Description:
APPARENTLY HEALTHY INDIVIDUAL
|
Repository
|
NIGMS Human Genetic Cell Repository
|
| Subcollection |
Apparently Healthy Collection |
| Alternate IDs |
GM18005 [APPARENTLY HEALTHY INDIVIDUAL] |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
|
Biopsy Source
|
Peripheral vein
|
|
Cell Type
|
B-Lymphocyte
|
|
Tissue Type
|
Blood
|
|
Transformant
|
Epstein-Barr Virus
|
|
Sample Source
|
DNA from LCL
|
|
Race
|
White
|
|
Family Member
|
1
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Karyotypic analysis and Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
| |
| Remarks |
Formerly GM01076; 46,XY; 4% of cells showed a random chromosome loss |
| Kennedy DO, Agrawal M, Shen J, Terry MB, Zhang FF, Senie RT, Motykiewicz G, Santella RM, DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer Journal of the National Cancer Institute97:127-32 2005 |
| PubMed ID: 15657342 |
| |
| Sotamaa K, Liyanarachchi S, Mecklin JP, Järvinen H, Aaltonen LA, Peltomäki P, de la Chapelle A, p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome Clinical cancer research : an official journal of the American Association for Cancer Research11:6840-4 2005 |
| PubMed ID: 16203772 |
| |
| Kumaresan KR, Lambert MW, Fanconi anemia, complementation group A, cells are defective in ability to
produce incisions at sites of psoralen interstrand cross-links. Carcinogenesis21(4):741-51 2000 |
| PubMed ID: 10753211 |
| |
| McMahon LW, Walsh CE, Lambert MW, Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J Biol Chem274:32904-8 1999 |
| PubMed ID: 10551855 |
| |
| Feng S, Parrish DD, Lambert MW, A processive versus a distributive mechanism of action correlates with
differences in ability of normal and xeroderma pigmentosum group A endonucleases
to incise damaged nucleosomal DNA. Carcinogenesis18(2):279-86 1997 |
| PubMed ID: 9054619 |
| |
| Kumaresan KR, Hang B, Lambert MW, Human endonucleolytic incision of DNA 3' and 5' to a site-directed psoralen monoadduct and interstrand cross-link. J Biol Chem270:30709-16 1995 |
| PubMed ID: 8530510 |
| |
| Parrish DD, Lambert MW, Chromatin-associated DNA endonucleases from xeroderma pigmentosum cells are defective in interaction with damaged nucleosomal DNA. Mutat Res235:65-80 1990 |
| PubMed ID: 2308593 |
| |
| Tsongalis GJ, Lambert WC, Lambert MW, Electroporation of normal human DNA endonucleases into xeroderma pigmentosum cells corrects their DNA repair defect. Carcinogenesis11:499-503 1990 |
| PubMed ID: 2311196 |
| |
| Tsongalis GJ, Lambert WC, Lambert MW, Correction of the ultraviolet light induced DNA-repair defect in xeroderma pigmentosum cells by electroporation of a normal human endonuclease [published erratum appears in Mutat Res 1990 Oct;245(2):135] Mutat Res244:257-63 1990 |
| PubMed ID: 2366820 |
| |
| Yu WD, Wenger SL, Steele MW, X chromosome imprinting in fragile X syndrome. Hum Genet85:590-4 1990 |
| PubMed ID: 2227950 |
| |
| Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, Nedwin JJ, Barnett TR, Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11. Proc Natl Acad Sci U S A84:5350-4 1987 |
| PubMed ID: 2955415 |
| |
| Lambert WC, Lambert MW, Increased sensitivity of a xeroderma pigmentosum lymphoblastoid cell line to serum deprivation in vitro. In Vitro19:621-4 1983 |
| PubMed ID: 6885101 |
| |
| Lee DE, Okorodudu AO, Lambert WC, Lambert MW, Defective DNA endonuclease activity on anthramycin treated DNA in xeroderma pigmentosum and mouse melanoma cells. Biochem Biophys Res Commun107:395-402 1982 |
| PubMed ID: 6215036 |
| |
| Okorodudu AO, Lambert WC, Lambert MW, Nuclear deoxyribonuclease activities in normal and xeroderma pigmentosum lymphoblastoid cells. Biochem Biophys Res Commun108:576-84 1982 |
| PubMed ID: 6216888 |
| |
| Okorodudu, Differences in nuclear deoxyribonuclease activities in normal and xeroderma pigmentosum lymphoblasts. J Cell Biol91:63a (1981):576-84 1981 |
| PubMed ID: 6216888 |
|
|