Description:
APPARENTLY HEALTHY INDIVIDUAL
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Apparently Healthy Collection |
| Alternate IDs |
GM17211 [APPARENTLY HEALTHY INDIVIDUAL] |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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DNA from LCL
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Race
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White
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Family Member
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1
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Relation to Proband
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proband
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Confirmation
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Karyotypic analysis and Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
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| IMMUNOGLOBULIN PRODUCTION |
Lymphoid Culture Secretes IgA2 (Lambda) |
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| Remarks |
HLA type A9,29,B12,Bw15; secretes IgA2 (Lambda); 46,XY; 8% of cells show random chromosome loss/gain; see GM09918 Fibro |
| Sotamaa K, Liyanarachchi S, Mecklin JP, Järvinen H, Aaltonen LA, Peltomäki P, de la Chapelle A, p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome Clinical cancer research : an official journal of the American Association for Cancer Research11:6840-4 2005 |
| PubMed ID: 16203772 |
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| Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Lepage P, Lavergne K, Villeneuve A, Gaudin T, Brandstrom H, Beck A, Verner A, Kingsley J, Harmsen E, Labuda D, Morgan K, Vohl MC, Naumova AK, Sinnett D, Hudson TJ, A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics16(2):184-93 2004 |
| PubMed ID: 14583597 |
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| Diaz-Sanchez D, Dotson AR, Takenaka H, Saxon A, Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest94:1417-25 1994 |
| PubMed ID: 7523450 |
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| Reardon JT, Thompson LH, Sancar A, Excision repair in man and the molecular basis of xeroderma pigmentosum syndrome. Cold Spring Harb Symp Quant Biol58:605-17 1993 |
| PubMed ID: 7956075 |
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| Takai S, Price FM, Sanford KK, Tarone RE, Parshad R, Persistence of chromatid damage after G2 phase X-irradiation in lymphoblastoid cells from Gardner's syndrome. Carcinogenesis11:1425-8 1990 |
| PubMed ID: 2387030 |
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| Moore JS, Prystowsky MB, Hoover RG, Besa EC, Nowell PC, Defective T cell-mediated, isotype-specific immunoglobulin regulation in B cell chronic lymphocytic leukemia. Blood71:1012-20 1988 |
| PubMed ID: 2895674 |
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| Yemul S, Berger C, Estabrook A, Suarez S, Edelson R, Bayley H, Selective killing of T lymphocytes by phototoxic liposomes. Proc Natl Acad Sci U S A84:246-50 1987 |
| PubMed ID: 3491992 |
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| Haluska FG, Finver S, Tsujimoto Y, Croce CM, The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining. Nature324:158-61 1986 |
| PubMed ID: 3097550 |
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| Mixter PF, Wu SV, Studnicka GM, Robinson RR, A simple, computer-assisted assay to detect isotype-specific regulation of human immunoglobulin synthesis. J Immunol Methods91:195-203 1986 |
| PubMed ID: 3755453 |
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| Sun LK, Showe LC, Croce CM, Analysis of the 3' flanking region of the human c-myc gene in lymphomas with the t(8;22) and t(2;8) chromosomal translocations. Nucleic Acids Res14:4037-50 1986 |
| PubMed ID: 3714470 |
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| Isobe M, Erikson J, Emanuel BS, Nowell PC, Croce CM, Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells. Science228:580-2 1985 |
| PubMed ID: 3983641 |
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| Max EE, Korsmeyer SJ, Human J chain gene. Structure and expression in B lymphoid cells. J Exp Med161:832-49 1985 |
| PubMed ID: 2984306 |
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| Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce CM, Differential expression of the normal and of the translocated human c- myc oncogenes in B cells. Proc Natl Acad Sci U S A80:4822-6 1983 |
| PubMed ID: 6308654 |
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| Erikson J, Martinis J, Croce CM, Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature294:173-175 1981 |
| PubMed ID: 6795508 |
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| Dolby TW, Devuono J, Croce CM, Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. Proc Natl Acad Sci U S A77:6027-31 1980 |
| PubMed ID: 6777778 |
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| McGarrity GJ, Phillips DM, Vaidya AB, Mycoplasmal infection of lymphocyte cell cultures: infection with M. salivarium. In Vitro16:346-56 1980 |
| PubMed ID: 7399547 |
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| Croce CM, Shander M, Martinis J, Cicurel L, D'Ancona GG, Dolby TW, Koprowski H, Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A76:3416-9 1979 |
| PubMed ID: 114999 |
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| Moses RE, Beaudet AL, Apurinic DNA endonuclease activities in repair-deficient human cell lines. Nucleic Acids Res5:463-73 1978 |
| PubMed ID: 634794 |
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