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GM05975 LCL from B-Lymphocyte

Description:

MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200

Affected:

No

Sex:

Female

Age:

55 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Images
  • Culture Protocols

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Old Order Amish Major Affective Disorder
Heritable Diseases
Class Disorders of the Nervous System
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source LCL from B-Lymphocyte
Race White
Ethnicity AMISH
Family Member 9
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks Clinically unaffected; one affected brother; affected son is GM05977 (BPI); spouse of GM05973; see GM05974 Fibroblast; daughter of GM05963 and GM05961

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase Isoenzyme Electrophoresis
 
GENE MAPPING & DOSAGE STUDIES - Y CHROMOSOME PCR analysis of DNA from this cell culture gave a negative result with a primer for Yq11, DYS227.
 

Phenotypic Data

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Remarks Clinically unaffected; one affected brother; affected son is GM05977 (BPI); spouse of GM05973; see GM05974 Fibroblast; daughter of GM05963 and GM05961

Publications

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Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Conte G, et al, Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish [see comments] Nature342:238-43 1989
PubMed ID: 2682265
 
Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE, Bipolar affective disorders linked to DNA markers on chromosome 11. Nature325:783-7 1987
PubMed ID: 2881209
 
Gerhard DS, Kidd KK, Kidd JR, Egeland JA, Housman DE, Identification of a recent recombination event within the human beta- globin gene cluster. Proc Natl Acad Sci U S A81:7875-9 1984
PubMed ID: 6096866

External Links

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dbSNP dbSNP ID: 761
Gene Cards MAFD1
MAFD2
NCBI Gene Gene ID:4095
Gene ID:4096
NCBI GTR 125480 MAJOR AFFECTIVE DISORDER 1; MAFD1
309200 MAJOR AFFECTIVE DISORDER 2; MAFD2
OMIM 125480 MAJOR AFFECTIVE DISORDER 1; MAFD1
309200 MAJOR AFFECTIVE DISORDER 2; MAFD2
Omim Description AFFECTIVE DISORDER
  BIPOLAR AFFECTIVE DISORDER; BPAD
  DEPRESSIVE DISORDER
  MAJOR AFFECTIVE DISORDER 1; MAFD1
  MANIC-DEPRESSIVE PSYCHOSIS, AUTOSOMAL
  MANIC-DEPRESSIVE PSYCHOSIS; MD1
  BIPOLAR AFFECTIVE DISORDER; BPAD
  MAJOR AFFECTIVE DISORDER 2; MAFD2
  MANIC-DEPRESSIVE ILLNESS; MDI
  MANIC-DEPRESSIVE PSYCHOSIS, X-LINKED
  MDX

Images

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View pedigree 

Culture Protocols

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Split Ratio 1:4
Temperature 37 C
Percent CO2 5%
Medium Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not Inactivated
Substrate None specified
Subcultivation Method dilution - add fresh medium
Supplement -
Pricing
International/Commercial/For-profit:
$373.00USD
U.S. Academic/Non-profit/Government:
$216.00USD
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How to Order
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