Longevity Collection

NIA Aging Cell Repository's Longevity Collection

For studies on successful aging, resources of lymphoblastoid cell lines(LCL) and LCL derived DNA samples from octogenarians, nonagenarians and centenarians are available from the NIA Aging Cell Repository. For each of these collections, the cell lines/DNA were prepared from blood samples that were donated by men and women who have reached great age and whose current health is good, though not necessarily completely healthy. Most donors were interviewed to collect critical information about their age, medical history, family medical history, and demographics. The samples include: 

• The 90+ Study
  
  The 90+ Study collection includes lymphoblastoid cell lines derived by Dr. R. Moyzis (Grady et al., 2013) from individuals aged ≥ 90 years who participated in the NIA-funded 90+ Study and Leisure World Cohort Study (Corrada et al., 2008; Paganini et al., 2011). Detailed information about the study can be found here.
  
  
• Aged Sib Pairs Collection
   
  The individuals listed in this collection were sought from elder care facilities in the US specifically because they are members of families with at least one other sibling who lived to be over the age of 80.
  
  
• Georgia Centenarian Collection 
  
  The Georgia Centenarian Collection includes DNA and lymphoblastoid cell lines from individuals from 98 to 108 years of age who were enrolled in the Georgia Centenarian Study. Young control individuals range in age from 20 to 59. The EBV-transformed cell lines were prepared from whole blood samples. DNA samples (10 micrograms) can be ordered individually or in panels. Samples are supplied with gender, race and age at time of collection. 

• Available information about the participants is summarized in a downloadable Excel file  with worksheets organized by race and age.

  DNA panels available:

  • White Panel of Great Age (N=100)
  • White Panel of Young Controls (N=100)
  • African American Panel of Great Age (N=32)
  • African American Panel of Young Controls (N=78)
  
  
• Gerontology Research Center Collection
  Lifetime Study Gerontology Research Center Collection
  
  This resource includes adult human skin fibroblast cultures from subjects participating in the Baltimore Longitudinal Study of Aging (BLSA). The BLSA was initiated to permit repeated observations of the same subjects over a long period of time to quantify true age changes and elucidate mechanisms underlying these changes. Observations documented include medical, genetic, biochemical, physiological, and behavioral variables. Information on the donor of any culture is available on request.
  
  The cultures from these subjects form a unique resource for cellular aging research because of the extensive database of medical measurements on each donor, the wide range of donor ages (from 17-96), and the availability of an in vitro lifespan measurement and karyotype for each culture.
  
  
• Longevity Research Collection
  
  Volunteers who had reached the age of 80 or older were sought from elder care facilities in the US for this research project. Subjects were interviewed with respect to medical history and lifestyle before sampling. The data are self-reported although every effort was made to verify their age. The detailed information about Longevity Research collection participants is summarized in a downloadable Excel File.
  
  
• Louisiana Healthy Aging Study
  
  The individuals listed in this collection came from Dr. S. Michal Jazwinski's research at Tulane University, which focuses on genetics of aging and population genetics. The samples came from individuals in the 60 - 100 years old age range.
  
  
• Sardinian Population of Great Age
  
  These individuals are from San Pietro, an island off the southwest coast of Sardinia where many residents attain a great age.
  
  
• Custom-made 96-well plates of DNA