochem Cell Biol. 2021 Jan;130:105885.

  12. Li Y, Li Y, Chen X. Notch and esophageal squamous cell carcinoma. Adv Exp Med Biol 2021;1287:59-68.

  13. Odera JO, Xiong Z, Huang C, Gu N, Yang W, Githang'a J, Odera E, Paiboonrungruang C and Chen X. NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma. Biochem J. 2020;477(16):3075-3089.

  14. Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Muvlaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen X, Randell SH, Weissman BE, Major MB. A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. J Pathol. 2020;252(2):125-137.

  15. Adekoya TO, Smith N, Aladeniyi T, Blumer JB, Chen XL, Richardson RM. Activator of G protein signaling 3 modulates prostate tumor development and progression. Carcinogenesis. 2019; 40(12):1504-1513 .

  16. Yang W, Liu H, Duan B, Xu X, Carmody D, Luo S, Walsh KM, Abbruzzese JL, Zhang X, Chen X, Wei Q. Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk. Cancer Sci. 2019;110(6):2022-2032.

  17. Fu J, Xiong Z, Huang C, Li J, Yang W, Han Y, Paiboonrungruan C, Major MB, Chen K, Kang X, Chen XL. Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus. J Biol Chem. 2019;294(1):327-340.

  18. Ma S, Paiboonrungruan C, Yan T, Williams KP, Major MB, Chen X. Targeted therapy of esophageal squamous cell carcinoma: Nrf2 signaling pathway as a target. Ann NY Acad Sci (invited review). 2018 Dec;1434(1):164-172.

  19. Ma S, Yan T, Liu D, Wang K, Wang J, Song J, Wang T, He W, Bai J, Jin L, Chen X. Neoadjuvant chemotherapy followed by minimally invasive esophagectomy is safe and feasible for treatment of esophageal squamous cell carcinoma. Thorac Cancer. 2018 Feb;9(2):310-315.

  20. Xiong Z, Ren S, Chen H, Liu Y, Huang C, Zhang Y, Odera J, Chen T, Kist R, Peters H, Garman K, Sun Z and Chen X. Pax9 regulates squamous cell differentiation and carcinogenesis in the oro-esophageal epithelium. J Pathol 2018;244:164-175.

  21. Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee D-K, Zhang L, Lee Y-C, Yuan J, Abrams JA, Wang Tc, Sepulveda AR, Wu Q, Chen H, Sun X, She J, Chen X, Que J. Transitional basal cells at the squamous-columnar junction generate Barrett’s oesophagus. Nature 2017;550:529-533.

  22. Fan H, Paiboonrungruan C, Zhang X, Prigge JR, Schmidt EE, Sun Z, Chen X. Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells. Biochem Biophys Res Comm 2017;493:833-839.

  23. Cuevas-Nunez MC, Gomes CBF, Woo SB, Ramsey MR, Chen XL, Xu S, Xu T, Zhan Q, Murphy GF, Lian CG. Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jun 16. pii: S2212-4403(17)30845-3.

  24. Odera J, Odera E, Githang’a J, Walong E, Li F, Xiong Z, Chen X. Esophageal Cancer in Kenya. Am J Dig Dis 2017;4(3):23-33

  25. Liu Y, Li Y, Fu Y, Liu T, Liu X, Zhang X, Fu J, Guan X, Chen T, Chen X, Sun Z. Quantitative Prediction of Oral Cancer Risk in Patients with Oral Leukoplakia Based on Exfoliative Cytology. OncoTarget 2017;8:46057-46064.

  26. Xiong Z, He J, Chen X. New strategies in esophageal carcinoma: promises and problems (invited commentary). J Thoracic Dis 2016; 8(11):E1501-E1504.

  27. Lan A, Li W, Liu Y, Xiong Z, Zhang X, Zhou S, Palko O, Chen H, Kapita M, Prigge JR, Schmidt EE, Chen X, Sun Z, Chen X. Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety. Oncotarget 2016;7(33):53502-53514.

  28. Liu Y, Xiong Z, Beasley A, D'Amico T, Chen X. Personalized target therapy for esophageal squamous cell carcinoma: an update. Ann NY Acad Sci 2016;1381:66-71.

  29. Li J, Chen X, Shaker A, Oshima T, Shan J, Miwa H, Feng C, Zhang J. Contribution of immunomodulators to gastroesophageal reflux disease and its complications. Ann NY Acad Sci 2016;1380:183-194.

  30. Zhu Y, Wang P, Zhao Y, Yang C, Clark A, Leung T, Chen X, Sang S. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Mar 25. pii: S0891-5849(16)30005-3.

  31. Yang CS, Chen X and Tu S. Etiology and prevention of esophageal cancer. GI Tumors 2016;3(1):3-16.

  32. Chen H, Beasley A, Hu Y and Chen X. A zebrafish model for studies on esophageal epithelial biology. PLoS One 2015;10(12):e0143878.

  33. Zhu Y, Fu J, Shurlknight KL, Soroka DN, Hu Y, Chen X, Sang S. Novel Resveratrol-based aspirin prodrugs: synthesis, metabolism, and anticancer activity. J Med Chem. 2015;58(16):6494-506.

  34. Kang X, Chen K, Li Y, Li J, D'Amico T and Chen X. Personalized target therapy for esophageal squamous cell carcinoma. World J Gastroenterol 2015;21(25):7648-58.

  35. Liu Y, Chen H, Sun Z and Chen X. Molecular Mechanisms of Ethanol-associated Oro-esophageal Squamous Cell Carcinoma. Cancer Letters 2015; 361(2):164-73.

  36. Liu Y, Li J, Liu X, Liu X, Khawar W, Zhang X, Wang F, Chen X, Sun Z. Quantitative risk stratification of oral leukoplakia with exfoliative cytology. PLoS ONE 2015; 10(5):e0126760.

  37. He J, Fang Y and Chen X. Surgical models of gastroesophageal reflux in mice. JoVE 2015 (102):e53012.

  38. Chen H, Fu J, Chen H, Hu Y, Soroka D, Prigge J, Schmidt E, Yan F, Major MB, Chen X, Sang S (2014) Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem Res Toxicol 27(9):1575-85.

  39. Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X. Translational research on Barrett's esophagus. Ann N Y Acad Sci. 2014;1325:170-86.

  40. Dellon ES, Speck O, Woodward K, Covey S, Rusin S, Gebhart JH, Chen X, Woosley JT, Shaheen NJ (2014). Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump-inhibitor responsive esophageal eosinophilia: A prospective study. Clin Gastroenterol Hepatol. 12(12):2015-22.

  41. Chen H, Fang Y, Li W, Orlando R, Shaheen NJ and Chen X (2013). NFkB and Nrf2 in esophageal epithelial barrier function (Invited Commentary Review). Tissue Barriers 2: e27463.

  42. Ren D, Zheng G, Bream S, Tevebaugh W, Shaheen NJ and Chen X (2014). Cdx1 and Cdx2 single nucleotide polymorphism are associated with Barrett’s esophagus. Dig Dis Sci 59:57-63.

  43. Chen H, Hu Y, Fang Y, Tevebaugh W, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X (2014). Nrf2 deficiency impairs the barrier function of mouse esophageal epithelium. Gut. 63(5):711-9.

  44. Fang Y, Chen X, Bajpai M, Verma A, Das KM, Souza RF, Garman KS, Donohoe CL, O'Farrell NJ, Reynolds JV, Dvorak K. Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Ann N Y Acad Sci. 2013;1300:187-99.

  45. Bellizzi AM, Nardone G, Compare D, Bor S, Capanoglu D, Farré R, Neumann H, Neurath MF, Vieth M, Chen H, Chen X. Tissue resistance in the normal and diseased esophagus. Ann N Y Acad Sci. 2013;1300:200-12.

  46. Fang Y, Chen H, Hu Y, Djukic Z, Tevebaugh W, Shaheen NJ, Orlando RC, Hu J, Chen X (2013). Gastroesophageal reflux activates the NFkB pathway and impairs esophageal barrier function in mice. AJP GI & Liver 305(1):G58-65.

  47. Chen H, Soroka DN, Zhu Y, Hu Y, Chen XL, Sang S (2013). Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice. Chem Res Toxicol. 26(6):976-85.

  48. Raghuwanshi SK, Smith N, Rivers EJ, Thomas AJ, Sutton N, Hu Y, Mukhopadhyay S, Chen XL, Leung T, Richardson RM (2013). G Protein-Coupled Receptor Kinase 6 Deficiency Promotes Angiogenesis, Tumor Progression, and Metastasis. J Immunol. 190(10):5329-36.

  49. Chen H, Soroka DN, Hu Y, Chen X, Sang S (2013). Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. Mol Nutr Food Res. 57(3):447-58.

  50. Hu B, Chen H, Liu X, Zhang C, Cole GJ, Lee J, Chen X (2013) Transgenic overexpression of zCdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish 10: 218-227.

  51. Liu K, Lu Y, Chen H, Wu S, Ku W, Nakagawa H, Kita Y, Natsugoe S, Sun J, Peters J, Rustgi A, Onaitis M, Chen X, Que J (2013). Sox2 Cooperates with Inflammation-mediated Stat3 Activation in the Malignant Transformation of Basal Progenitor Cells in the Foregut. Cell Stem Cell 2013;12:304-15.

  52. Orman ES, Kim HP, Bulsiewicz WJ, Cotton CC, Dellon ES, Spacek MB, Chen X, Madanick RD, Pasricha S, Shaheen NJ (2013). Intestinal Metaplasia Recurs Infrequently in Patients Successfully Treated for Barrett's Esophagus With Radiofrequency Ablation. Am J Gastroenterol. 108:187-95.

  53. Bulsiewicz WJ, Kim HP, Dellon ES, Cotton CC, Pasricha S, Madanick RD, Spacek MB, Bream SE, Chen X, Orlando RC, Shaheen NJ (2013). Safety and Efficacy of Endoscopic Mucosal Therapy With Radiofrequency Ablation for Patients With Neoplastic Barrett's Esophagus. Clin Gastroenterol Hepatol. 2013;11(6):636-42.

  54. Chen X, Zhang X, Lu Y, Shim J-Y, Sang S, Sun Z, Chen X (2012). Chemoprevention of DMBA-induced hamster cheek pouch carcinogenesis by topical application of a 5-lipoxygenase inhibitor, garcinol. Nutrition & Cancer 42:1811-18.

  55. Kim HP, Bulsiewicz WJ, Cotton CC, Dellon ES, Spacek MB, Chen X, Madanick RD, Pasricha S, Shaheen NJ (2012). Focal endoscopic mucosal resection before radiofrequency ablation is equally effective and safe compared with radiofrequency ablation alone for the eradication of Barrett's esophagus with advanced neoplasia. Gastrointest Endosc. 76:733-9.

  56. Dellon ES, Chen X, Miller CR, Woosley JT, Shaheen NJ (2012). Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis. Am J Gastroenterol. 107(10):1503-11.

  57. Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X (2012) Transcript Profiling Identifies Dynamic Gene Expression Patterns and an Important Role for Nrf2/Keap1 Pathway in the Developing Mouse Esophagus. PLoS ONE 7(5): e36504

  58. Yang L, Wang LS, Chen XL, Gatalica Z, Qiu S, Liu Z, Stoner G, Zhang H, Weiss H, Xie J (2012). Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. Int J Biochem Mol Biol. 3: 46-57.

  59. Dellon ES, Bower JJ, Keku TO, Chen X, Miller CR, Woosley JT, Orlando RC, Shaheen NJ (2012). Markers of tyrosine kinase activity in eosinophilic esophagitis: A study of the FIP1L1-PDGFRα fusion gene, pERK 1/2, and pSTAT5. Dis Esoph 25(2):166-74.

  60. Chen H, Lv L, Soroka D, Warin RF, Parks TA, Hu Y, Zhu Y, Chen X, and Sang S (2012). Metabolism of [6]-Shogaol in Mice and in Cancer Cells. Drug Metab Dispos. 40(4):742-53.

  61. Yang H, Jia X, Chen X, Yang CS, and Li N (2012). Time selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: The possible role of nuclear factor kappaB signaling pathway. Int J Cancer 131(7):1517-27.

  62. Roesly HB, Khan MR, Chen H, Hill KA, Narendran N, Watts GS, Chen X, and Dvorak K (2012). The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: The role of deoxycholic acid. AJP GI & Liver 302:G864-72.

  63. Garman KS, Orlando RS and Chen X (2012). Experimental Models for Barrett's Esophagus and Esophageal Adenocarcinoma. AJP GI & Liver 302(11):G1231-4.

  64. Guan XB, Sun Z, Chen X, Wu HR, Zhang XY. Inhibitory effects of Zengshengping fractions on DMBA-induced buccal pouch carcinogenesis in hamsters. Chin Med J (Engl). 2012 Jan;125(2):332-7.

  65. Fang DC, Lin SR, Huang Q, Yu ZL, Yuan YZ, Chen MH, Bai WY, Chen X, Zhang J, Li YQ, Zhou LY, Ke MY, Fang XC, Lan Y. Chinese National Consensus on diagnosis and management of Barrett's esophagus (BE): revised edition, June 2011, Chongqing, China. J Dig Dis. 2011;12(6):415-9.

  66. Chen X, Li Z, Sun X, Ma H, Chen X, Ren J, Hu K (2011). New Method for the Synthesis of Sulforaphane and Related Isothiocyanates. Synthesis 2011;24:3991–3996.

  67. Guo Y, Wang X, Zhang X, Sun Z and Chen X (2011). Ethanol Promotes Chemically Induced Oral Cancer in Mice through Activation of the 5-Lipoxygenase Pathway of Arachidonic Acid Metabolism. Cancer Prev Res 4:1863-72.

  68. Chen H, Parks TA, Chen X, Gillitt ND, Jobin C and Sang S (2011). Structural identification of mouse fecal metabolites of theaflavin 3,3’-digallate using liquid chromatography tandem mass spectrometry. J Chromtography A 1218:7297-306.

  69. Yang H, Fang J, Jia X, Han C, Chen X, Yang CS, Li N (2011). Chemopreventive effects of early-stage and late-stage supplementation of vitamin E and selenium on esophageal carcinogenesis in rats maintained on a low vitamin E/selenium diet. Carcinogenesis 32: 381-388.

  70. Dellon ES, Chen X, Miller CR, Fritchie KF, Rubinas TC, Woosley JT, Shaheen NJ (2011). Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease. Am J Gastroenterol 106:264-71.

  71. Chen H, Fang Y, Tevebaugh W, Orlando RC, Shaheen NJ, Chen X (2011). Molecular mechanisms of Barrett’s esophagus. Dig Dis Sci 56: 3405-20.

  72. Dvorak K, Goldman A, Kong J, Lynch JP, Hutchinson L, Houghton JM, Chen H, Chen X, Krishnadath KK, Westra WM. Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Ann N Y Acad Sci. 2011; 1232:381-91.

  73. Rishniw M, Rodriguez P, Que J, Burke ZD, Tosh D, Chen H, Chen X. Molecular aspects of esophageal development. Ann N Y Acad Sci. 2011;1232:309-15.

  74. Shao X, Chen X, Badmaev V, Ho C-T, Sang S (2010) Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry. Rapid Comm Mass Spec 24:1770-8.

  75. McCalla-Martin AC, Chen X, Linder KE, Estrada JL and Piedrahita JA (2010) Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human sonic hedgehog transcriptional activator, K5-hGli2∆N. Transgenic Res 19: 869-87.

  76. Hu B, Zhang C, Baawo K, Cole G, Lee J, Chen X (2010) Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research. Oral Oncol 46:31-7

  77. Sun Z, Guan X, Li N, Liu X, Chen X (2010). Chemoprevention of oral cancer in animal models and human patients with ZengShengPing, a mixture of medicinal herbs. Oral Oncol 46:105-110.

  78. Graf RN, Robles FE, Chen X, Wax A. (2009) Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations. J Biomed Opt. 14:064030.

  79. Hao J, Zhang B, Liu B, Lee M, Hao X, Reuhl KR, Chen X, Yang CS (2009). Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model. Int J Cancer 124:1270-5.

  80. Hao J, Zhang B, Liu B, Yang CS and Chen X (2009). Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. BMC Gastroenterology 9:59-65.

  81. Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, and Chen X (2009). Differential gene expression in normal esophagus and Barrett’s esophagus. J Gastroenterology 44;897-911.

  82. Yang P, Sun Z, Chan D, Cartwright C, Li N, Chen X, Newman RA (2008). Zyflamend® reduces LTB4 formation and prevent oral carcinogenesis, in a 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis 29(11):2182-9.

  83. Raghuwanshi SK, Nasser MW, Chen X, Strieter RM, and Richardson RM (2008). Depletion of βarrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 180:5699-5706.

  84. Chen X, Qin R, Liu B, Ma Y, Su Y, Yang CS, Glickman J, Odze R, Shaheen NJ (2008). Multilayered epithelium in a rat model and human Barrett's esophagus: Expression patterns of transcription factors and differentiation markers. BMC Gastroenterol 8:1.

  85. Sun Z, Sood S, Li N, Yang P, Newman RA, Yang CS and Chen X (2008) Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases. Oral Oncology 44:652-657.

  86. Liu T, Zhang X, So C-K, Wang S, Chen Z-Y, Patterson AP, Yang CS and Chen X (2007) Regulation of Cdx2 expression in human esophageal epithelial cells and its contribution to intestinal metaplasia of the esophagus. Carcinogenesis 28:488-96.

  87. Zhang X, Yang F, Shim J-Y, Kirk KL, Anderson DE and Chen X (2007) Identification of arsenic-binding proteins in human breast cancer cells. Cancer Letters 255:95-106.

  88. Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X (2006) Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors. Carcinogenesis 27:2702-2708.

  89. Yang P, Chan D, Felix E, Madden T, Klein RD, Shureiqi I, Chen X, Dannenberg AJ, and Newman RA (2006). Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids. Prostaglandins, Leukotrienes and Essential Fatty Acids 75:385-95.

  90. Zhang X, Feng J, Ye X, Yao Y, Zhou P and Chen X. (2006) Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer. Gynecologic Oncology 103:848-852.

  91. Chen X, Sood S, Yang CS, Li N and Sun Z (2006). Five-lipoxygenase pathway of arachidonic acid metabolism in carcinogenesis and cancer chemoprevention. Current Cancer Drug Target 6: 519-532.

  92. Zhao H, Qin R, Chen X, Sheng X, Wu J, Wang D and Chen G. (2006) Microvessel density is a prognostic marker of human gastric cancer. World J Gastroenterol 12: 7598-7603.

  93. Sood S, Shiff SA, Yang CS and Chen X. Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention. Oral Oncology 2005; 41: 562-567.

  94. Li, N., Sood, S., Wang, S., Fang, M., Wang, P., Sun, Z., Yang, C.S. and Chen, X. Overexpression of cyclooxygenase 2 and 5-lipoxygenase in hamster and human oral cancer and chemopreventive effects of Celecoxib and Zileuton. Clin. Cancer Res., 2005;11: 2089-2096.

  95. Chen, X., Wang, S., Wu, N., Sood, S., Wang, P., Jin, Z., Beer, D.G., Giordano, T.J., Lubet, R.A. and Yang, C.S. Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma, and inhibitory effects of Zileuton and Celecoxib on carcinogenesis. Clin. Cancer Res. 2004; 10:6703-6709.

  96. Hong, J., Bose, M., Ju, J., Ryu, J., Chen, X., Sang, S., Lee, M. and Yang, C.S. Modulation of arachidonic acid metabolism by curcumin and related b-diketone derivatives: Effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase. Carcinogenesis 2004; 25: 1671-1679.

  97. Su Y*, Chen X*, Klein M, Fang M, Wang S, Yang CS and Goyal RK. Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett’s esophagus. Lab. Invest. 2004; 84: 753-765. (*equal contribution to this work)

  98. Chen X, Wang S, Wu N, and Yang CS. Leukotriene A4 hydrolase as a target for cancer therapy and prevention. Current Cancer Drug Targets 2004; 4: 267-283.

  99. Chen X, Li N, Wang S, Wu N, Hong J, Jiao X, Krasna MJ and Yang CS. Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin. J. Natl. Cancer Inst. 2003; 95:1053-1061.

  100. Chen X, Li N, Wang S, Hong J, Fang M, Yousselfson J, Yang P, Newman RA, Lubet RA and Yang CS. Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis 2002; 23:2095-2102.

  101. Chen X, Ding YW, Liu CG, Yang GY and Yang CS. Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and human patients. Carcinogenesis 2002; 23:123-131.

  102. Li N, Chen X, Liao J, Yang G, Wang S, Josephson Y, Han C, Chen J, Huang M-T and Yang CS. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis, 2002; 23:1307-1313.

  103. Chen X and Yang CS. Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis. Carcinogenesis 2001, 22:1119-1129.

  104. Chen X, Mikhail S, Ding W, Yang G-Y, Bondoc F and Yang CS. Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Carcinogenesis 2000; 21:1531-1536.

  105. Chen X, Ding W, Yang G-Y, Goldstein SR, Curtis SK and Yang CS. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis 2000; 21:257-263.

  106. Chen X, Yang G-Y, Ding W, Bondoc F, Curtis SK and Yang CS. An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis 1999; 20:1801-1807.

  107. Chen X and Yang CS. Iron and esophageal cancer. Cancer Res. Alert 1999; I(3):33-35.

  108. Goldstein SR, Yang G-Y, Chen X, Curtis SK and Yang CS. Evidence for a role of nitric oxide in the development of Barrett’s esophagus and esophageal adenocarcinoma in a rat model. Carcinogenesis 1998;19:1445-1449.

  109. Yang G-Y, Wang Z-Y, Kim S, Liao J, Chen X, Smith TJ and Yang CS. Characterization of early pulmonary hyperproliferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model with A/J mice. Cancer Res. 1997;57:1889-1894.

Clinical Orthopedics

  1. Yuan Y, Lu H, Kou B, Chen X and Lin J. Midterm followup study of Meuli total wrist replacement. Chin. J. Orthop. 1996;16:285-288.

  2. Lin J, Lu H and Chen X. Change of bone mass around femoral stem after prosthetic hip arthroplasty. Chin. J. Orthop. 1995;15(8):494-496.

  3. Lu H, Chen X, Lin J, Yuan Y and Gao T. Preliminary experience on selection of sequence of operations for rheumatoid arthritis patients with polyarticular deformities of the lower extremities. Chin. J. Orthop. 1995;15:483-486.

  4. Chen X, Zhao Z and Lu H. A large-scale epidemiological study on hallux valgus angle of general Chinese population. Chin. J. Orthop. 1995;14:576-578.

  5. Lu H, Kou B, Yuan Y, Lin J and Chen X. Follow-up result of fourteen cases of the first metatarsophalangeal joint arthroplasty with titanium total joint prostheses. Chin. J. Surg. 1994:32:542-544.

  6. Chen X, Lin J, Zhang X, Chen F and Lu H. Postoperative rehabilitation for total knee patients. Chin. J. Rehab. Med. 1994;9:49-51.

  7. Chen X, Lu H and Lin J. Observation of PMMA bone cement with scanning electroscope: the efficacy of vacuum-mixing. J. Bone Joint Surg. (Br) 1993;75B:224.

  8. Lin J, Lu H and Chen X. Previously deposited autologous blood transfusion for surgically treated rheumatoid patients. Chin. J. Surg. 1993;31:592-594.

  9. Lu H, Gao T and Chen X. Prosthetic arthroplasty and other surgical procedures for psoriatic arthritis patients with severe deformities. Chin. J. Surg. 1993;31:674-676.

  10. Lu H, Yuan Y, Gao T, Kou B, Lin J and Chen X. Preliminary experience of the first consecutive 100 total knee arthroplasty for late-stage rheumatoid

Invited Book Chapters

  1. Chen X. a. Are genetic changes alone, without reflux, able to produce esophageal adenocarcinoma? (page 494-498) b. Studies with the esophagogastroduodenal anastomosis model of esophageal adenocarcinoma: Oxidative stress & aberrant arachidonic acid metabolism (page 478-485) c. Barrett’s esophagus: Is there a clinically useful animal model at all? (page 436-443) d. What are the compared deleterious effects of bile acids and trypsin concentration in the refluxate of animal models? (page 427-431) In: Giuli R, Scarpignato C, Collard J-M, Richter JE (eds) The Duodeno-gastro-esophageal Reflux. John Libbey Eurotext, Paris, 2006.

  2. Chen X and Yang CS. Barrett’s esophagus – Preclinical models for investigation. In: Jobe BA, Thomas CR, Hunter JG, Tran N (eds) Esophageal Tumors: Principles and Practice. Demos Medical Publishing, New York, 2009.

  3. Chen X. Combination of Aspirin and Omega-3 Polyunsaturated Fatty Acid for Cancer Chemoprevention. In: Pereira LS (ed) Cancer Research Perspectives. Nova Publishers Inc, New York, 2008.

  4. Yang CS, Chen X, Yang GY. Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention. In: Kong A-N (ed). Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention. CRC Press 2013, Page 41-54.