Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Old Order Amish Major Affective Disorder
Heritable Diseases |
| Class |
Disorders of the Nervous System |
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Cell Type
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Fibroblast
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Transformant
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Untransformed
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Race
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White
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Ethnicity
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AMISH
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Family Member
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1
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| Passage Frozen |
10 |
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
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| Remarks |
Clinically affected; type II bipolar disorder (BPII); adult age of onset; semi-annual depressions lasting more than a week; hypomanic episodes; never treated; probably never psychotic; son (BPI) and several male siblings had bipolar disorder; see GM5963 Lymphoid |
| Yang S, Van Dongen HP, Wang K, Berrettini W, Bucan M, Assessment of circadian function in fibroblasts of patients with bipolar disorder Molecular psychiatry: 2008 |
| PubMed ID: 18301395 |
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| Yang S, Wang K, Gregory B, Berrettini W, Wang LS, Hakonarson H, Bucan M, Genomic landscape of a three-generation pedigree segregating affective disorder PLoS ONE4:e4474 2008 |
| PubMed ID: 19214233 |
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| Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Conte G, et al, Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish [see comments] Nature342:238-43 1989 |
| PubMed ID: 2682265 |
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| Goldman D, Goldin LR, Rathnagiri P, O'Brien SJ, Egeland JA, Merril CR, Twenty-seven protein polymorphisms by two-dimensional electrophoresis of serum, erythrocytes, and fibroblasts in two pedigrees. Am J Hum Genet37:898-911 1985 |
| PubMed ID: 3863481 |
| Passage Frozen |
10 |
| Split Ratio |
1:2 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
trypsin-EDTA |
| Supplement |
- |
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