| Gene | Description | Location | Gene Omim Number | Disease Omim Number |
| DBT | DIHYDROLIPOAMIDE BRANCHED-CHAIN TRANSACYLASE; DBT | 1p31 | 248610 | 248610 |
| DCP1A | DECAPPING mRNA 1A; DCP1A | 3p21.1 | 607010 | 607010 |
| DDB2 | DNA DAMAGE-BINDING PROTEIN 2; DDB2 | 11p12-p11 | 600811 | 600811 |
| DDX3X | DEAD-BOX HELICASE 3, X-LINKED; DDX3X | Xp11.4 | 300160 | 300160 |
| DHCR7 | 7-DEHYDROCHOLESTEROL REDUCTASE; DHCR7 | 11q12-q13 | 602858 | 602858 |
| DKC1 | DYSKERIN; DKC1 | Xq28 | 300126 | 300126 |
| DMD | DYSTROPHIN; DMD | Xp21.2 | 300377 | 300377 |
| DMPK | DYSTROPHIA MYOTONICA PROTEIN KINASE; DMPK | 19q13.2-q13.3 | 605377 | 605377 |
| DNMT3B | DNA METHYLTRANSFERASE 3B; DNMT3B | 20q11.2 | 602900 | 602900 |
| DPAGT1 | DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINE PHOSPHOTRANSFERASE; DPAGT1 | 11q23.3 | 191350 | 191350 |
| DPM1 | DOLICHYL-PHOSPHATE MANNOSYLTRANSFERASE 1, CATALYTIC SUBUNIT; DPM1 | 20q13.13 | 603503 | 603503 |
| DRPLA | ATROPHIN 1; ATN1 | 1213.31 | 607462 | 125370 |
| DSP | DESMOPLAKIN; DSP | 6p24.3 | 125647 | 125647 |
| DYM | DYMECLIN; DYM | 18q12-q21.1 | 607461 | 607461 |
| Dynamin 2 | DYNAMIN 2; DNM2 | 19p13.2 | 602378 | 602378 |