Available Products

The NIGMS Repository offers many different types of cell line and DNA products, as shown below. Please see the following product outline for more information about the cell lines and DNA products available from the Repository. View all catalog-available products here.


Cell Lines

  • Lymphoblastoid Cell Lines (LCLs)

    • Generated from the EBV transformation of lymphoblasts, derived from clinical peripheral blood samples. Genomic stability is maintained in the generation (PMID: 22374857), and expansion (PMID: 30075799) of these cell lines. Available as live cell cultures, frozen for a selection of samples, and cell pellets as a custom service.

    • See Lymphoblast Culture FAQ here.

    • View catalog-available LCLs from the NIGMS Repository.

  • Fibroblasts

    • Isolated from skin biopsy tissue samples and established as fibroblast cell lines in culture. Available as live cell cultures, frozen for a selection of samples, and as cell pellets as a custom service.

    • See Fibroblast Culture FAQ here.

    • View catalog-available fibroblasts from the NIGMS Repository.

  • Induced Pluripotent Stem Cells (iPSCs)

    • Created using various reprogramming techniques, and carefully monitored to adhere to rigorous quality control standards. iPSC lines are available for apparently healthy and disease specific parental lines. Isogenic controls of patient-derived samples have been generated using CRISPR/Cas-9. Each line is accompanied by a Certificate of Analysis and specific protocol for handling. Learn more here.

    • View catalog-available iPSCs from the NIGMS Repository.

  • Other Cell Types

    • Melanocytes: Isolated from foreskin tissue samples. Cell type is defined by histology, in which >80% of cells stain positive for HMB45 (gp100). Learn more here.

      • See Melanocyte Culture FAQ here.

    • Keratinocytes: Isolated from foreskin tissue samples. Cell type is defined by histology, in which >80% of cells stain positive for pancytokeratin. Learn more here.

      • See Keratinocyte Culture FAQ here.

    • Amniotic Fluid-Derived Cell Lines: Established from samples of amniotic fluid taken during fetal development.

      • See Amniotic Fluid-Derived Cell Line Culture FAQ here.

    • Human/Rodent Somatic Cell Hybrids: Generated by the fusion of human and rodent cell lines, and characterized by G-banded chromosome analysis and in situ hybridization. Learn more here.

    • View catalog-available other cell lines from the NIGMS Repository.

  • Formalin-Fixed Paraffin-Embedded (FFPE) scrolls

    • Prepared by the sectioning of cell pellets which have been embedded in paraffin wax and fixed by formalin. Designed for DNA extraction and genomic analysis alongside clinical FFPE samples. Learn more here.

    • View catalog-available FFPE scrolls from the NIGMS Repository.

  • Find more detailed definitions of all cell types here.

DNA Products

  • Individual DNA Vials

    • Isolated from cell cultures of the following cell types: LCL, Fibroblast, T-Lymphocyte, Whole Blood, Smooth Muscle, Amniotic Fluid-Derived, Tumor-Derived, Chorionic Villus-Derived, and Somatic Cell Hybrid. Available as individual DNA vials, and in bulk quantities as a custom service.

    • See additional information about DNA Quantitation here.

    • View catalog-available individual DNA from the NIGMS Repository.

  • DNA Panels/Plates/Pools

    • Mutation Panels (Thrombosis, Hemochromatosis, Cystic Fibrosis, Breast Cancer Information Core): Collection of complementary DNA samples that bear clinically relevant SNPs in genes that are associated with the respective disorder.

      • View catalog-available mutation panels from the NIGMS Repository.

    • CEPH Family Kit: Set of DNA samples from multiple individuals in a single family. Learn more here.

      • View catalog-available mutation panels from the NIGMS Repository.

    • Human Variation Panels

      • Regional Panels: Represents a collection of DNA from multiple individuals within a population. Available in sizes of 10, 50, 100, and 200 samples. See available regional populations here

        • View catalog-available human variation panels from the NIGMS Repository.

      • Nested Panels: Samples in these collections have been extensively characterized for genome-wide SNPs (PMID: 15718463). Available in sizes of 8, 16, 24 samples. Learn more here.

    • Reference Panels

      • SNP500: Set of reference DNA samples extracted from 102 LCLs representing four ethnically diverse groups (PMID: 14681474). Learn more here.

        • View product in catalog. 

      • CNV: Reference DNA samples isolated from 44 cell lines harboring a clinically significant chromosomal aberration. 

        • View product in catalog.

      • HLA: DNA samples extracted from 58 ethnically diverse cell lines that are relevant for testing human leukocyte antigen loci. Highly characterized as a part of the CDC Genetic Testing Reference Materials Coordination Program (GeT-RM) (PMID: 29959025). Learn more here

        • View product in catalog.

    • HapMap: Consists of samples that were used in the International HapMap Project to develop a haplotype map (“HapMap”) of the human genome. Learn more here

      • View catalog-available HapMap panels from the NIGMS Repository.

    • Human/Rodent Somatic Cell Hybrid Mapping Panels

      • Mapping Panel: Set of DNA isolated from human/rodent somatic cell hybrids that have retained between 1 and 19 human chromosomes. Learn more here.

        • View catalog-available mapping panels from the NIGMS Repository.

      • Regional Mapping Panel: Set of DNA isolated from human/rodent somatic cell hybrids that divide each chromosome into intervals.

        • View catalog-available regional mapping panels from the NIGMS Repository.

    • iPSC Parental Cell Line DNA: Set of DNA extracted from a diverse collection of cell lines from individuals that were apparently healthy and affected with heritable disease, used to create iPSCs with a variety of reprogramming techniques.

      • View product in catalog.

    • DNA Sample Pools: Pooled DNA sample that is the combination of equal quantities of DNA from a variety of sources. 

      • View catalog-available DNA sample pools from the NIGMS Repository.

    • View all catalog-available DNA panels/plates/pools from the NIGMS Repository.

    On-Demand Custom Services

    • Frozen Cell Pellets: Pelleted cell lines processed to be shipped frozen upon customer request and Repository approval. 

      • To order, place a Custom Service online order for the desired cell pellet, specifying the GM Reference ID (GM#####) of the cell line of interest, cell pellet size, and quantity under the "Cell Pellets" section

    • Cryopreserved Viable Cell Suspensions: Cell cultures that have been cyropreserved at maximum viability and are suitable for high molecular weight DNA extraction.

    • RNA: Extracted from catalog-available cell lines from the NIGMS Repository. RNA is stored frozen at -80°C and shipped to customers overnight on dry ice.

      • To order, place a Custom Service online order for the desired RNA, specifying the GM Reference ID (GM#####) of the cell line of interest and quantity under the "RNA on Demand" section

    • Bulk DNA: Unique, large quantity lots of DNA (>1 mg) extracted from catalog-available cell lines from the NIGMS Repository. 

      • To order, place a Custom Service online order for the desired DNA, specifying the GM Reference ID (GM#####) of the cell line of interest and quantity under the "Bulk DNA" section

    • Custom DNA Vials and Plates: Created from catalog-available DNA samples from the NIGMS Repository at customized concentrations and formats.

    • For any questions relating to On-Demand Custom Services, please contact us at SpecialServiceTeam@coriell.org