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GM14106 LCL from B-Lymphocyte

Description:

KALLMANN SYN; HYPOGONADOTROPIC HYPOGONADISM, ANOSMIA- 147950, 244200, 308700

Affected:

Yes

Sex:

Male

Age:

44 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Heritable Diseases
dbGaP
Class Disorders of Steroid Metabolism
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source LCL from B-Lymphocyte
Race White
Relation to Proband proband
Confirmation Clinical summary/Case history
ISCN 46,XY.ish Xp22.3q28(KAL+,DXZ1+).arr(1-22)x2,(XY)x1
Species Homo sapiens
Common Name Human
Remarks Bilateral cleft lip and palate; hypogonadism and hypopituitarism; anosmia; hypermobile joints especially knees; brother has same clinical features except for cleft lip and palate; family history; molecular analysis detects no deletion in Kallman critical region on X

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks Bilateral cleft lip and palate; hypogonadism and hypopituitarism; anosmia; hypermobile joints especially knees; brother has same clinical features except for cleft lip and palate; family history; molecular analysis detects no deletion in Kallman critical region on X

Publications

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Tang Z, Berlin DS, Toji L, Toruner GA, Beiswanger C, Kulkarni S, Martin CL, Emanuel BS, Christman M, Gerry NP, A dynamic database of microarray-characterized cell lines with various cytogenetic and genomic backgrounds G3 (Bethesda, Md)3:1143-9 2013
PubMed ID: 23665875

External Links

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dbSNP dbSNP ID: 17097
Gene Cards KAL1
Gene Ontology GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0005578 extracellular matrix
GO:0005615 extracellular space
GO:0006928 cell motility
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0007411 axon guidance
NCBI Gene Gene ID:3730
NCBI GTR 147950 HYPOGONADOTROPIC HYPOGONADISM 2 WITH OR WITHOUT ANOSMIA; HH2
244200 HYPOGONADOTROPIC HYPOGONADISM 3 WITH OR WITHOUT ANOSMIA; HH3
308700 HYPOGONADOTROPIC HYPOGONADISM 1 WITH OR WITHOUT ANOSMIA; HH1
OMIM 147950 HYPOGONADOTROPIC HYPOGONADISM 2 WITH OR WITHOUT ANOSMIA; HH2
244200 HYPOGONADOTROPIC HYPOGONADISM 3 WITH OR WITHOUT ANOSMIA; HH3
308700 HYPOGONADOTROPIC HYPOGONADISM 1 WITH OR WITHOUT ANOSMIA; HH1
Omim Description HYPOGONADOTROPIC HYPOGONADISM AND ANOSMIA
  KALLMANN SYNDROME 2; KAL2
  HYPOGONADOTROPIC HYPOGONADISM AND ANOSMIA
  KALLMANN SYNDROME 3; KAL3
  ANOSMIC HYPOGONADISMADHESION MOLECULE-LIKE, X-LINKED, INCLUDED; ADMLX, INCLUDED
  ANOSMIN 1, INCLUDED
  DYSPLASIA OLFACTOGENITALIS OF DE MORSIER
  HYPOGONADOTROPIC HYPOGONADISM AND ANOSMIA; HHA
  KALLMANN SYNDROME 1; KAL1
  KALLMANN SYNDROME INTERVAL GENE 1; KALIG1
  KMS

Culture Protocols

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Split Ratio 1:5
Temperature 37 C
Percent CO2 5%
Medium Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not Inactivated
Substrate None specified
Subcultivation Method dilution - add fresh medium
Supplement -
Pricing
International/Commercial/For-profit:
$373.00USD
U.S. Academic/Non-profit/Government:
$216.00USD
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