Cytogenomics

In-Depth DNA Discovery

The Coriell Institute Cytogenetics Laboratory is a state-of- the-art facility performing conventional and molecular cytogenetic analyses on various cell types from diverse species (human, mouse, rat, chimpanzee, canine, etc). The laboratory is equipped with a network of CytoVisionTM Image Analysis and Capturing Systems used to perform G-banded karyotyping and fluorescent in situ hybridization (FISH).

Detailed analyses of genome-wide unbalanced chromosomal aberrations, such as copy number variations (CNVs) and loss of heterozygosity (LOH) or long contiguous stretches of homozygosity (LCSHs), are performed using the Affymetrix Genome-Wide Human SNP Array 6.0, in collaboration with Coriell’s Genotyping and Microarray Center.

Key Cytogenomic Services at Coriell

  • G-banded karyotype analysis
  • FISH analysis including probe design and validation
  • Affymetrix Genome-Wide Human SNP Array 6.0
  • Application of cytogenetic/cytogenomic services for stem cell studies and transgenics quality control
  • Protocol Design: optimization to ensure each custom service is performed to highest research standards