Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Old Order Amish Major Affective Disorder
Heritable Diseases |
| Class |
Disorders of the Nervous System |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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DNA from LCL
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Race
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White
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Ethnicity
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AMISH
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Family Member
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35
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
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| Remarks |
Clinically affected; type I bipolar disorder (BPI); onset with depression at age 30 and mania by 31; multiple hospitalizations at two year intervals; psychotic; medication change and compliance have resulted in recent years of wellness; multiple siblings and relatives have a bipolar disorder; son of GM05993 and GM05995; see GM05990 Fibroblast |
| Vincent JB, Neves-Pereira ML, Paterson AD, Yamamoto E, Parikh SV, Macciardi
F, Gurling HM, Potkin SG, Pato CN, Macedo A, Kovacs M, Davies M, Lieberman JA,
Meltzer HY, Petronis A, Kennedy JL, An unstable trinucleotide-repeat region on chromosome 13 implicated in
spinocerebellar ataxia: a common expansion locus. Am J Hum Genet66(3):819-29 2000 |
| PubMed ID: 10712198 |
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| Bowman ED, Bromeke B, Lensing W, Shields PG, Apolipoprotein E allelic frequency in elderly smokers. Am J Med Genet76(1):32-6 1998 |
| PubMed ID: 9508061 |
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| Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Conte G, et al, Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish [see comments] Nature342:238-43 1989 |
| PubMed ID: 2682265 |
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| Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE, Bipolar affective disorders linked to DNA markers on chromosome 11. Nature325:783-7 1987 |
| PubMed ID: 2881209 |
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| Gerhard DS, Kidd KK, Kidd JR, Egeland JA, Housman DE, Identification of a recent recombination event within the human beta- globin gene cluster. Proc Natl Acad Sci U S A81:7875-9 1984 |
| PubMed ID: 6096866 |
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