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GM25256 iPSC from Fibroblast

Description:

APPARENTLY HEALTHY INDIVIDUAL

Affected:

No

Sex:

Male

Age:

30 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • Culture Protocols

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Apparently healthy iPSCs
Apparently Healthy Collection
Protocols Protocol PDF
Biopsy Source Skin
Cell Type Stem cell
Cell Subtype Induced pluripotent stem cell
Transformant Reprogrammed (Episomal)
Sample Source iPSC from Fibroblast
Race Asian
Ethnicity Not Hispanic/Latino
Ethnicity Japanese
Country of Origin USA
Family Member 1
Family History N
Relation to Proband proband
Confirmation Karyotypic analysis before cell line submission to CCR
ISCN 46,XY[20]
Species Homo sapiens
Common Name Human
Remarks Induced pluripotent stem cell line derived from adult skin (leg) fibroblasts; subject clinically normal; wild-type; FISH test: 46, XY. This iPSC line (WTC-11) was submitted by Dr. Bruce R. Conklin (Gladstone Institute of Cardiovascular Disease, UCSF) and may serve as a control for diseased iPSCs GM25267 (LQT2) iPSC and GM25305 (LQT3); also available is a collection of fluorescently tagged hiPSC lines from the same subject, using CRISPR/Cas9 technology (for more information, see the Allen Cell Collection at Coriell: https://catalog.coriell.org/1/AllenCellCollection). Researchers purchasing hiPSCs from the NIGMS Repository are responsible for any limited use label licenses (LULLs) applicable to the cell line purchased. The applicable LULL to this line is iPS Academia, Japan Inc..

Characterizations

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Passage Frozen 40
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by LINE assay
 
Induced Pluripotent Stem Cell The frozen cell line submitted to the Repository was recovered and expanded. The expanded line was evaluated for viability surface antigen expression and alkaline phosphatase activity. Pluripotency was assessed via embryoid body (EB) formation. Steady-state mRNA expression patterns of undifferentiated iPSC and EBs were determined via real-time PCR. Characterization data are included in the Certificate of Analysis.
 

Phenotypic Data

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Remarks Induced pluripotent stem cell line derived from adult skin (leg) fibroblasts; subject clinically normal; wild-type; FISH test: 46, XY. This iPSC line (WTC-11) was submitted by Dr. Bruce R. Conklin (Gladstone Institute of Cardiovascular Disease, UCSF) and may serve as a control for diseased iPSCs GM25267 (LQT2) iPSC and GM25305 (LQT3); also available is a collection of fluorescently tagged hiPSC lines from the same subject, using CRISPR/Cas9 technology (for more information, see the Allen Cell Collection at Coriell: https://catalog.coriell.org/1/AllenCellCollection). Researchers purchasing hiPSCs from the NIGMS Repository are responsible for any limited use label licenses (LULLs) applicable to the cell line purchased. The applicable LULL to this line is iPS Academia, Japan Inc..

Publications

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Cao H, Yue L, Shao J, Kong F, Liu S, Huai H, He Z, Mao Z, Yang Y, Tan Y, Wang H, Small extracellular vesicles derived from umbilical cord mesenchymal stem cells alleviate radiation-induced cardiac organoid injury Stem cell research & therapy15:493 2024
PubMed ID: 39707562
 
Fatima N, Dillen L, Hommersom MP, Çepni E, Fatima F, van Beusekom E, Albert S, Ali Khan A, de Brouwer APM, van Bokhoven H, Generation of induced pluripotent stem cell line (UCSFi001-A-77) carrying a biallelic frameshift variant in exon 4 of SGIP1 through CRISPR/Cas9 Stem cell research80:103511 2024
PubMed ID: 39098170
 
Hwang DG, Choi H, Yong U, Kim D, Kang W, Park SM, Jang J, Bioprinting-Assisted Tissue Assembly for Structural and Functional Modulation of Engineered Heart Tissue Mimicking Left Ventricular Myocardial Fiber Orientation Advanced materials (Deerfield Beach, Fla)80:e2400364 2024
PubMed ID: 38717016
 
Lim SW, Lee KI, Cui S, Fang X, Shin YJ, Lee H, Lee JY, Chung BH, Yang CW, Generation of green fluorescent protein reporter knock-in iPSC line at the 3'UTR region of the KLOTHO locus Stem cell research80:103499 2024
PubMed ID: 39111000
 
Mathis D, Koch J, Koller S, Sauter K, Flück C, Uldry AC, Forny P, Froese DS, Laemmle A, Induced pluripotent stem cell-derived hepatocytes reveal TCA cycle disruption and the potential basis for triheptanoin treatment for malate dehydrogenase 2 deficiency Molecular genetics and metabolism reports39:101066 2024
PubMed ID: 38425868
 
Parodi G, Zanini G, Collo L, Impollonia R, Cervetto C, Frega M, Chiappalone M, Martinoia S, In vitro electrophysiological drug testing on neuronal networks derived from human induced pluripotent stem cells Stem cell research & therapy15:433 2024
PubMed ID: 39551784
 
Prondzynski M, Bortolin RH, Berkson P, Trembley MA, Shani K, Sweat ME, Mayourian J, Cordoves AM, Anyanwu NJ, Tharani Y, Cotton J, Milosh JB, Walker D, Zhang Y, Liu F, Liu X, Parker KK, Bezzerides VJ, Pu WT, Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor bioRxiv : the preprint server for biology15:433 2024
PubMed ID: 38464269
 
Qi L, Groeger M, Sharma A, Goswami I, Chen E, Zhong F, Ram A, Healy K, Hsiao EC, Willenbring H, Stahl A, Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system Nature communications15:7991 2024
PubMed ID: 39266553
 
Rahimov F, Nieminen P, Kumari P, Juuri E, Nikopensius T, Paraiso K, German J, Karvanen A, Kals M, Elnahas AG, Karjalainen J, Kurki M, Palotie A, FinnGen A, Estonian Biobank Research Team A, Heliövaara A, Esko T, Jukarainen S, Palta P, Ganna A, Patni AP, Mar D, Bomsztyk K, Mathieu J, Ruohola-Baker H, Visel A, Fakhouri WD, Schutte BC, Cornell RA, Rice DP, High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene Nature communications15:9568 2024
PubMed ID: 39500877
 
Voogd EJHF, Thijs M, Levers MR, Hofmeijer J, Frega M, Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation PloS one19:e0314913 2024
PubMed ID: 39705243
 
Woo Lim S, In Lee K, Cui S, Fang X, Jin Shin Y, Lee H, Woo Yang C, Young Lee J, Ha Chung B, Generation of a human SLC12A3 knock-in human induced pluripotent stem cell line (CMCi014-A-82) using CRISPR-Cas9 system Stem cell research81:103522 2024
PubMed ID: 39163808
 
Yang P, Zhu L, Wang S, Gong J, Selvaraj JN, Ye L, Chen H, Zhang Y, Wang G, Song W, Li Z, Cai L, Zhang H, Zhang D, Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions Nature communications15:7996 2024
PubMed ID: 39266508
 
Alghadeer A, Patni AP, Li Z, Lim YC, Mathieu J, Ruohola-Baker H, Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors STAR protocols5:103100 2023
PubMed ID: 38824640
 
Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CX, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA, Birth Defects Research Laboratory IA, Stratton JA, Fon E, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM, MerTK is a mediator of alpha-synuclein fibril uptake by human microglia Brain : a journal of neurology5:103100 2023
PubMed ID: 37671615
 
Dyke E, Bijnagte-Schoenmaker C, Wu KM, Oudakker A, Roepman R, Nadif Kasri N, Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9 Stem cell research68:103053 2023
PubMed ID: 36842376
 
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C, Generation of complex bone marrow organoids from human induced pluripotent stem cells Nature methods68:103053 2023
PubMed ID: 38374263
 
Geben LC, Brockman AA, Chalkley MBL, Sweet SR, Gallagher JE, Scheuing AL, Simerly RB, Ess KC, Irish JM, Ihrie RA, Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence bioRxiv : the preprint server for biology68:103053 2023
PubMed ID: 36824760
 
Guo J, Jiang H, Schuftan D, Moreno JD, Ramahdita G, Aryan L, Bhagavan D, Silva J, Huebsch N, Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy iScience27:109954 2023
PubMed ID: 38827401
 
Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L, Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons bioRxiv : the preprint server for biology27:109954 2023
PubMed ID: 36865171
 
Juliar BA, Stanaway IB, Sano F, Fu H, Smith KD, Akilesh S, Scales SJ, El Saghir J, Bhatraju PK, Liu E, Yang J, Lin J, Eddy S, Kretzler M, Zheng Y, Himmelfarb J, Harder JL, Freedman BS, Interferon-? induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease Cell reports43:114310 2023
PubMed ID: 38838223
 
Karbassi E, Padgett R, Bertero A, Reinecke H, Klaiman JM, Yang X, Hauschka SD, Murry CE, Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium Cellular and molecular life sciences : CMLS81:95 2023
PubMed ID: 38372898
 
Lavekar SS, Harkin J, Hernandez M, Gomes C, Patil S, Huang KC, Puntambekar SS, Lamb BT, Meyer JS, Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease Scientific reports13:13827 2023
PubMed ID: 37620502
 
Mijdam R, Bijnagte-Schoenmaker C, Dyke E, Moons SJ, Boltje TJ, Nadif Kasri N, Lefeber DJ, Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons Journal of neurochemistry167:76-89 2023
PubMed ID: 37650222
 
Oguntuyo K, Schuftan D, Guo J, Simmons D, Bhagavan D, Moreno JD, Kang PW, Miller E, Silva JR, Huebsch N, Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity Tissue engineering Part C, Methods28:457-468 2023
PubMed ID: 35925789
 
Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP, A CRISPR-engineered isogenic model of the 22q112 A-B syndromic deletion Scientific reports13:7689 2023
PubMed ID: 37169815
 
Parodi G, Brofiga M, Pastore VP, Chiappalone M, Martinoia S, Deepening the role of excitation/inhibition balance in human iPSCs-derived neuronal networks coupled to MEAs during long-term development Journal of neural engineering20:7689 2023
PubMed ID: 37678214
 
Podlesny-Drabiniok A, Novikova G, Liu Y, Dunst J, Temizer R, Giannarelli C, Marro S, Kreslavsky T, Marcora E, Goate AM, BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues Nature communications15:2058 2023
PubMed ID: 38448474
 
Prondzynski M, Berkson P, Trembley MA, Tharani Y, Shani K, Bortolin RH, Sweat ME, Mayourian J, Yucel D, Cordoves AM, Gabbin B, Hou C, Anyanwu NJ, Nawar F, Cotton J, Milosh J, Walker D, Zhang Y, Lu F, Liu X, Parker KK, Bezzerides VJ, Pu WT, Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems Nature communications15:5929 2023
PubMed ID: 39009604
 
Simmons DW, Malayath G, Schuftan DR, Guo J, Oguntuyo K, Ramahdita G, Sun Y, Jordan SD, Munsell MK, Kandalaft B, Pear M, Rentschler SL, Huebsch N, Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes APL bioengineering8:016118 2023
PubMed ID: 38476404
 
Simmons DW, Schuftan DR, Ramahdita G, Huebsch N, Hydrogel-Assisted Double Molding Enables Rapid Replication of Stereolithographic 3D Prints for Engineered Tissue Design ACS applied materials & interfaces15:25313-25323 2023
PubMed ID: 37200617
 
Sirbu A, Bathe-Peters M, Kumar JLM, Inoue A, Lohse MJ, Annibale P, Cell swelling enhances ligand-driven ß-adrenergic signaling Nature communications15:7822 2023
PubMed ID: 39242606
 
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy SC, Janssens RC, Somsen HB, Ramadhin AR, Dekkers DHW, Wienecke HL, Demmers JJPG, Raams A, Davó-Martínez C, Llerena Schiffmacher DA, van Toorn M, Häckes D, Thijssen KL, Zhou D, Lammers JG, Pines A, Vermeulen W, Pothof J, Demmers JAA, van den Berg DLC, Lans H, Marteijn JA, Transcription-coupled DNA-protein crosslink repair by CSB and CRL4 Nature cell biology15:7822 2023
PubMed ID: 38600236
 
Wesley CC, Levy DL, Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization Molecular biology of the cell34:ar10 2023
PubMed ID: 36598800
 
Youn J, Rhyou J, Kim D, Lee J, Choi JW, Park TE, Kim DS, Facile and adhesive-free method for bonding nanofiber membrane onto thermoplastic polystyrene substrate to fabricate 3D cell culture platforms Materials today Bio20:100648 2023
PubMed ID: 37214546
 
Zanini G, Parodi G, Chiappalone M, Martinoia S, Investigating the reliability of the evoked response in human iPSCs-derived neuronal networks coupled to micro-electrode arrays APL bioengineering7:046121 2023
PubMed ID: 38130601
 
Zenk F, Fleck JS, Jansen SMJ, Kashanian B, Eisinger B, Santel M, Dupré JS, Camp JG, Treutlein B, Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems Nature neuroscience7:046121 2023
PubMed ID: 38914828
 
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN, Noncanonical function of folate through folate receptor 1 during neural tube formation Nature communications15:1642 2022
PubMed ID: 38388461
 
Barnes AM, Holmstoen TB, Bonham AJ, Rowland TJ, Differentiating Human Pluripotent Stem Cells to Cardiomyocytes Using Purified Extracellular Matrix Proteins Bioengineering (Basel, Switzerland)9:1642 2022
PubMed ID: 36550926
 
Bauer L, Rissmann M, Benavides FFW, Leijten L, van Run P, Begeman L, Veldhuis Kroeze EJB, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Koopmans MPG, Rockx B, van Riel D, In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants Acta Neuropathol Communications10:1642 2022
PubMed ID: 36058935
 
Charwat V, Charrez B, Siemons BA, Finsberg H, Jæger KH, Edwards AG, Huebsch N, Wall S, Miller E, Tveito A, Healy KE, Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System ACS pharmacology & translational science5:652-667 2022
PubMed ID: 35983280
 
Dorion MF, Yaqubi M, Murdoch HJ, Hall JA, Dudley R, Antel JP, Durcan TM, Healy LM, Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling Glia71:1278-1293 2022
PubMed ID: 36680780
 
Goddi A, Carmona A, Park SY, Dalgin G, Gonzalez Porras MA, Brey EM, Cohen RN, Laminin-a4 Negatively Regulates Adipocyte Beiging Through the Suppression of AMPKa in Male Mice Endocrinology163:1278-1293 2022
PubMed ID: 36124842
 
Hommersom MP, Bijnagte-Schoenmaker C, Albert S, van de Warrenburg BPC, Nadif Kasri N, van Bokhoven H, Generation of induced pluripotent stem cell lines carrying monoallelic (UCSFi001-A-60) or biallelic (UCSFi001-A-61; UCSFi001-A-62) frameshift variants in CACNA1A using CRISPR/Cas9 Stem cell research61:102730 2022
PubMed ID: 35286975
 
Kaul H, Werschler N, Jones RD, Siu MM, Tewary M, Hagner A, Ostblom J, Aguilar-Hidalgo D, Zandstra PW, Virtual cells in a virtual microenvironment recapitulate early development-like patterns in human pluripotent stem cell colonies Stem cell reports18:377-393 2022
PubMed ID: 36332630
 
Khayrullina G, Alipio-Gloria ZA, Deguise MO, Gagnon S, Chehade L, Stinson M, Belous N, Bergman EM, Lischka FW, Rotty J, Dalgard CL, Kothary R, Johnson KA, Burnett BG, Survival motor neuron protein deficiency alters microglia reactivity Glia70:1337-1358 2022
PubMed ID: 35373853
 
Kornienko J, Rodríguez-Martínez M, Fenzl K, Hinze F, Schraivogel D, Grosch M, Tunaj B, Lindenhofer D, Schraft L, Kueblbeck M, Smith E, Mao C, Brown E, Owens A, Saguner AM, Meder B, Parikh V, Gotthardt M, Steinmetz LM, Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3 Nature communications14:4312 2022
PubMed ID: 37463913
 
Li SR, Gulieva RE, Helms L, Cruz NM, Vincent T, Fu H, Himmelfarb J, Freedman BS, Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease Nature communications13:7918 2022
PubMed ID: 36564419
 
Mills C, Riching A, Keller A, Stombaugh J, Haupt A, Maksimova E, Dickerson SM, Anderson E, Hemphill K, Ebmeier C, Schiel JA, Levenga J, Perkett M, Smith AVB, Strezoska Z, A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs The CRISPR journal5:769-786 2022
PubMed ID: 36257604
 
Schimmel J, Muñoz-Subirana N, Kool H, van Schendel R, van der Vlies S, Kamp JA, de Vrij F, Kushner SA, Smith GCM, Boulton SJ, Tijsterman M, Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways Cell reports42:112019 2022
PubMed ID: 36701230
 
Schneider O, Moruzzi A, Fuchs S, Grobel A, Schulze HS, Mayr T, Loskill P, Fusing spheroids to aligned µ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities Materials today Bio15:100280 2022
PubMed ID: 35601892
 
Wu JY, Yeager K, Tavakol DN, Morsink M, Wang B, Soni RK, Hung CT, Vunjak-Novakovic G, Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-ß signaling Cell reports42:112509 2022
PubMed ID: 37178118
 
Aisenbrey EA, Torr E, Johnson H, Soref C, Daly W, Murphy WL, A protocol for rapid pericyte differentiation of human induced pluripotent stem cells STAR protocols2:100261 2021
PubMed ID: 33490977
 
Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H, NYGC ALS Consortium H, Newcombe J, Gustavsson EK, Seddighi S, Reyes JF, Coon SL, Ramos D, Schiavo G, Fisher EMC, Raj T, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P, TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A Nature603:131-137 2021
PubMed ID: 35197628
 
Budjan C, Liu S, Ranga A, Gayen S, Pourquié O, Hormoz S, Paraxial mesoderm organoids model development of human somites eLife11:131-137 2021
PubMed ID: 35088712
 
Charrez B, Charwat V, Siemons BA, Goswami I, Sakolish C, Luo YS, Finsberg H, Edwards AG, Miller EW, Rusyn I, Healy KE, Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics Frontiers in pharmacology12:684252 2021
PubMed ID: 34421592
 
Christopher GA, Noort RJ, Esseltine JL, Connexin 43 Gene Ablation Does Not Alter Human Pluripotent Stem Cell Germ Lineage Specification Biomolecules12:684252 2021
PubMed ID: 35053163
 
Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M, A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states Nature neuroscience25:1149-1162 2021
PubMed ID: 35953545
 
Fort L, Gama V, Macara IG, Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells Nature cell biology24:434-447 2021
PubMed ID: 35414019
 
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, Battaglioli E, Passafaro M, Bassani S, The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes Cell reports39:110857 2021
PubMed ID: 35613587
 
Guo J, Jiang H, Oguntuyo K, Rios B, Boodram Z, Huebsch N, Interplay of Genotype and Substrate Stiffness in Driving the Hypertrophic Cardiomyopathy Phenotype in iPSC-Micro-Heart Muscle Arrays Cellular and molecular bioengineering14:409-425 2021
PubMed ID: 34777601
 
He Z, Maynard A, Jain A, Gerber T, Petri R, Lin HC, Santel M, Ly K, Dupré JS, Sidow L, Sanchis Calleja F, Jansen SMJ, Riesenberg S, Camp JG, Treutlein B, Lineage recording in human cerebral organoids Nature methods19:90-99 2021
PubMed ID: 34969984
 
Helms L, Marchiano S, Stanaway IB, Hsiang TY, Juliar BA, Saini S, Zhao YT, Khanna A, Menon R, Alakwaa F, Mikacenic C, Morrell ED, Wurfel MM, Kretzler M, Harder JL, Murry CE, Himmelfarb J, Ruohola-Baker H, Bhatraju PK, Gale M, Freedman BS, Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI insight6:90-99 2021
PubMed ID: 34767537
 
King O, Cruz-Moreira D, Sayed A, Kermani F, Kit-Anan W, Sunyovszki I, Wang BX, Downing B, Fourre J, Hachim D, Randi AM, Stevens MM, Rasponi M, Terracciano CM, Functional microvascularization of human myocardium Cell reports methods2:100280 2021
PubMed ID: 36160044
 
Kuramochi Y, Awaya T, Matsuo-Takasaki M, Takami M, An Y, Li J, Hemmi Y, Wakabayashi T, Arai Y, Inoue J, Noguchi M, Nakamura Y, Asaka I, Akimoto K, Saito MK, Hayashi Y, Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations Stem cell research53:102337 2021
PubMed ID: 33901816
 
Muzzi L, Di Lisa D, Arnaldi P, Aprile D, Pastorino L, Martinoia S, Frega M, Rapid generation of functional engineered 3D human neuronal assemblies: network dynamics evaluated by micro-electrodes arrays Journal of neural engineering18:102337 2021
PubMed ID: 34844234
 
Notaras M, Lodhi A, Barrio-Alonso E, Foord C, Rodrick T, Jones D, Fang H, Greening D, Colak D, Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids Molecular psychiatry18:102337 2021
PubMed ID: 34158620
 
Pires Monteiro S, Voogd E, Muzzi L, De Vecchis G, Mossink B, Levers M, Hassink G, Van Putten M, Le Feber J, Hofmeijer J, Frega M, Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra Journal of neural engineering18:036016 2021
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Williams LM, Fujimoto T, Weaver RR, Logsdon AF, Evitts KM, Young JE, Banks WA, Erickson MA, Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu Fluids and barriers of the CNS19:10 2021
PubMed ID: 35123529
 
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R, Adult human kidney organoids originate from CD24 Nature genetics54:1690-1701 2021
PubMed ID: 36303074
 
Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T, DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics54:1690-1701 2021
PubMed ID: 34160773
 
Zinger A, Cvetkovic C, Sushnitha M, Naoi T, Baudo G, Anderson M, Shetty A, Basu N, Covello J, Tasciotti E, Amit M, Xie T, Taraballi F, Krencik R, Humanized Biomimetic Nanovesicles for Neuron Targeting Advanced science (Weinheim, Baden-Wurttemberg, Germany)54:e2101437 2021
PubMed ID: 34382379
 
Arai Y, Takami M, An Y, Matsuo-Takasaki M, Hemmi Y, Wakabayashi T, Inoue J, Noguchi M, Nakamura Y, Sugimoto K, Takemura T, Okita K, Osafune K, Takasato M, Hayata T, Hayashi Y, Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion Stem cell research45:101815 2020
PubMed ID: 32361464
 
Jæger KH, Charwat V, Wall S, Healy KE, Tveito A, Identifying Drug Response by Combining Measurements of the Membrane Potential, the Cytosolic Calcium Concentration, and the Extracellular Potential in Microphysiological Systems Frontiers in pharmacology11:569489 2020
PubMed ID: 33628168
 
Levy S, Somasundaram L, Raj IX, Ic-Mex D, Phal A, Schmidt S, Ng WI, Mar D, Decarreau J, Moss N, Alghadeer A, Honkanen H, Sarthy J, Vitanza A, Hawkins RD, Mathieu J, Wang Y, Baker D, Bomsztyk K, Ruohola-Baker H, dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region Cell reports38:110457 2020
PubMed ID: 35235780
 
Libby ARG, Joy DA, McDevitt TC, Engineering the Spatiotemporal Mosaic Self-Patterning of Pluripotent Stem Cells Methods in molecular biology (Clifton, NJ)2258:105-116 2020
PubMed ID: 33340357
 
Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM, Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder Nature communications13:3243 2020
PubMed ID: 35688811
 
Liu LP, Guo NN, Li YM, Zheng YW, Generation of Human iMelanocytes from Induced Pluripotent Stem Cells through a Suspension Culture System STAR protocols1:100004 2020
PubMed ID: 33111066
 
Long Y, Cech TR, Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools Methods (San Diego, Calif)191:44-58 2020
PubMed ID: 33444739
 
Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR, RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells Nature genetics191:44-58 2020
PubMed ID: 32632336
 
Middelkamp HHT, Verboven AHA, De Sá Vivas AG, Schoenmaker C, Klein Gunnewiek TM, Passier R, Albers CA, 't Hoen PAC, Nadif Kasri N, van der Meer AD, Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips Scientific reports11:2281 2020
PubMed ID: 33500551
 
Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS, Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing Cell184:2503-2519.e17 2020
PubMed ID: 33838111
 
Ortolano NA, Romero-Morales AI, Rasmussen ML, Bodnya C, Kline LA, Joshi P, Connelly JP, Rose KL, Pruett-Miller SM, Gama V, A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models PloS one16:e0248000 2020
PubMed ID: 33705438
 
Tsan YC, DePalma SJ, Zhao YT, Capilnasiu A, Wu YW, Elder B, Panse I, Ufford K, Matera DL, Friedline S, O'Leary TS, Wubshet N, Ho KKY, Previs MJ, Nordsletten D, Isom LL, Baker BM, Liu AP, Helms AS, Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform Nature communications12:6167 2020
PubMed ID: 34697315
 
Youmans DT, Gooding AR, Dowell RD, Cech TR, Competition between PRC21 and 22 subcomplexes regulates PRC2 chromatin occupancy in human stem cells Molecular cell12:6167 2020
PubMed ID: 33338397
 
Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y, Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms Human molecular genetics12:6167 2020
PubMed ID: 32879944
 
Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M, Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway Nature579:427-432 2019
PubMed ID: 32132707
 
Kim E, Wu F, Wu X, Choo HJ, Generation of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration Biomaterials248:119995 2019
PubMed ID: 32283390
 
Li L, Li Y, Sottas C, Culty M, Fan J, Hu Y, Cheung G, Chemes HE, Papadopoulos V, Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells Proceedings of the National Academy of Sciences of the United States of America248:119995 2019
PubMed ID: 31591190
 
Libby ARG, Briers D, Haghighi I, Joy DA, Conklin BR, Belta C, McDevitt TC, Automated Design of Pluripotent Stem Cell Self-Organization Cell systems9:483-495.e10 2019
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Madsen RR, Semple RK, Luminescent peptide tagging enables efficient screening for CRISPR-mediated knock-in in human induced pluripotent stem cells Wellcome open research4:37 2019
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Nickolls AR, Lee MM, Espinoza DF, Szczot M, Lam RM, Wang Q, Beers J, Zou J, Nguyen MQ, Solinski HJ, AlJanahi AA, Johnson KR, Ward ME, Chesler AT, Bönnemann CG, Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells Cell reports30:932-946.e7 2019
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Bertero A, Fields PA, Ramani V, Bonora G, Yardimci GG, Reinecke H, Pabon L, Noble WS, Shendure J, Murry CE, Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory Nature communications10:1538 2018
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Gong S, Li Y, Su W, Ding Y, Lu J, Dong K, Hood S, Zhang W, Terstappen GC, Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells SLAS discovery : advancing life sciences R & D10:2472555218761355 2018
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Hoang P, Wang J, Conklin BR, Healy KE, Ma Z, Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells Nature protocols13:723-737 2018
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Li Y, Sun X, Liu H, Huang L, Meng G, Ding Y, Su W, Lu J, Gong S, Terstappen GC, Zhang R, Zhang W, Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs Neuroscience bulletin35:996-1010 2018
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Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H, TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes Nature communications10:4671 2018
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Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium mTeSR1
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Substrate Matrigel
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