GM03714

GM03714 LCL from B-Lymphocyte

Description:

APPARENTLY HEALTHY INDIVIDUAL

Affected:

No

Sex:

Female

Age:

10 YR (At Sampling)

Overview

Repository

NIGMS Human Genetic Cell Repository

Subcollection

Apparently Healthy Collection

Biopsy Source

Peripheral vein

Cell Type

B-Lymphocyte

Tissue Type

Blood

Transformant

Epstein-Barr Virus

Sample Source

LCL from B-Lymphocyte

Race

White

Family Member

Relation to Proband

proband

Confirmation

Karyotypic analysis and Case history

Species

Homo sapiens

Common Name

Human

Remarks

Sister of GM03715; 46,XX; 2% of cells show random chromosome loss

Characterizations

IDENTIFICATION OF SPECIES OF ORIGIN

Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis

Phenotypic Data

Remarks

Sister of GM03715; 46,XX; 2% of cells show random chromosome loss

Publications

Innes CL, Heinloth AN, Flores KG, Sieber SO, Deming PB, Bushel PR, Kaufmann WK, Paules RS, ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts. Mol Cancer Res4(3):197-207 2006

PubMed ID: 16547157

Sotamaa K, Liyanarachchi S, Mecklin JP, Järvinen H, Aaltonen LA, Peltomäki P, de la Chapelle A, p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome Clinical cancer research : an official journal of the American Association for Cancer Research11:6840-4 2005

PubMed ID: 16203772

Barlow J, Yandell D, Weaver D, Casey T, Plaut K, Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors Breast cancer research and treatment79:149-59 2003

PubMed ID: 12825850

Deming PB, Cistulli CA, Zhao H, Graves PR, Piwnica-Worms H, Paules RS, Downes CS, Kaufmann WK, The human decatenation checkpoint. Proc Natl Acad Sci U S A98(21):12044-9 2001

PubMed ID: 11593014

Bentley KL, Li WL, VannBerg FO, Choi JY, Yu J, Kao FT, Ruano G, Detailed analysis of a 17q21 microdissection library by sequence bioinformatics and isolation of region-specific clones. Somat Cell Mol Genet23:353-65 1997

PubMed ID: 9580249

Yu J, Shen Y, Tong S, Kao FT, Assignment of three human markers in chromosome 21q11 to mouse chromosome 16. Somat Cell Mol Genet23:367-70 1997

PubMed ID: 9546078

Yu J, Tong S, Shen Y, Kao FT, Gene identification and DNA sequence analysis in the GC-poor 20 megabase region of human chromosome 21. Proc Natl Acad Sci U S A94:6862-7 1997

PubMed ID: 9192657

Kao FT, Tong S, Shen Y, Yu J, Construction and characterization of three region-specific microdissection libraries for human chromosome 18. Somat Cell Mol Genet22(3):191-9 1996

PubMed ID: 8914604

Kao FT, Tong S, Whittier A, Yu J, Complete set of eleven region-specific microdissection libraries for human chromosome 2. Somat Cell Mol Genet22:57-66 1996

PubMed ID: 8643994

Kim J, Chubatsu LS, Admon A, Stahl J, Fellous R, Linn S, Implication of mammalian ribosomal protein S3 in the processing of DNA damage. J Biol Chem270:13620-9 1995

PubMed ID: 7775413

Mirzayans R, Famulski KS, Enns L, Fraser M, Paterson MC, Characterization of the signal transduction pathway mediating gamma ray- induced inhibition of DNA synthesis in human cells: indirect evidence for involvement of calmodulin but not protein kinase C nor p53. Oncogene11:1597-605 1995

PubMed ID: 7478584

Yu J, Tong S, Whittier A, Kao FT, Three region-specific microdissection libraries for the long arm of human chromosome 2, regions q33-q35, q31-q32, and q23-q24. Somat Cell Mol Genet21:335-43 1995

PubMed ID: 8619130

McDonald TV, Nghiem PT, Gardner P, Martens CL, Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current. J Biol Chem267:3242-8 1992

PubMed ID: 1371114

Yu J, Tong S, Yang-Feng T, Kao FT, Construction and characterization of a region-specific microdissection library from human chromosome 2q35-q37. Genomics14:769-74 1992

PubMed ID: 1427905

Takai S, Price FM, Sanford KK, Tarone RE, Parshad R, Persistence of chromatid damage after G2 phase X-irradiation in lymphoblastoid cells from Gardner's syndrome. Carcinogenesis11:1425-8 1990

PubMed ID: 2387030

Tilley WD, Marcelli M, Wilson JD, McPhaul MJ, Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci U S A86:327-31 1989

PubMed ID: 2911578

Covey JM, D'Incalci M, Tilchen EJ, Zaharko DS, Kohn KW, Differences in DNA damage produced by incorporation of 5-aza-2'- deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells. Cancer Res46:5511-7 1986

PubMed ID: 2428479