Description:
BREAST CANCER 2, EARLY-ONSET; BRCA2
BREAST CANCER INFORMATION CORE (BIC) BRCA1/BRCA2 MUTATION PANEL DNA SAMPLES
Repository
|
No Data
|
Subcollection |
Heritable Diseases Hereditary Cancers |
Class |
Heritable Cancer Syndromes and other Cancers |
Sample Source
|
No Data
|
Subject Type
|
No Data
|
Family Type
|
No Data
|
Ethnicity
|
No Data
|
Family Member
|
No Data
|
Genetic Data
|
No Data
|
IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
|
Gene |
BRCA2 |
Chromosomal Location |
13q13.1 |
Allelic Variant 1 |
; BREAST CANCER 2, EARLY-ONSET |
Identified Mutation |
6426delTT |
Atkins A, Gupta P, Zhang BM, Tsai WS, Lucas J, Javey M, Vora A, Mei R, Detection of Circulating Tumor DNA with a Single-Molecule Sequencing Analysis Validated for Targeted and Immunotherapy Selection Molecular diagnosis & therapy: 2019 |
PubMed ID: 31209714 |
|
Schubert EL, Lee MK, Mefford HC, Argonza RH, Morrow JE, Hull J, Dann JL, King MC, BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2 [see comments] Am J Hum Genet60:1031-40 1997 |
PubMed ID: 9150150 |
Split Ratio |
1:3 |
Temperature |
37 C |
Percent CO2 |
5% |
Percent O2 |
AMBIENT |
Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
Serum |
15% fetal bovine serum Not Inactivated |
Substrate |
None specified |
Subcultivation Method |
dilution - add fresh medium |
Supplement |
- |
|
|