Description:
TRANSLOCATED CHROMOSOME
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Chromosome Abnormalities |
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Cell Type
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Fibroblast
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Transformant
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Untransformed
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Race
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White
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Relation to Proband
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proband
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Confirmation
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Karyotypic analysis after cell line submission to CCR
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ISCN
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46,XX,t(6;18)(6pter>6q21::18p11>18pter; 18qter>18p11::6q21>6qter)
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| Passage Frozen |
7 |
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Chromosome Analysis |
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| Cytogenetics |
Chromosome 18: TRANSLOCATION Breakpoint 18p11 t(6;18)18p11 |
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Chromosome 6: TRANSLOCATION Breakpoint 6q21 t(6;18)6q21 |
| Remarks |
Phenotypically normal |
| Chong SS, Kristjansson K, Zoghbi HY, Hughes MR, Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Genomics18:355-359 1993 |
| PubMed ID: 8288239 |
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| Boyle JM, Hey Y, Myers K, Stern PL, Grzeschik FH, Ikehara Y, Misumi Y, Fox M, Regional localization of a trophoblast antigen-related sequence and 16 other sequences to human chromosomes 6q using somatic cell hybrids. Genomics12:693-8 1992 |
| PubMed ID: 1572643 |
| |
| Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR, Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics12:801-6 1992 |
| PubMed ID: 1315307 |
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| Ledley FD, Lumetta MR, Zoghbi HY, VanTuinen P, Ledbetter SA, Ledbetter DH, Mapping of human methylmalonyl CoA mutase (MUT) locus on chromosome 6. Am J Hum Genet42:839-46 1988 |
| PubMed ID: 2897160 |
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| Naylor SL, Sakaguchi AY, Shows TB, Grzeschik KH, Holmes M, Zasloff M, Two nonallelic tRNAiMet genes are located in the p23 leads to q12 region of human chromosome 6. Proc Natl Acad Sci U S A80:5027-31 1983 |
| PubMed ID: 6308668 |
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| Johannsmann R, Hellkuhl B, Grzeschik KH, Regional mapping of human chromosome 3. Assignment of a glutathione peroxidase-1 gene to 3p13 leads to 3q12. Hum Genet56:361-3 1981 |
| PubMed ID: 7239518 |
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| Grzeschik KH, Assignment of a structural gene for a fourth human diaphorase (DIA4) to chromosome 16 in man-mouse somatic cell hybrids. Hum Genet53:189-93 1980 |
| PubMed ID: 6928411 |
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| Klinger HP, Aronson MM, Greene AE, Coriell LL, A (6;18) translocation, 46 chromosomes. Repository identification No. GM-610. Cytogenet Cell Genet15:402-3 1975 |
| PubMed ID: 1225500 |
| Passage Frozen |
7 |
| Split Ratio |
1:3 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
trypsin-EDTA |
| Supplement |
- |
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