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Induced Pluripotent Stem Cells
To facilitate research on differentiated cell types and other biomedical investigations, the NIGMS Repository offers human induced pluripotent stem cell (hiPSC) lines derived from apparently healthy individuals or from individuals affected with heritable diseases. These hiPSCs were created using a variety of reprogramming techniques*.
Some of the available hiPSC lines were derived from externally submitted iPSC lines, where a distribution stock was made. Others were derived from established LCLs or Fibroblast lines available in the catalog. In addition to QC tests (viability, contamination, karyotyping, microarray genotyping, and microsatellite matches with the parent cell culture), extensive pluripotency characterizations are performed on each NIGMS Repository hiPSC line. Pluripotency characterizations include the following assays:
Surface antigen expression
Embryoid body formation
PluriTest gene expression assay
A complete Certificate of Analysis (CofA) that includes images and quantitative test results is available for each hiPSC line. The CofA PDF specifies which pluripotency characterizations were performed on each hiPSC line.
The Protocol PDFs outline the proper steps for successful handling of the hiPSCs. Additional information is also found on the CofA PDF, including necessary media components, substrates, passage methods, and split ratios.
* For commercial purposes, please note that Limited Use Label Licenses (LULLs) may apply.
Apparently Healthy hiPSC Lines
Records Return:
(15)
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500
Catalog ID
Description
Parent Line
Transformant
LULL
Gender
Age
Race
Biopsy Source
Affected Status
Related Samples
Certificate of Analysis
Protocol
GM23392
APPARENTLY HEALTHY FETAL TISSUE
GM06114
Reprogrammed (Retroviral)
WARF
Male
20 FW
Black/African American
Lung
No
910
CofA PDF
Protocol PDF
GM23396
APPARENTLY HEALTHY FETAL TISSUE
GM06111
Reprogrammed (Retroviral)
WARF
Female
16 FW
Black/African American
Skin
No
911
CofA PDF
Protocol PDF
GM23413
APPARENTLY HEALTHY FETAL TISSUE
GM06112
Reprogrammed (Retroviral)
WARF
Female
16 FW
Black/African American
Lung
No
911
CofA PDF
Protocol PDF
GM23450
APPARENTLY HEALTHY FETAL TISSUE
GM06113
Reprogrammed (Retroviral)
WARF
Male
20 FW
Black/African American
Skin
No
910
CofA PDF
Protocol PDF
GM23716
APPARENTLY HEALTHY FETAL TISSUE
GM06111
Reprogrammed (Episomal)
WARF
Female
16 FW
Black/African American
Skin
No
911
CofA PDF
Protocol PDF
GM23279
APPARENTLY HEALTHY INDIVIDUAL
Not in Repository
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Female
36 YR
White
Skin
No
2997
CofA PDF
Protocol PDF
GM23476
APPARENTLY HEALTHY INDIVIDUAL
GM04506
Reprogrammed (Lentiviral)
WARF
Female
20 YR
White
Skin
No
732
CofA PDF
Protocol PDF
GM23720
APPARENTLY HEALTHY INDIVIDUAL
GM02254
Reprogrammed (Episomal)
WARF
Female
22 YR
White
Peripheral vein
No
3045
CofA PDF
Protocol PDF
GM25256
APPARENTLY HEALTHY INDIVIDUAL
WTC11 (6W JY)
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
30 YR
Asian
Skin
No
3181
CofA PDF
Protocol PDF
GM25430
APPARENTLY HEALTHY INDIVIDUAL
CV-B
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Male
62 YR
White
Arm
No
3238
CofA PDF
Protocol PDF
GM23338
PERSONAL GENOME PROJECT
GM23248
Reprogrammed (Retroviral)
IP ACADEMIA JAPAN
Male
55 YR
White
Skin
No
2980
CofA PDF
Protocol PDF
GM26077
PERSONAL GENOME PROJECT
GM24143
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Female
74 YR
White
Unknown
3140
CofA PDF
Protocol PDF
GM26105
PERSONAL GENOME PROJECT
GM24385
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
45 YR
White
Unknown
3140
CofA PDF
Protocol PDF
GM26107
PERSONAL GENOME PROJECT
GM24631
Reprogrammed (Episomal)
IP ACADEMIA JAPAN
Male
33 YR
Asian, Other
Unknown
3150
CofA PDF
Protocol PDF
GM27730
PERSONAL GENOME PROJECT
GM27908
Reprogrammed (Sendai)
Sendai-Cyto Tune
Male
45 YR
White
Unknown
3140
CofA PDF
Protocol PDF
Disease-Specific hiPSC Lines
Records Return:
(65)
Show
>
5
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100
200
500
1
2
3
4
Catalog ID
Diagnosis
Parent Line
Transformant
Gender
LULL
Age
Race
Biopsy Source
Affected Status
Gene(s)
Mutation(s)
Family and Associated Specimens
Certificate of Analysis
Protocol
GM24666
ALZHEIMER DISEASE; AD
SAD 2.2
Reprogrammed (Retroviral)
Male
IP ACADEMIA JAPAN
83 YR
White
Skin
Yes
3234
CofA PDF
Protocol PDF
GM24675
ALZHEIMER DISEASE; AD
APP 2.3
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
60 YR
Skin
Yes
3236
CofA PDF
Protocol PDF
GM27717
APPARENTLY HEALTHY INDIVIDUAL
GM03524
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
67 YR
Black/African American
No
CofA PDF
Protocol PDF
GM27857
CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1
GM27448
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
4 YR
Asian
Yes
SLC6A8
DEL EX10-11
3486
CofA PDF
Protocol PDF
GM27177
CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2
GM20385
Reprogrammed (Episomal)
Female
IP ACADEMIA JAPAN
11 YR
Yes
CLN2 CLN2
IVS5AS, G>C, -1
IVS5-1G>A
3406
CofA PDF
Protocol PDF
GM26650
CHOROIDEREMIA; CHM
GM25393
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
57 YR
White
Skin
Yes
CHM CHM
c.189+1G>T
ALA117ALA
3214
CofA PDF
Protocol PDF
GM26663
CHOROIDEREMIA; CHM
GM25383
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
20 YR
White
Skin
Yes
CHM CHM CHM
ARG270TER
c.116+215insCCTTT
c.116+80C>T
3210
CofA PDF
Protocol PDF
GM27381
CONGENITAL DISORDER OF DEGLYCOSYLATION; CDDG
GM25344
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
10 YR
White
Yes
NGLY1 NGLY1 CACNA1S
GLN208TER
GLY310GLY
THR1354SER
3196
CofA PDF
Protocol PDF
GM24683
CYSTIC FIBROSIS; CF
GM01014
Reprogrammed (Episomal)
Male
IP ACADEMIA JAPAN
13 YR
White
Skin
Yes
CFTR CFTR
PHE508DEL
PHE508DEL
93
CofA PDF
Protocol PDF
GM23226
DIABETES MELLITUS, JUVENILE-ONSET INSULIN-DEPENDENT; IDDM
GM02416
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
42 YR
American Indian/Alaska Native
Skin
Yes
383
CofA PDF
Protocol PDF
GM24559
DYSTROPHIA MYOTONICA 1; DM1
GM04602
Reprogrammed (Episomal)
Female
IP ACADEMIA JAPAN
2 YR
White
Skin
Yes
583
CofA PDF
Protocol PDF
GM26017
EPIDERMOLYSIS BULLOSA: DYSTROPHIC, JUNCTIONAL, OR SIMPLEX TYPES
GM10269
Reprogrammed (Sendai)
Male
Sendai-Cyto Tune
4 YR
White
Yes
1186
CofA PDF
Protocol PDF
GM27327
FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1; FSHD1
GM16277
Reprogrammed (Episomal)
Female
IP ACADEMIA JAPAN
77 YR
Peripheral vein
Yes
1939
CofA PDF
Protocol PDF
GM23404
FRIEDREICH ATAXIA 1; FRDA
GM03816
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
36 YR
White
Skin
Yes
FXN FXN
(GAA)n EXPANSION
(GAA)n EXPANSION
594
CofA PDF
Protocol PDF
GM23913
FRIEDREICH ATAXIA 1; FRDA
GM04078
Reprogrammed (Retroviral)
Male
IP ACADEMIA JAPAN
30 YR
White
Skin
Yes
FXN FXN
(GAA)n EXPANSION
(GAA)n EXPANSION
594
CofA PDF
Protocol PDF
GM27896
GLUT1 DEFICIENCY SYNDROME 1; GLUT1DS1
GM27897
Reprogrammed (mRNA)
Female
IP ACADEMIA JAPAN
19 YR
White
Skin
Yes
SLC2A1
c. 1454 C>T (p.Pro485Leu)
3500
CofA PDF
Protocol PDF
GM23225
HUNTINGTON DISEASE; HD
GM04281
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
20 YR
White
Skin
Yes
HD
(CAG)n EXPANSION
690
CofA PDF
Protocol PDF
GM26656
HURLER SYNDROME
GM00798
Reprogrammed (Sendai)
Female
Sendai-Cyto Tune
1 YR
White
Skin
Yes
IDUA IDUA
TRP402TER
TRP402TER
41
CofA PDF
Protocol PDF
GM27102
ISOGENIC CONTROL
GM24683
Reprogrammed (Episomal)
Male
IP ACADEMIA JAPAN
13 YR
White
Skin
Yes
93
CofA PDF
Protocol PDF
GM27173
ISOGENIC CONTROL
GM25305
Reprogrammed (Retroviral)
Female
IP ACADEMIA JAPAN
48 YR
Asian
Skin
Yes
3183
CofA PDF
Protocol PDF