GM02219

GM02219 LCL from B-Lymphocyte

Description:

ACUTE LYMPHOCYTIC LEUKEMIA

Affected:

Yes

Sex:

Male

Age:

19 YR (At Sampling)

Overview

Repository

NIGMS Human Genetic Cell Repository

Subcollection

Heritable Diseases
dbGaP

Class

Heritable Cancer Syndromes and other Cancers

Biopsy Source

Peripheral vein

Cell Type

T-Lymphocyte

Tissue Type

Blood

Transformant

Possibly Human T-cell Leukemia Virus

Sample Source

LCL from B-Lymphocyte

Relation to Proband

proband

Confirmation

Clinical summary/Case history

Species

Homo sapiens

Common Name

Human

Remarks

Line Molt-4; T lymphoblast cell line; all cells have 1p-, 6q-, 7p+, and an unknown marker chromosome; line is tetraploid; culture is positive for T cell 65,000 MW glycoprotein and negative for sIg and Ia (B cell) antigen

Characterizations

IDENTIFICATION OF SPECIES OF ORIGIN

Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis

Phenotypic Data

Remarks

Publications

Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP, A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res9:936-49 1999

PubMed ID: 10523522

Lattier DL, States JC, Hutton JJ, Wiginton DA, Cell type-specific transcriptional regulation of the human adenosine deaminase gene. Nucleic Acids Res17:1061-76 1989

PubMed ID: 2784203

Gan TE, Dadonna PE, Mitchell BS, Genetic expression of adenosine deaminase in human lymphoid malignancies. Blood69:1376-80 1987

PubMed ID: 3567360

Yemul S, Berger C, Estabrook A, Suarez S, Edelson R, Bayley H, Selective killing of T lymphocytes by phototoxic liposomes. Proc Natl Acad Sci U S A84:246-50 1987

PubMed ID: 3491992

Verhoef V, Fridland A, Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts. Cancer Res45:3646-50 1985

PubMed ID: 2410098

Wellner VP, Anderson ME, Puri RN, Jensen GL, Meister A, Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc Natl Acad Sci U S A81:4732-5 1984

PubMed ID: 6146978

Dalla-Favera R, Franchini G, Martinotti S, Wong-Staal F, Gallo RC, Croce CM, Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A79:4714-7 1982

PubMed ID: 6289315

Lane MA, Sainten A, Cooper GM, Stage-specific transforming genes of human and mouse B- and T- lymphocyte neoplasms. Cell28:873-80 1982

PubMed ID: 6284377

Daddona PE, Human adenosine deaminase. Properties and turnover in cultured T and B lymphoblasts. J Biol Chem256:12496-501 1981

PubMed ID: 6975278

Imai K, Galloway DR, Ferrone S, Serological and immunochemical analysis of the specificity of xenoantiserum 8986 elicited with hybrids between human melanoma cells and murine fibroblasts. Cancer Res41:1028-33 1981

PubMed ID: 6161692

Carrel S, Gross N, Salvi S, Rabbit antiserum against Daudi-cell membrane fractions detects cell surface antigens present on subpopulations of human lymphocytes. J Immunol120:1587-93 1978

PubMed ID: 307019

Royston I, Graze PR, Pitts RB, Failure of cultured human T-cell lymphoid lines to stimulate in mixed leukocyte culture. J Natl Cancer Inst53:361-7 1974

PubMed ID: 4276467

Takada A, Takada Y, Minowada J, Immunological functions of human T-lymphoid cell line (MOLT). I. Release of immunosuppressive factors from the mixture of MOLT-4 cells and sheep red blood cells. J Exp Med140:538-48 1974

PubMed ID: 4603015

Minowada J, Onuma T, Moore GE, Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst49:891-5 1972

PubMed ID: 4567231