Finnish in Finland [FIN]

The biomaterials currently available for this population are shown in the table below:

Population Finnish in Finland [FIN]
DNA Sample Panel MGP00001
Individual DNA Samples 103
Individual Cell Cultures 103

Principal Investigator:
Leena Peltonen, Wellcome Trust Sanger Institute, Hinxton, UK and University of Helsinki, Helsinki, Finland

Population Description

These cell lines and DNA samples were prepared from blood samples collected from unrelated individuals from Finland. All individuals identified themselves as having at least three out of four grandparents who were born in Finland, and 98% of individuals participating have all four grandparents born in Finland. The participants include some individuals with grandparents born in Finnish Karelia, a part of Finland until 1947, who also represent the Finnish population.

The complete descriptor "Finnish in Finland" should be used the first time these samples are referred to in an article or presentation. After the complete descriptor has been provided, it is acceptable to use the shorthand label "Finnish" or the abbreviation "FIN" in the remainder of the article or presentation.

It may be scientifically appropriate to pool data from these samples with data from other ancestrally related groups, when the data show that the groups have similar allele frequencies. If the groups all have European ancestry, the designation "European ancestry" (EUA) to describe the combined analysis panel is recommended. If only groups very closely related to the Finnish have similar allele frequencies, then another abbreviation may need to be used. Additional guidance about how to refer to the populations can be found at Guidelines for Referring to the Populations in Publications and Presentations.

Policies and Guidelines


References

1. Jakkula E, Rehnstrom K, Varilo T et al. (2008) The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet 83(6): 787-794.

2. Kittles RA, Bergen AW, Urbanek M et al. (1999) Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck. Am J Phys Anthropol 108(4): 381-399.

3. Norio R (2003a) Finnish Disease Heritage I: characteristics, causes, background. Hum Genet 112(5-6): 441-456.

4. Norio R (2003b) The Finnish Disease Heritage III: the individual diseases. Hum Genet 112(5-6): 470-526.

5. Norio R (2003c) Finnish Disease Heritage II: population prehistory and genetic roots of Finns. Hum Genet 112(5-6): 457-469.

6. Pastinen T, Perola M, Ignatius J et al. (2001) Dissecting a population genome for targeted screening of disease mutations. Hum Mol Genet 10(26): 2961-2972.

7. Peltonen L, Jalanko A, Varilo T (1999) Molecular genetics of the Finnish disease heritage. Hum Mol Genet 8(10): 1913-1923.

8. Service S, Deyoung J, Karayiorgou M et al. (2006) Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet 38(5): 556-560.