ND02961
LCL from B-Lymphocyte
Description:
POPULATION/CONVENIENCE CONTROL
DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
|
Repository
|
NINDS Repository
|
| Subcollection |
Control
Parkinsonism |
|
Biopsy Source
|
Peripheral vein
|
|
Cell Type
|
B-Lymphocyte
|
|
Tissue Type
|
Blood
|
|
Transformant
|
Epstein-Barr Virus
|
|
Sample Source
|
LCL from B-Lymphocyte
|
|
Race
|
White
|
|
Subject Type
|
case-spouse
|
|
Family Type
|
NUCLEAR FAMILIES - ONE AFFECTED
|
|
Ethnicity
|
Not Hispanic/Latino
|
|
Country of Origin
|
USA
|
|
Family Member
|
2
|
|
Family History
|
N
|
|
Relation to Proband
|
spouse
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
| Gene |
LRRK2 |
| Chromosomal Location |
12q12 |
| Allelic Variant 1 |
; WILDTYPE |
| Identified Mutation |
WILDTYPE for GLY2019 |
| |
| Gene |
LRRK2 |
| Chromosomal Location |
12q12 |
| Allelic Variant 2 |
; WILDTYPE |
| Identified Mutation |
WILDTYPE for GLY2019 |
| Ferrari R, Mok K, Moreno JH, Cosentino S, Goldman J, Pietrini P, Mayeux R, Tierney MC, Kapogiannis D, Jicha GA, Murrell JR, Ghetti B, Wassermann EM, Grafman J, Hardy J, Huey ED, Momeni P, Screening for C9ORF72 repeat expansion in FTLD Neurobiology of aging33:1850.e1-11 2012 |
| PubMed ID: 22459598 |
| |
| Ferrari R, Moreno JH, Minhajuddin AT, O'Bryant SE, Reisch JS, Barber RC, Momeni P, Implication of common and disease specific variants in CLU, CR1, and PICALM Neurobiology of aging33:1846.e7-18 2011 |
| PubMed ID: 22402018 |
| |
| Li Y, Rowland C, Schrodi S, Laird W, Tacey K, Ross D, Leong D, Catanese J, Sninsky J, Grupe A, A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan American journal of human genetics78:1090-2; author reply 1092-4 2006 |
| PubMed ID: 16685663 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not Inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
|
|