All Publications

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
Le BV., Podszywalow-Bartnicka P., Maifrede S. , Sullivan-Reed K., Nieborowaska-Skorska M., Golovine K., Yao JC., Nejati R., Cai KQ., Caruso LB., Swatler J., Dabrowski M., Lian Z., Valent P., Paietta EM., Levine RL., Fernandez HF., Tallman MS., Litzow MR., Huang J., Challen GA., Link D., Tempera I., Wasik MA., Piwocka K., Skorski T. (2020) Cell reports. 2020. Oct 6;33(1):108221.

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ. Cell. 2018 Nov 15;175(5):1244-1258.e26. doi: 10.1016/j.cell.2018.09.051. Epub 2018 Oct 25. PubMed PMID: 30454645; PubMed Central PMCID: PMC6247954.

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
Maifrede S, Nieborowska-Skorska M, Sullivan-Reed K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Toma M, Chatain N, Rydzanicz M, Zhao H, Jelinek J, Piwocka K, Sliwinski T, Stoklosa T, Ploski R, Fischer T, Sykes SM, Koschmieder S, Bullinger L, Valent P, Wasik MA, Huang J, Skorski T. Blood. 2018 Jul 5;132(1):67-77. doi: 10.1182/blood-2018-02-834895. Epub 2018 May 21. PubMed PMID: 29784639; PubMed Central PMCID: PMC6034642.

Tracking hematopoietic precursor division ex vivo in real time
Wang Y, Tian H, Cai W, Lian Z, Bhavanasi D, Wu C, Sato T, Kurokawa M, Wu D, Fu L, Wang H, Shen H, Liang D, Huang J. Stem Cell Res Ther. 2018 Jan 23;9(1):16. doi: 10.1186/s13287-017-0767-z. PubMed PMID: 29361987; PubMed Central PMCID: PMC5781326.

Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells
Bhavanasi D, Wen KW, Liu X, Vergez F, Danet-Desnoyers G, Carroll M, Huang J, Klein PS. Blood Cancer J. 2017 Nov 30;7(12):636. doi: 10.1038/s41408-017-0003-1. PubMed PMID: 29187738; PubMed Central PMCID: PMC5802493.

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
Hou P, Wu C, Wang Y, Qi R, Bhavanasi D, Zuo Z, Dos Santos C, Chen S, Chen Y, Zheng H, Wang H, Perl A, Guo D, Huang J. Cancer Res. 2017 Aug 15;77(16):4402-4413. doi: 10.1158/0008-5472.CAN-16-1627. Epub 2017 Jun 16. PubMed PMID: 28625976; PubMed Central PMCID: PMC5559306.

Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors
Yu X, Wu C, Bhavanasi D, Wang H, Gregory BD, Huang J. Blood Adv. 2017 Jun 13;1(14):887-898. doi: 10.1182/bloodadvances.2016003384. eCollection 2017 Jun 13. PubMed PMID: 29296732; PubMed Central PMCID: PMC5737588.

Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice
Wang X, Li M, Gao Y, Gao J, Yang W, Liang H, Ji Q, Li Y, Liu H, Huang J, Cheng T, Yuan W. Exp Cell Res. 2016 Jun 10;344(2):219-28. doi: 10.1016/j.yexcr.2016.04.017. Epub 2016 May 7. PubMed PMID: 27163399.

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
Hou P, Chen S, Wang S, Yu X, Chen Y, Jiang M, Zhuang K, Ho W, Hou W, Huang J, Guo D. Sci Rep. 2015 Oct 20;5:15577. doi: 10.1038/srep15577. PubMed PMID: 26481100; PubMed Central PMCID: PMC4612538.

Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature-a role of β1-integrin in progenitor cell migration and adhesion
Nelson J, Wu Y, Jiang X, Berretta R, Houser S, Choi E, Wang J, Huang J, Yang X, Wang H. FASEB J. 2015 Jul;29(7):3085-99. doi: 10.1096/fj.14-267989. Epub 2015 Apr 8. PubMed PMID: 25854700; PubMed Central PMCID: PMC4478803.

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy
Liu X, Niu Y, Yuan H, Huang J, Fu L. Metabolism. 2015 Jun;64(6):658-65. doi: 10.1016/j.metabol.2015.01.015. Epub 2015 Jan 31. PubMed PMID: 25672217.

The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs
Land RH, Rayne AK, Vanderbeck AN, Barlowe TS, Manjunath S, Gross M, Eiger S, Klein PS, Cunningham NR, Huang J, Emerson SG, Punt JA. Stem Cells. 2015 Jan;33(1):278-88. doi: 10.1002/stem.1852. PubMed PMID: 25284014; PubMed Central PMCID: PMC4270858.

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish
Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS. Dis Model Mech. 2014 Jan;7(1):63-71. doi: 10.1242/dmm.012625. Epub 2013 Oct 2. PubMed PMID: 24092877; PubMed Central PMCID: PMC3882049.

T cell factor 1 is required for group 2 innate lymphoid cell generation
Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A. Immunity. 2013 Apr 18;38(4):694-704. doi: 10.1016/j.immuni.2012.12.003. PubMed PMID: 23601684; PubM3ed Central PMCID: PMC4029843.

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS. Nat Med. 2012 Dec;18(12):1778-85. doi: 10.1038/nm.2984. Epub 2012 Nov 11. PubMed PMID: 23142822; PubMed Central PMCID: PMC3518679.

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
O'Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, Klein PS. J Clin Invest. 2011 Sep;121(9):3756-62. doi: 10.1172/JCI45194. Epub 2011 Aug 8. PubMed PMID: 21821916; PubMed Central PMCID: PMC3163947.

Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice
Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS. J Clin Invest. 2009 Dec;119(12):3519-29. doi: 10.1172/JCI40572. PubMed PMID: 19959876; PubMed Central PMCID: PMC2786808.

Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder
Schloesser RJ, Huang J, Klein PS, Manji HK. Neuropsychopharmacology. 2008 Jan;33(1):110-33. doi: 10.1038/sj.npp.1301575. Epub 2007 Oct 3. Review. PubMed PMID: 17912251; NIHMSID:NIHMS309248.

ATP-dependent chromatin-remodeling complexes in DNA double-strand break repair: remodeling, pairing and (re)pairing
Huang J, Liang B, Qiu J, Laurent BC. Cell Cycle. 2005 Dec;4(12):1713-5. doi: 10.4161/cc.4.12.2222. Epub 2005 Dec 5. PubMed PMID: 16294042.

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair
Chai B, Huang J, Cairns BR, Laurent BC. Genes Dev. 2005 Jul 15;19(14):1656-61. doi: 10.1101/gad.1273105. PubMed PMID: 16024655; PubMed Central PMCID: PMC1176001.

A Role for the RSC chromatin remodeler in regulating cohesion of sister chromatid arms
Huang J, Laurent BC. Cell Cycle. 2004 Aug;3(8):973-5. Epub 2004 Aug 8. Review. PubMed PMID: 15254404.

The RSC nucleosome-remodeling complex is required for Cohesin's association with chromosome arms
Huang J, Hsu JM, Laurent BC. Mol Cell. 2004 Mar 12;13(5):739-50. doi: 10.1016/s1097-2765(04)00103-0. PubMed PMID: 15023343.

The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation
Hsu JM, Huang J, Meluh PB, Laurent BC. Mol Cell Biol. 2003 May;23(9):3202-15. doi: 10.1128/mcb.23.9.3202-3215.2003. PubMed PMID: 12697820; PubMed Central PMCID: PMC153182.