NDPT106
96 WELL PLATE OF DNA SAMPLES
Description:
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE
Aliquot Size:
5 µg each
Sex:
Males: 46 Females: 46
Brief Description:
This panel contains 5 micrograms of DNA from 92 unique and unrelated White individuals with sporadic
amyotrophic lateral sclerosis (ALS). These include 46 males and 46 females from North America. The age of ALS onset
ranges from 41 years to 85 years. This was defined as when symptom(s) of ALS were first noted (including at least
one: lower motor neuron signs (LMN) including weakness, atrophy, fasciculations; upper motor neuron (UMN) signs
including spasticity, pathologic spread of reflexes, clonus, etc). Subjects represented on NDPT106 met
the El Escorial criteria for probable or possible, and were banked less than or equal to 6 years since ALS onset.
A more detailed description is also
available.
NDPT106 replaces NPDT028, and contains the same samples except: ND12890 (no longer available) and ND11814 (no longer
available)
are removed and are replaced by ND13782 and ND12709. ND11582 and ND12905 each appear twice on the panel as internal
controls. Wells D02 and E08 are empty for addition of a laboratory control.
Plate Layout:
The specific position on the plates has been optimized to reduce any
possible errors in
sample identity during the genotyping process.
| Abramzon Y, Johnson JO, Scholz SW, Taylor JP, Brunetti M, Calvo A, Mandrioli J, Benatar M, Mora G, Restagno G, Chiò A, Traynor BJ, Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis Neurobiology of aging33:2231.e1-6 2012 |
| PubMed ID: 22572540 |
| |
| Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD, Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis Neurology76:2062-5 2011 |
| PubMed ID: 21562248 |
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