GM11654
Tumor-derived cell line from Ewing sarcoma
Description:
EWING SARCOMA BREAKPOINT REGION 1; EWSR1, INCLUDED; EWS, INCLUDED; ES, INCLUDED
TRANSLOCATED CHROMOSOME
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Heritable Diseases
Chromosome Abnormalities |
| Class |
Heritable Cancer Syndromes and other Cancers |
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Biopsy Source
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Ewing sarcoma
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Cell Type
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Tumor-derived cell line
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Tissue Type
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Tumor
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Transformant
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Untransformed
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Sample Source
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Tumor-derived cell line from Ewing sarcoma
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Relation to Proband
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proband
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Confirmation
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Clinical summary/Case history
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ISCN
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46-84,X,+X,-Y,del(2)(q?),add(3)(q?), del(6)(q24),del(6)(q26),del(8)(p22), t(8;14)(q11;p11),t(11;22)(q24;q12){cp10}
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
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| Remarks |
Line TC71; Ewing sarcoma |
| Suvarna K, Jayabal P, Ma X, Wang H, Chen Y, Weintraub ST, Han X, Houghton PJ, Shiio Y, Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma Cell reports43:114497 2023 |
| PubMed ID: 39024100 |
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| Kim JA, Crawford KA, Spada PA, Martin LR, Zhang J, Wong R, Reid JM, Stewart CF, Frank TM, Liu Q, Michalek JE, Keller C, Non-chemotherapy adjuvant agents in TP53 mutant Ewing sarcoma Scientific reports13:14360 2022 |
| PubMed ID: 37658148 |
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| Jayabal P, Ma X, Shiio Y, EZH2 suppresses endogenous retroviruses and an interferon response in cancers Genes & cancer12:96-105 2021 |
| PubMed ID: 34966479 |
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| Jayabal P, Zhou F, Lei X, Ma X, Blackman B, Weintraub ST, Houghton PJ, Shiio Y, NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth Cell reports36:109254 2021 |
| PubMed ID: 34233189 |
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| Zhou F, Elzi DJ, Jayabal P, Ma X, Chiu YC, Chen Y, Blackman B, Weintraub ST, Houghton PJ, Shiio Y, GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth Cell reports33:108332 2020 |
| PubMed ID: 33147457 |
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| Whang-Peng J, Triche TJ, Knutsen T, Miser J, Kao-Shan S, Tsai S, Israel MA, Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet21:185-208 1986 |
| PubMed ID: 3004699 |
| Split Ratio |
1:6 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Percent O2 |
AMBIENT |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
10% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
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