GM03348
Fibroblast from Skin, Inguinal area
Description:
APPARENTLY HEALTHY INDIVIDUAL
|
Repository
|
NIGMS Human Genetic Cell Repository
|
| Subcollection |
Apparently Healthy Collection |
|
Biopsy Source
|
Inguinal area
|
|
Cell Type
|
Fibroblast
|
|
Tissue Type
|
Skin
|
|
Transformant
|
Untransformed
|
|
Sample Source
|
Fibroblast from Skin, Inguinal area
|
|
Race
|
White
|
|
Country of Origin
|
USA
|
|
Family Member
|
1
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Karyotypic analysis and Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| PDL at Freeze |
6.34 |
| Passage Frozen |
5 |
| |
| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
| |
| Remarks |
Skin biopsy (inguinal); 46,XY |
| Selgrade DF, Fullenkamp DE, Chychula IA, Li B, Dellefave-Castillo L, Dubash AD, Ohiri J, Monroe TO, Blancard M, Tomar G, Holgren C, Burridge PW, George AL, Demonbreun AR, Puckelwartz M, George SA, Efimov IR, Green KJ, McNally EM, Susceptibility to innate immune activation in genetically-mediated myocarditis The Journal of clinical investigation: 2024 |
| PubMed ID: 38768074 |
| |
| Zhang E, Neugebauer ME, Krasnow NA, Liu DR, Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference Nature communications15:1697 2023 |
| PubMed ID: 38402281 |
| |
| Cotticelli MG, Xia S, Truitt R, Doliba NM, Rozo AV, Tobias JW, Lee T, Chen J, Napierala JS, Napierala M, Yang W, Wilson RB, Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response Disease models & mechanisms16:1697 2022 |
| PubMed ID: 36107856 |
| |
| Monternier PA, Singh J, Parasar P, Theurey P, DeWitt S, Jacques V, Klett E, Kaur N, Nagaraja TN, Moller DE, Hallakou-Bozec S, Therapeutic potential of deuterium-stabilized (R)-pioglitazone-PXL065-for X-linked adrenoleukodystrophy Journal of inherited metabolic disease16:1697 2022 |
| PubMed ID: 35510808 |
| |
| Napierala JS, Rajapakshe K, Clark A, Chen YY, Huang S, Mesaros C, Xu P, Blair IA, Hauser LA, Farmer J, Lynch DR, Edwards DP, Coarfa C, Napierala M, Reverse phase protein array reveals correlation of retinoic acid metabolism with cardiomyopathy in Friedreich's ataxia Molecular & cellular proteomics : MCP16:100094 2021 |
| PubMed ID: 33991687 |
| |
| Vaz S, Ferreira FJ, Macedo JC, Leor G, Ben-David U, Bessa J, Logarinho E, FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation Cell death & disease12:542 2021 |
| PubMed ID: 34035233 |
| |
| Wang D, Ho ES, Cotticelli MG, Xu P, Napierala JS, Hauser LA, Napierala M, Himes BE, Wilson RB, Lynch DR, Mesaros C, Skin fibroblast metabolomic profiling reveals that lipid dysfunction predicts the severity of Friedreich's ataxia Journal of lipid research63:100255 2021 |
| PubMed ID: 35850241 |
| |
| Aghaei-Ghareh-Bolagh B, Mukherjee S, Lockley KM, Mithieux SM, Wang Z, Emmerson S, Darzi S, Gargett CE, Weiss AS, A novel tropoelastin-based resorbable surgical mesh for pelvic organ prolapse repair Materials today Bio8:100081 2020 |
| PubMed ID: 33210083 |
| |
| Gao D, Morini E, Salani M, Krauson AJ, Chekuri A, Sharma N, Ragavendran A, Erdin S, Logan EM, Li W, Dakka A, Narasimhan J, Zhao X, Naryshkin N, Trotta CR, Effenberger KA, Woll MG, Gabbeta V, Karp G, Yu Y, Johnson G, Paquette WD, Cutting GR, Talkowski ME, Slaugenhaupt SA, A deep learning approach to identify gene targets of a therapeutic for human splicing disorders Nature communications12:3332 2020 |
| PubMed ID: 34099697 |
| |
| Aghaei-Ghareh-Bolagh B, Mithieux SM, Hiob MA, Wang Y, Chong A, Weiss AS, Fabricated tropoelastin-silk yarns and woven textiles for diverse tissue engineering applications Acta biomaterialia91:112-122 2019 |
| PubMed ID: 31004842 |
| |
| Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A, Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model Free radical biology & medicine137:46-58 2019 |
| PubMed ID: 31004752 |
| |
| Tambe MA, Ng BG, Freeze HH, N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity Cell reports29:4620-4631.e4 2019 |
| PubMed ID: 31875565 |
| |
| Front S, Almeida S, Zoete V, Charollais-Thoenig J, Gallienne E, Marmy C, Pilloud V, Marti R, Wood T, Martin OR, Demotz S, 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations Bioorganic and Medical Chemistry26:5462-5469 2018 |
| PubMed ID: 30270003 |
| |
| Ng BG, Lourenço CM, Losfeld ME, Buckingham KJ, Kircher M, Nickerson DA, Shendure J, Bamshad MJ, University of Washington Center for Mendelian Genomics MJ, Freeze HH, Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation Journal of inherited metabolic disease42:993-997 2018 |
| PubMed ID: 30945312 |
| |
| Gondcaille C, Genin EC, Lopez TE, Dias AM, Geillon F, Andreoletti P, Cherkaoui-Malki M, Nury T, Lizard G, Weinhofer I, Berger J, Kase ET, Trompier D, Savary S., LXR antagonists induce ABCD2 expression. Biochim Biophys Acta.pii:S1388-1981 2013 |
| PubMed ID: 24239766 |
| |
| Singh J, Khan M, Singh I, Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes Biochimica et biophysica actapii:S1388-1981 2012 |
| PubMed ID: 23318275 |
| |
| Bax DV, McKenzie DR, Bilek MM, Weiss AS, Directed cell attachment by tropoelastin on masked plasma immersion ion implantation treated PTFE Biomaterials32:6710-8 2011 |
| PubMed ID: 21669455 |
| |
| Bax DV, Tipa RS, Kondyurin A, Higgins MJ, Tsoutas K, Gelmi A, Wallace GG, McKenzie DR, Weiss AS, Bilek MM, Cell patterning via linker-free protein functionalization of an organic conducting polymer (polypyrrole) electrode Acta biomaterialia8:2538-48 2011 |
| PubMed ID: 22426287 |
| |
| Bax DV, Wang Y, Li Z, Maitz PK, McKenzie DR, Bilek MM, Weiss AS, Binding of the cell adhesive protein tropoelastin to PTFE through plasma immersion ion implantation treatment Biomaterials32:5100-11 2011 |
| PubMed ID: 21527206 |
| |
| ENCODE Project Consortium , Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J, Kaul R, Khatun J, Lajoie BR, Landt SG, Lee BK, Pauli F, Rosenbloom KR, Sabo P, Safi A, Sanyal A, Shoresh N, Simon JM, Song L, Trinklein ND, Altshuler RC, Birney E, Brown JB, Cheng C, Djebali S, Dong X, Dunham I, Ernst J, Furey TS, Gerstein M, Giardine B, Greven M, Hardison RC, Harris RS, Herrero J, Hoffman MM, Iyer S, Kelllis M, Khatun J, Kheradpour P, Kundaje A, Lassman T, Li Q, Lin X, Marinov GK, Merkel A, Mortazavi A, Parker SC, Reddy TE, Rozowsky J, Schlesinger F, Thurman RE, Wang J, Ward LD, Whitfield TW, Wilder SP, Wu W, Xi HS, Yip KY, Zhuang J, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M, Pazin MJ, Lowdon RF, Dillon LA, Adams LB, Kelly CJ, Zhang J, Wexler JR, Green ED, Good PJ, Feingold EA, Bernstein BE, Birney E, Crawford GE, Dekker J, Elinitski L, Farnham PJ, Gerstein M, Giddings MC, Gingeras TR, Green ED, Guigó R, Hardison RC, Hubbard TJ, Kellis M, Kent WJ, Lieb JD, Margulies EH, Myers RM, Snyder M, Starnatoyannopoulos JA, Tennebaum SA, Weng Z, White KP, Wold B, Khatun J, Yu Y, Wrobel J, Risk BA, Gunawardena HP, Kuiper HC, Maier CW, Xie L, Chen X, Giddings MC, Bernstein BE, Epstein CB, Shoresh N, Ernst J, Kheradpour P, Mikkelsen TS, Gillespie S, Goren A, Ram O, Zhang X, Wang L, Issner R, Coyne MJ, Durham T, Ku M, Truong T, Ward LD, Altshuler RC, Eaton ML, Kellis M, Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Batut P, Bell I, Bell K, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena HP, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Li G, Luo OJ, Park E, Preall JB, Presaud K, Ribeca P, Risk BA, Robyr D, Ruan X, Sammeth M, Sandu KS, Schaeffer L, See LH, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Hayashizaki Y, Harrow J, Gerstein M, Hubbard TJ, Reymond A, Antonarakis SE, Hannon GJ, Giddings MC, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras TR, Rosenbloom KR, Sloan CA, Learned K, Malladi VS, Wong MC, Barber GP, Cline MS, Dreszer TR, Heitner SG, Karolchik D, Kent WJ, Kirkup VM, Meyer LR, Long JC, Maddren M, Raney BJ, Furey TS, Song L, Grasfeder LL, Giresi PG, Lee BK, Battenhouse A, Sheffield NC, Simon JM, Showers KA, Safi A, London D, Bhinge AA, Shestak C, Schaner MR, Kim SK, Zhang ZZ, Mieczkowski PA, Mieczkowska JO, Liu Z, McDaniell RM, Ni Y, Rashid NU, Kim MJ, Adar S, Zhang Z, Wang T, Winter D, Keefe D, Birney E, Iyer VR, Lieb JD, Crawford GE, Li G, Sandhu KS, Zheng M, Wang P, Luo OJ, Shahab A, Fullwood MJ, Ruan X, Ruan Y, Myers RM, Pauli F, Williams BA, Gertz J, Marinov GK, Reddy TE, Vielmetter J, Partridge EC, Trout D, Varley KE, Gasper C, Bansal A, Pepke S, Jain P, Amrhein H, Bowling KM, Anaya M, Cross MK, King B, Muratet MA, Antoshechkin I, Newberry KM, McCue K, Nesmith AS, Fisher-Aylor KI, Pusey B, DeSalvo G, Parker SL, Balasubramanian S, Davis NS, Meadows SK, Eggleston T, Gunter C, Newberry JS, Levy SE, Absher DM, Mortazavi A, Wong WH, Wold B, Blow MJ, Visel A, Pennachio LA, Elnitski L, Margulies EH, Parker SC, Petrykowska HM, Abyzov A, Aken B, Barrell D, Barson G, Berry A, Bignell A, Boychenko V, Bussotti G, Chrast J, Davidson C, Derrien T, Despacio-Reyes G, Diekhans M, Ezkurdia I, Frankish A, Gilbert J, Gonzalez JM, Griffiths E, Harte R, Hendrix DA, Howald C, Hunt T, Jungreis I, Kay M, Khurana E, Kokocinski F, Leng J, Lin MF, Loveland J, Lu Z, Manthravadi D, Mariotti M, Mudge J, Mukherjee G, Notredame C, Pei B, Rodriguez JM, Saunders G, Sboner A, Searle S, Sisu C, Snow C, Steward C, Tanzer A, Tapanan E, Tress ML, van Baren MJ, Walters N, Washieti S, Wilming L, Zadissa A, Zhengdong Z, Brent M, Haussler D, Kellis M, Valencia A, Gerstein M, Raymond A, Guigó R, Harrow J, Hubbard TJ, Landt SG, Frietze S, Abyzov A, Addleman N, Alexander RP, Auerbach RK, Balasubramanian S, Bettinger K, Bhardwaj N, Boyle AP, Cao AR, Cayting P, Charos A, Cheng Y, Cheng C, Eastman C, Euskirchen G, Fleming JD, Grubert F, Habegger L, Hariharan M, Harmanci A, Iyenger S, Jin VX, Karczewski KJ, Kasowski M, Lacroute P, Lam H, Larnarre-Vincent N, Leng J, Lian J, Lindahl-Allen M, Min R, Miotto B, Monahan H, Moqtaderi Z, Mu XJ, O'Geen H, Ouyang Z, Patacsil D, Pei B, Raha D, Ramirez L, Reed B, Rozowsky J, Sboner A, Shi M, Sisu C, Slifer T, Witt H, Wu L, Xu X, Yan KK, Yang X, Yip KY, Zhang Z, Struhl K, Weissman SM, Gerstein M, Farnham PJ, Snyder M, Tenebaum SA, Penalva LO, Doyle F, Karmakar S, Landt SG, Bhanvadia RR, Choudhury A, Domanus M, Ma L, Moran J, Patacsil D, Slifer T, Victorsen A, Yang X, Snyder M, White KP, Auer T, Centarin L, Eichenlaub M, Gruhl F, Heerman S, Hoeckendorf B, Inoue D, Kellner T, Kirchmaier S, Mueller C, Reinhardt R, Schertel L, Schneider S, Sinn R, Wittbrodt B, Wittbrodt J, Weng Z, Whitfield TW, Wang J, Collins PJ, Aldred SF, Trinklein ND, Partridge EC, Myers RM, Dekker J, Jain G, Lajoie BR, Sanyal A, Balasundaram G, Bates DL, Byron R, Canfield TK, Diegel MJ, Dunn D, Ebersol AK, Ebersol AK, Frum T, Garg K, Gist E, Hansen RS, Boatman L, Haugen E, Humbert R, Jain G, Johnson AK, Johnson EM, Kutyavin TM, Lajoie BR, Lee K, Lotakis D, Maurano MT, Neph SJ, Neri FV, Nguyen ED, Qu H, Reynolds AP, Roach V, Rynes E, Sabo P, Sanchez ME, Sandstrom RS, Sanyal A, Shafer AO, Stergachis AB, Thomas S, Thurman RE, Vernot B, Vierstra J, Vong S, Wang H, Weaver MA, Yan Y, Zhang M, Akey JA, Bender M, Dorschner MO, Groudine M, MacCoss MJ, Navas P, Stamatoyannopoulos G, Kaul R, Dekker J, Stamatoyannopoulos JA, Dunham I, Beal K, Brazma A, Flicek P, Herrero J, Johnson N, Keefe D, Lukk M, Luscombe NM, Sobral D, Vaquerizas JM, Wilder SP, Batzoglou S, Sidow A, Hussami N, Kyriazopoulou-Panagiotopoulou S, Libbrecht MW, Schaub MA, Kundaje A, Hardison RC, Miller W, Giardine B, Harris RS, Wu W, Bickel PJ, Banfai B, Boley NP, Brown JB, Huang H, Li Q, Li JJ, Noble WS, Bilmes JA, Buske OJ, Hoffman MM, Sahu AO, Kharchenko PV, Park PJ, Baker D, Taylor J, Weng Z, Iyer S, Dong X, Greven M, Lin X, Wang J, Xi HS, Zhuang J, Gerstein M, Alexander RP, Balasubramanian S, Cheng C, Harmanci A, Lochovsky L, Min R, Mu XJ, Rozowsky J, Yan KK, Yip KY, Birney E, An integrated encyclopedia of DNA elements in the human genome Nature489:57-74 2011 |
| PubMed ID: 22955616 |
| |
| Jorge-Finnigan A, Gámez A, Pérez B, Ugarte M, Richard E, Different altered pattern expression of genes related to apoptosis in isolated methylmalonic aciduria cblB type and combined with homocystinuria cblC type Biochimica et biophysica acta1802:959-67 2010 |
| PubMed ID: 20696242 |
| |
| Annabi N, Mithieux SM, Weiss AS, Dehghani F, Cross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO2 Biomaterials31:1655-65 2009 |
| PubMed ID: 19969349 |
| |
| Bax DV, McKenzie DR, Weiss AS, Bilek MM, The linker-free covalent attachment of collagen to plasma immersion ion implantation treated polytetrafluoroethylene and subsequent cell-binding activity Biomaterials31:2526-34 2009 |
| PubMed ID: 20035993 |
| |
| Lin Z, Fontaine J, Watchko JF, Coexpression of gene polymorphisms involved in bilirubin production and metabolism Pediatrics122:e156-62 2008 |
| PubMed ID: 18558634 |
| |
| Compe E, Drané P, Laurent C, Diderich K, Braun C, Hoeijmakers JH, Egly JM, Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations Molecular and cellular biology25:6065-76 2005 |
| PubMed ID: 15988019 |
| |
| Russanova VR, Hirai TH, Howard BH, Semirandom sampling to detect differentiation-related and age-related epigenome remodeling The journals of gerontology Series A, Biological sciences and medical sciences59:1221-33 2005 |
| PubMed ID: 15699521 |
| |
| Sengupta S, Shimamoto A, Koshiji M, Pedeux R, Rusin M, Spillare EA, Shen JC, Huang LE, Lindor NM, Furuichi Y, Harris CC, Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene24(10):1738-48 2005 |
| PubMed ID: 15674334 |
| |
| Drané P, Compe E, Catez P, Chymkowitch P, Egly JM, Selective regulation of vitamin D receptor-responsive genes by TFIIH Molecular cell16:187-97 2004 |
| PubMed ID: 15494306 |
| |
| Reddel CJ, Weiss AS, Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome Journal of medical genetics41:715-7 2004 |
| PubMed ID: 15342704 |
| |
| Greco M, Villani G, Mazzucchelli F, Bresolin N, Papa S, Attardi G, Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts The FASEB journal : official publication of the Federation of American Societies for Experimental Biology17:1706-8 2003 |
| PubMed ID: 12958183 |
| |
| Zhang J, Asin-Cayuela J, Fish J, Michikawa Y, Bonafe M, Olivieri F, Passarino G, De Benedictis G, Franceschi C, Attardi G, Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A100(3):1116-21 2003 |
| PubMed ID: 12538859 |
| |
| Longo N, Wang Y, Smith SA, Langley SD, DiMeglio LA, Giannella-Neto D, Genotype-phenotype correlation in inherited severe insulin resistance. Hum Mol Genet11(12):1465-75 2002 |
| PubMed ID: 12023989 |
| |
| Hughes-Fulford M, Chen Y, Tjandrawinata RR, Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis22(5):701-7 2001 |
| PubMed ID: 11323387 |
| |
| Odaib AA, Shneider BL, Bennett MJ, Pober BR, Reyes-Mugica M, Friedman AL, Suchy FJ, Rinaldo P, A defect in the transport of long-chain fatty acids associated with acute liver failure. N Engl J Med339(24):1752-7 1998 |
| PubMed ID: 9845710 |
| |
| Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G, Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem271(27):15891-7 1996 |
| PubMed ID: 8663253 |
| |
| Zhao HG, Li HH, Bach G, Schmidtchen A, Neufeld EF, The molecular basis of Sanfilippo syndrome type B. Proc Natl Acad Sci U S A93:6101-5 1996 |
| PubMed ID: 8650226 |
| |
| Newsham I, Daub D, Besnard-Guerin C, Cavenee W, Molecular sublocalization and characterization of the 11;22 translocation breakpoint in a malignant rhabdoid tumor. Genomics19:433-40 1994 |
| PubMed ID: 8188285 |
| |
| Pienta KJ, Getzenberg RH, Coffey DS, Characterization of nuclear morphology and nuclear matrices in ageing human fibroblasts. Mech Ageing Dev62:13-24 1992 |
| PubMed ID: 1560681 |
| |
| Boyer JC, Kaufmann WK, Cordeiro-Stone M, Role of postreplication repair in transformation of human fibroblasts to anchorage independence. Cancer Res51:2960-4 1991 |
| PubMed ID: 1903328 |
| |
| Ganguly A, Baldwin CT, Strobel D, Conway D, Horton W, Prockop DJ, Heterozygous mutation in the G+5 position of intron 33 of the pro-alpha 2(I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta. Use of carbodiimide methods that decrease the extent of DNA sequencing necessary to define an unusual mutation. J Biol Chem266:12035-40 1991 |
| PubMed ID: 1711048 |
| |
| Kaufmann WK, Boyer JC, Estabrooks LL, Wilson SJ, Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes. Mol Cell Biol11:3711-8 1991 |
| PubMed ID: 1646393 |
| |
| Tlsty TD, Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci U S A87:3132-6 1990 |
| PubMed ID: 2326271 |
| |
| Nicotera TM, Notaro J, Notaro S, Schumer J, Sandberg AA, Elevated superoxide dismutase in Bloom's syndrome: a genetic condition of oxidative stress. Cancer Res49:5239-43 1989 |
| PubMed ID: 2766291 |
| |
| Sanan DA, van der Westhuyzen DR, Gevers W, Coetzee GA, Early appearance of dispersed low density lipoprotein receptors on the fibroblast surface during recycling. Eur J Cell Biol48:327-36 1989 |
| PubMed ID: 2744006 |
| |
| Dombrowski KE, Prockop DJ, Cleavage of type I and type II procollagens by type I/II procollagen N- proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates. J Biol Chem263:16545-52 1988 |
| PubMed ID: 3053692 |
| |
| Nagasawa H, Little JB, Radiosensitivities of ten apparently normal human diploid fibroblast strains to cell killing, G2-phase chromosomal aberrations, and cell cycle delay. Cancer Res48:4535-8 1988 |
| PubMed ID: 3396006 |
| |
| Sephel GC, Sturrock A, Giro MG, Davidson JM, Increased elastin production by progeria skin fibroblasts is controlled by the steady-state levels of elastin mRNA. J Invest Dermatol90:643-7 1988 |
| PubMed ID: 3361140 |
| |
| Williams ML, Monger DJ, Rutherford SL, Hincenbergs M, Rehfeld SJ, Grunfeld C, Neutral lipid storage disease with ichthyosis: lipid content and metabolism of fibroblasts. J Inherit Metab Dis11:131-43 1988 |
| PubMed ID: 3139924 |
| |
| Harper GS, Hascall VC, Yanagishita M, Gahl WA, Proteoglycan synthesis in normal and Lowe syndrome fibroblasts. J Biol Chem262:5637-43 1987 |
| PubMed ID: 3571227 |
| |
| Heath-Monnig E, Wohltmann HJ, Mills-Dunlap B, Daughaday WH, Measurement of insulin-like growth factor I (IGF-I) responsiveness of fibroblasts of children with short stature: identification of a patient with IGF-I resistance. J Clin Endocrinol Metab64:501-7 1987 |
| PubMed ID: 3818890 |
| |
| Lin PY, Gruenstein E, Identification of a defective cAMP-stimulated Cl- channel in cystic fibrosis fibroblasts. J Biol Chem262:15345-7 1987 |
| PubMed ID: 2445735 |
| |
| Wood CM, Timme TL, Hurt MM, Brinkley BR, Ledbetter DH, Moses RE, Transformation of DNA repair-deficient human diploid fibroblasts with a simian virus 40 plasmid. Exp Cell Res169:543-53 1987 |
| PubMed ID: 3030788 |
| |
| Cordeiro-Stone M, Boyer JC, Smith BA, Kaufmann WK, Effect of benzo[a]pyrene-diol-epoxide-I on growth of nascent DNA in synchronized human fibroblasts. Carcinogenesis7:1775-81 1986 |
| PubMed ID: 3093114 |
| |
| de Wett W, Sippola M, Tromp G, Prockop D, Chu ML, Ramirez F, Use of R-loop mapping for the assessment of human collagen mutations. J Biol Chem261:3857-62 1986 |
| PubMed ID: 3949794 |
| |
| Hinman LM, Ksiezak-Reding H, Baker AC, Blass JP, Pigeon liver phosphoprotein phosphatase: an effective activator of pyruvate dehydrogenase in tissue homogenates. Arch Biochem Biophys246:381-90 1986 |
| PubMed ID: 3008658 |
| |
| Little LE, Mueller OT, Honey NK, Shows TB, Miller AL, Heterogeneity of N-acetylglucosamine 1-phosphotransferase within mucolipidosis III. J Biol Chem261:733-8 1986 |
| PubMed ID: 3001079 |
| |
| Nove J, Little JB, Mayer PJ, Troilo P, Nichols WW, Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. Mutat Res163:255-62 1986 |
| PubMed ID: 3785261 |
| |
| Sephel GC, Davidson JM, Elastin production in human skin fibroblast cultures and its decline with age. J Invest Dermatol86:279-85 1986 |
| PubMed ID: 3745952 |
| |
| Brinker JM, Gudas LJ, Loidl HR, Wang SY, Rosenbloom J, Kefalides NA, Myers JC, Restricted homology between human alpha 1 type IV and other procollagen chains. Proc Natl Acad Sci U S A82:3649-53 1985 |
| PubMed ID: 2582422 |
| |
| Emanuel BS, Cannizzaro LA, Seyer JM, Myers JC, Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2. Proc Natl Acad Sci U S A82:3385-9 1985 |
| PubMed ID: 3858826 |
| |
| Kaufmann WK, Boyer JC, Smith BA, Cordeiro-Stone M, DNA repair and replication in human fibroblasts treated with (+/-)-r- 7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene . Biochim Biophys Acta824:146-51 1985 |
| PubMed ID: 3970929 |
| |
| Dickson LA, Pihlajaniemi T, Deak S, Pope FM, Nicholls A, Prockop DJ, Myers JC, Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide- coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta. Proc Natl Acad Sci U S A81:4524-8 1984 |
| PubMed ID: 6087329 |
| |
| Sippola M, Kaffe S, Prockop DJ, A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase. J Biol Chem259:14094-100 1984 |
| PubMed ID: 6438090 |
| |
| Wright PS, McKinney E, Berry S, Evers A, Kent C, A functional membrane repair system in Duchenne muscular dystrophy fibroblasts. J Neurol Sci64:259-64 1984 |
| PubMed ID: 6088703 |
| |
| de Wet WJ, Chu ML, Prockop DJ, The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs. J Biol Chem258:14385-9 1983 |
| PubMed ID: 6689020 |
| |
| Durham HD, Pena SD, Carpenter S, The neurotoxins 2,5-hexanedione and acrylamide promote aggregation of intermediate filaments in cultured fibroblasts. Muscle Nerve6:631-637 1983 |
| PubMed ID: 6361548 |
| |
| Kent C, Increased rate of cell-substratum detachment of fibroblasts from patients with Duchenne muscular dystrophy. Proc Natl Acad Sci U S A80:3086-90 1983 |
| PubMed ID: 6574472 |
| |
| Merrill AH Jr, Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim Biophys Acta754:284-91 1983 |
| PubMed ID: 6652105 |
| |
| Pato CN, Davis MH, Doughty MJ, Bryant SH, Gruenstein E, Increased membrane permeability to chloride in Duchenne muscular dystrophy fibroblasts and its relationship to muscle function. Proc Natl Acad Sci U S A80:4732-6 1983 |
| PubMed ID: 6576355 |
| |
| Taylor MW, Kothari RM, Holland GD, Martinez-Valdez H, Zeige G, A comparison of purine and pyrimidine pools in Bloom's syndrome and normal cells. Cancer Biochem Biophys7:19-25 1983 |
| PubMed ID: 6667451 |
| |
| Weitz G, Lindl T, Hinrichs U, Sandhoff K, Release of sphingomyelin phosphodiesterase (acid sphingomyelinase) by ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes. Hoppe Seylers Z Physiol Chem364:863-71 1983 |
| PubMed ID: 6311712 |
| |
| Barak LS, Webb WW, Diffusion of low density lipoprotein-receptor complex on human fibroblasts. J Cell Biol95:846-52 1982 |
| PubMed ID: 6296157 |
| |
| Davis MH, Pato CN, Grinvalsky H, Gruenstein E, Identification of a biochemical difference between male and female human fibroblasts: implications for the expression of Duchenne muscular dystrophy. Neurology32:951-7 1982 |
| PubMed ID: 7202167 |
| |
| Barak LS, Webb WW, Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts. J Cell Biol90:595-604 1981 |
| PubMed ID: 6270157 |
| Passage Frozen |
5 |
| Split Ratio |
1:2 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Percent O2 |
AMBIENT |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Supplement |
- |
|