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AG15694 LCL from B-Lymphocyte

Description:

PROGERIA, ADULT ONSET

Affected:

Yes

Sex:

Female

Age:

25 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Heritable Diseases
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source LCL from B-Lymphocyte
Family Member 2
Relation to Proband daughter
Confirmation Clinical summary/Case history
ISCN 46,XX
Species Homo sapiens
Common Name Human
Remarks Donor has an affected father, paternal grandmother, and 2 affected sisters. The culture was initiated on 9/4/98 by transformation of lymphocytes with Epstein Barr virus. The cells grow in suspension and their morphology is spherical. A lymphoblast culture from this donor's affected father is AG15693 and donor's affected sister is AG15695.

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis
 

Phenotypic Data

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Remarks Donor has an affected father, paternal grandmother, and 2 affected sisters. The culture was initiated on 9/4/98 by transformation of lymphocytes with Epstein Barr virus. The cells grow in suspension and their morphology is spherical. A lymphoblast culture from this donor's affected father is AG15693 and donor's affected sister is AG15695.

Publications

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Heyn H, Moran S, Esteller M, Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome. Epigenetics8(1):28-33 2013
PubMed ID: 23257959

Culture Protocols

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Split Ratio 1:4
Temperature 37 C
Percent CO2 5%
Medium Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not Inactivated
Substrate None specified
Subcultivation Method dilution - add fresh medium
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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How to Order
  • Ordering Instructions
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