Description:
TRANSLOCATED CHROMOSOME
MAJOR AFFECTIVE DISORDER - 125480 OR 309200
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Chromosome Abnormalities
Heritable Diseases
dbGaP |
| Class |
Disorders of the Nervous System |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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DNA from LCL
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Family Member
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1
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Relation to Proband
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proband
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Confirmation
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Karyotypic analysis after cell line submission to CCR
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ISCN
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46,XX,t(14;18)(14pter>14q21::18q22.1>18qter;18pter>18q22.1::14q21>14qter)
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase,Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
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| Cytogenetics |
Chromosome 14: DERIVATIVE CHROMOSOME Breakpoint 14q21 t(14;18)14q21 |
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Chromosome 14: TRANSLOCATION Breakpoint 14q21 |
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Chromosome 14: TRANSLOCATION Breakpoint 14q21 t(14;18)14q21 |
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Chromosome 18: DERIVATIVE CHROMOSOME Breakpoint 18q22 t(14;18)18q22 |
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Chromosome 18: TRANSLOCATION Breakpoint 18q22 |
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Chromosome 18: TRANSLOCATION Breakpoint 18q22 t(14;18)18q22 |
| Remarks |
Line JL481; bipolar; no family history of affective disorder; first depressive syptoms at age 13; two episodes of hypomania; paranoid tendencies; panic attacks; no hospitalizations; parental line of hybrid GM16466 |
| Tang Z, Berlin DS, Toji L, Toruner GA, Beiswanger C, Kulkarni S, Martin CL, Emanuel BS, Christman M, Gerry NP, A dynamic database of microarray-characterized cell lines with various cytogenetic and genomic backgrounds G3 (Bethesda, Md)3:1143-9 2013 |
| PubMed ID: 23665875 |
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| Overhauser J, Berrettini WH, Rojas K, Affective disorder associated with a balanced translocation involving chromosome 14 and 18. Psychiatr Genet8(2):53-6 1998 |
| PubMed ID: 9686423 |
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