Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Old Order Amish Major Affective Disorder
Heritable Diseases |
| Class |
Disorders of the Nervous System |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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DNA from LCL
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Race
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White
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Ethnicity
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AMISH
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Family Member
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3
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Confirmation
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Clinical summary/Case history
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ISCN
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46,XX
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
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| Remarks |
Clinically affected; recurrent major depressive disorder (MDDR); father, half-sister, paternal grandfather, and paternal uncle had type I bipolar disorder (BPI); deceased brother had major depression; onset at age 37; psychotic; multiple hospital admissions; 46,XX; sister of GM07775; half-sister of GM07849 |
| Ginns EI, Ott J, Egeland JA, Allen CR, Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Falls KM, Keith TP, Paul SM, A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet12:431-5 1996 |
| PubMed ID: 8630500 |
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| Pauls DL, Gerhard DS, Lacy LG, Hostetter AM, Allen CR, Bland SD, LaBuda MC, Egeland JA, Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110. Genomics11:730-6 1991 |
| PubMed ID: 1774072 |
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