GM05961
LCL from B-Lymphocyte
Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Old Order Amish Major Affective Disorder
Heritable Diseases |
| Class |
Disorders of the Nervous System |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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LCL from B-Lymphocyte
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Race
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White
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Ethnicity
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AMISH
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Family Member
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2
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
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| Remarks |
Some evidence of mild lability but no psychiatric diagnosis confirmed; one son has type I bipolar disorder (BPI); spouse of GM05963; see GM05960 Fibroblast; mother of GM05927 |
| Matsuzaki H, Dong S, Loi H, Di X, Liu G, Hubbell E, Law J, Berntsen T, Chadha M, Hui H, Yang G, Kennedy GC, Webster TA, Cawley S, Walsh PS, Jones KW, Fodor SP, Mei R, Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods1(2):109-11 2004 |
| PubMed ID: 15782172 |
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| Dong S, Wang E, Hsie L, Cao Y, Chen X, Gingeras TR, Flexible use of high-density oligonucleotide arrays for single-nucleotide polymorphism discovery and validation. Genome Res11(8):1418-24 2001 |
| PubMed ID: 11483583 |
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| Vincent JB, Neves-Pereira ML, Paterson AD, Yamamoto E, Parikh SV, Macciardi
F, Gurling HM, Potkin SG, Pato CN, Macedo A, Kovacs M, Davies M, Lieberman JA,
Meltzer HY, Petronis A, Kennedy JL, An unstable trinucleotide-repeat region on chromosome 13 implicated in
spinocerebellar ataxia: a common expansion locus. Am J Hum Genet66(3):819-29 2000 |
| PubMed ID: 10712198 |
| |
| Bowman ED, Bromeke B, Lensing W, Shields PG, Apolipoprotein E allelic frequency in elderly smokers. Am J Med Genet76(1):32-6 1998 |
| PubMed ID: 9508061 |
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| Lisitsyn N, Lisitsyn N, Wigler M, Cloning the differences between two complex genomes. Science259:946-51 1993 |
| PubMed ID: 8438152 |
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| Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Conte G, et al, Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish [see comments] Nature342:238-43 1989 |
| PubMed ID: 2682265 |
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| Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE, Bipolar affective disorders linked to DNA markers on chromosome 11. Nature325:783-7 1987 |
| PubMed ID: 2881209 |
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| Gerhard DS, Kidd KK, Kidd JR, Egeland JA, Housman DE, Identification of a recent recombination event within the human beta- globin gene cluster. Proc Natl Acad Sci U S A81:7875-9 1984 |
| PubMed ID: 6096866 |
| Split Ratio |
1:3 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not Inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
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