I90-19
Fibroblast from Lung, Lung
Description:
IMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST
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Repository
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NIA Aging Cell Culture Repository
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| Subcollection |
IMR90/IMR91 Cell Cultures
Specially Characterized Fibroblasts |
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Biopsy Source
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Lung
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Cell Type
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Fibroblast
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Tissue Type
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Lung
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Transformant
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Untransformed
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Sample Source
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Fibroblast from Lung, Lung
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Race
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White
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Relation to Proband
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proband
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| PDL at Freeze |
25 |
| Passage Frozen |
8 |
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| Remarks |
The IMR-90 line was established on 7/7/75 using explants of minced lung tissue obtained from a clinically normal 16 week fetus. The karyotype is 46,XX; normal diploid female. No variant isoenzyme patterns found for lactate dehydrogenase, malate dehydrogenase, 6-phosphogluconate dehydrogenase, and glucose-6-phosphate dehydrogenase; G6PD is isoenzyme type B. The HLA type is A2, B12, BW40, B5. Reverse transcriptase was not detected. The maximum number of population doublings achieved to senescence range from 58-73. Earlier passage IMR-90 cells available only with permission of NIA: see guidelines in Science 196:60-63 (1977). The legacy karyotype description shown in this Remark may not be representative of the current available product. |
| Lussier-Price M, Wahba HM, Mascle XH, Cappadocia L, Bourdeau V, Gagnon C, Igelmann S, Sakaguchi K, Ferbeyre G, Omichinski JG, Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1 Nucleic acids research: 2022 |
| PubMed ID: 35871297 |
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| Del Toro N, Lessard F, Bouchard J, Mobasheri N, Guillon J, Igelmann S, Tardif S, Buffard T, Bourdeau V, Brakier-Gingras L, Ferbeyre G, Cellular Senescence limits Translational Readthrough Biology open: 2021 |
| PubMed ID: 34676390 |
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| Barnes JW, Duncan D, Helton S, Hutcheson S, Kurundkar D, Logsdon NJ, Locy M, Garth J, Denson R, Farver C, Vo HT, King G, Kentrup D, Faul C, Kulkarni T, De Andrade JA, Yu Z, Matalon S, Thannickal VJ, Krick S, Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis American journal of physiology Lung cellular and molecular physiology317:L141-L154 2020 |
| PubMed ID: 31042083 |
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| Locy ML, Rangarajan S, Yang S, Johnson MR, Bernard K, Kurundkar A, Bone NB, Zmijewski JW, Byun J, Pennathur S, Zhou Y, Thannickal VJ, Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular migration Science signaling13:L141-L154 2020 |
| PubMed ID: 32788339 |
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| Zannas AS, Kosyk O, Leung CS, Prolonged Glucocorticoid Exposure Does Not Accelerate Telomere Shortening in Cultured Human Fibroblasts Genes11:L141-L154 2020 |
| PubMed ID: 33261163 |
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| Caputo L, Granados A, Lenzi J, Rosa A, Ait-Si-Ali S, Puri PL, Albini S, Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFß-dependent pro-fibrotic signaling Skeletal muscle10:13 2019 |
| PubMed ID: 32359374 |
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| Dall'Agnese A, Caputo L, Nicoletti C, di Iulio J, Schmitt A, Gatto S, Diao Y, Ye Z, Forcato M, Perera R, Bicciato S, Telenti A, Ren B, Puri PL, Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation Molecular cell10:13 2019 |
| PubMed ID: 31519520 |
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| Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y, Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids Cell reports Medicine1:100002 2019 |
| PubMed ID: 33205055 |
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| Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V, Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties Nature communications11:2376 2019 |
| PubMed ID: 32398747 |
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| Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I, Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides Cell Metabolism28:817-832 2018 |
| PubMed ID: 30244971 |
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| Sanders YY, Liu H, Zhang X, Hecker L, Hernard K, Desai L, Liu G, Thannickal VJ, Histone modifications in senescence-associated resistance to apoptosis by oxidative stress Redox Biol1(1):8-16 2013 |
| PubMed ID: 24024133 |
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| Vallot C, Huret C, Lesecque Y, Resch A, Oudrhiri N, Bennaceur-Griscelli A, Duret L, Rougeulle C, XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells Nat Genet45(3):239-41 2013 |
| PubMed ID: 23334669 |
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| Mao Z, Ke Z, Gobunova V, Seluanov A., Replicatively senescent cells are arrested in G1 and G2 phases. Aging4:431-5 2012 |
| PubMed ID: 22745179 |
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| Cho JH, Saini DK, Karunarathne WK, Kalyanaraman V, Gautam N., Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit. Cell Signal23:785-93 2011 |
| PubMed ID: 21238584 |
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| Ghandhi SA, Ming L, Ivanov VN, Hei TK, Amundson SA, Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts BMC medical genomics3:31 2010 |
| PubMed ID: 20670442 |
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| Ivanov VN, Zhou H, Ghandhi SA, Karasic TB, Yaghoubian B, Amundson SA, Hei TK, Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission Cellular signalling22:1076-87 2010 |
| PubMed ID: 20206688 |
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| Eymery A, Souchier C, Vourc'h C, Jolly C, Heat shock factor 1 binds to and transcribes satellite II and III sequences at several pericentromeric regions in heat-shocked cells Experimental cell research316:1845-55 2009 |
| PubMed ID: 20152833 |
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| Gamerdinger M, Clement AB, Behl C, Cholesterol-Like Effects of Selective Cyclooxygenase Inhibitors and Fibrates on Cellular Membranes and Amyloid-beta Production Molecular pharmacology72:141-51 2007 |
| PubMed ID: 17395689 |
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| Milam JE, Keshamouni VG, Phan SH, Hu B, Gangireddy SR, Hogaboam CM, Standiford TJ, Thannickal VJ, Reddy RC, PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis American journal of physiology Lung cellular and molecular physiology294:L891-901 2007 |
| PubMed ID: 18162602 |
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| Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN, Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts The Journal of nutrition137:25-30 2006 |
| PubMed ID: 17182796 |
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| Gosslau A, Chen M, Ho CT, Chen KY, A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts Br J Cancer92(3):513-21 2005 |
| PubMed ID: 15668717 |
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| Kern A, Roempp B, Prager K, Walter J, Behl C, Down-regulation of endogenous amyloid precursor protein processing due to cellular aging The Journal of biological chemistry281:2405-13 2005 |
| PubMed ID: 16303768 |
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| Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass CK, Rosenfeld MG, Myers RM, Ren B, Direct isolation and identification of promoters in the human genome Genome research15:830-9 2005 |
| PubMed ID: 15899964 |
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| White ES, Atrasz RG, Hu B, Phan SH, Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos CD, Toews GB, Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10) American journal of respiratory and critical care medicine173:112-21 2005 |
| PubMed ID: 16179636 |
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| Yin Z, Watsky MA, Chloride channel activity in human lung fibroblasts and myofibroblasts American journal of physiology Lung cellular and molecular physiology288:L1110-6 2005 |
| PubMed ID: 15681397 |
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| Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T, Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev18(17):2108-19 2004 |
| PubMed ID: 15342490 |
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| White ES, Atrasz RG, Dickie EG, Aronoff DM, Stambolic V, Mak TW, Moore BB, Peters-Golden M, Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity American journal of respiratory cell and molecular biology32:135-41 2004 |
| PubMed ID: 15539459 |
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| Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN, ATM and ATR: sensing DNA damage. World J Gastroenterol10(2):155-60 2004 |
| PubMed ID: 14716813 |
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| Baird DM, Rowson J, Wynford-Thomas D, Kipling D, Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet33(2):203-7 2003 |
| PubMed ID: 12539050 |
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| Forsyth NR, Evans AP, Shay JW, Wright WE, Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell2(5):235-43 2003 |
| PubMed ID: 14570231 |
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| Li GZ, Eller MS, Firoozabadi R, Gilchrest BA, Evidence that exposure of the telomere 3' overhang sequence induces senescence Proceedings of the National Academy of Sciences of the United States of America100:527-31 2003 |
| PubMed ID: 12515865 |
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| Parada C, Hernandez Losa J, Guinea J, Sanchez-Arevalo V, Fernandez Soria V, Alvarez-Vallina L, Sanchez-Prieto R, Ramon Y Cajal S, Adenovirus E1a protein enhances the cytotoxic effects of the herpes thymidine kinase-ganciclovir system. Cancer Gene Ther10(2):152-60 2003 |
| PubMed ID: 12536204 |
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| Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE, Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase The Journal of biological chemistry278:12384-9 2003 |
| PubMed ID: 12531888 |
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| Borel F, Lohez OD, Lacroix FB, Margolis RL, Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells Proc Natl Acad Sci U S A99(15):9819-24 2002 |
| PubMed ID: 12119403 |
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| Deddish PA, Marcic BM, Tan F, Jackman HL, Chen Z, Erdos EG, Neprilysin inhibitors potentiate effects of bradykinin on b2 receptor. Hypertension39(2 Pt 2):619-23 2002 |
| PubMed ID: 11882619 |
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| Gabai VL, Mabuchi K, Mosser DD, Sherman MY, Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol22(10):3415-24 2002 |
| PubMed ID: 11971973 |
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| Shreeram S, Sparks A, Lane DP, Blow JJ, Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene21(43):6624-32 2002 |
| PubMed ID: 12242660 |
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| Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ, ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chemepub ahead of print:6624-32 2002 |
| PubMed ID: 11821415 |
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| Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J, SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev16(5):571-82 2002 |
| PubMed ID: 11877377 |
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| Zhang X, Shu L, Hosoi H, Murti KG, Houghton PJ, Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. J Biol Chem277(31):28127-34 2002 |
| PubMed ID: 12000755 |
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| Andreassen PR, Lohez OD, Lacroix FB, Margolis RL, Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell12(5):1315-28 2001 |
| PubMed ID: 11359924 |
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| Atamna H, Liu J, Ames BN, Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to aging. J Biol Chem276(51):48410-6 2001 |
| PubMed ID: 11598132 |
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| Atamna H, Robinson C, Ingersoll R, Elliott H, Ames BN, N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro. FASEB J15(12):2196-204 2001 |
| PubMed ID: 11641246 |
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| Danam RP, Howell SR, Remack JS, Brent TP, Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. Int J Oncol18(6):1187-93 2001 |
| PubMed ID: 11351250 |
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| Guo W, Okamoto M, Park NH, Lee YM, Park NH, Cloning and expression of hamster telomerase catalytic subunit cDNA. Int J Mol Med8(1):73-8 2001 |
| PubMed ID: 11408953 |
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| Yang X, Taylor L, Polgar P, p53 down-regulates human bradykinin B1 receptor gene expression. J Cell Biochem82(1):38-45 2001 |
| PubMed ID: 11400161 |
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| Yang X, Taylor L, Yu J, Fenton MJ, Polgar P, Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process. J Cell Biochem82(1):163-70 2001 |
| PubMed ID: 11400173 |
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| Atamna H, Cheung I, Ames BN, A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A97(2):686-91 2000 |
| PubMed ID: 10639140 |
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| Atamna H, Paler-Martinez A, Ames BN, N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J Biol Chem275:6741-8 2000 |
| PubMed ID: 10702229 |
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| Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW, PML is induced by oncogenic ras and promotes premature senescence. Genes Dev14(16):2015-27 2000 |
| PubMed ID: 10950866 |
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| Yang X, He Z, Xin B, Cao L, LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression Oncogene19(16):2002-13 2000 |
| PubMed ID: 10803461 |
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| Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ, Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic Biol Med26(3-4):419-30 1999 |
| PubMed ID: 9895234 |
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| Chiou WJ, Wang J, Berg CE, Wu-Wong JR, SV40 virus transformation down-regulates endothelin receptor. Biochim Biophys Acta1450(1):35-44 1999 |
| PubMed ID: 10231553 |
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| Hay JG, Shapiro N, Sauthoff H, Heitner S, Phupakdi W, Rom WN, Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: the importance of the adenoviral E1b-55kD gene. Hum Gene Ther10(4):579-90 1999 |
| PubMed ID: 10094201 |
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| Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T, p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science283(5406):1321-5 1999 |
| PubMed ID: 10037601 |
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| Martelli F, Livingston DM, Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc Natl Acad Sci U S A96:2858-63 1999 |
| PubMed ID: 10077601 |
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| Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW, Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun254(3):795-803 1999 |
| PubMed ID: 9920820 |
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| Rudolph C, Adam G, Simm A, Determination of copy number of c-Myc protein per cell by quantitative Western blotting. Anal Biochem269(1):66-71 1999 |
| PubMed ID: 10094776 |
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| Suzuki K, Kazui T, Yoshida M, Uno T, Kobayashi T, Kimura T, Yoshida T, Sugimura H, Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro. Jpn J Clin Oncol29(7):323-31 1999 |
| PubMed ID: 10470656 |
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| Choung J, Taylor L, Thomas K, Zhou X, Kagan H, Yang X, Polgar P, Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. J Cell Biochem71(2):254-63 1998 |
| PubMed ID: 9779823 |
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| Lukiw WJ, Bazan NG, Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J Neurosci Res53(5):583-92 1998 |
| PubMed ID: 9726429 |
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| Stein GH, Dulic V, Molecular mechanisms for the senescent cell cycle arrest. J Investig Dermatol Symp Proc3(1):14-8 1998 |
| PubMed ID: 9732051 |
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| Yang X, Taylor L, Polgar P, Mechanisms in the transcriptional regulation of bradykinin B1 receptor gene expression. Identification of a minimum cell-type specific enhancer. J Biol Chem273(17):10763-70 1998 |
| PubMed ID: 9553142 |
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| Zhou X, Polgar P, Taylor L, Roles for interleukin-1beta, phorbol ester and a post-transcriptional regulator in the control of bradykinin B1 receptor gene expression Biochem J330 ( Pt 1):361-6 1998 |
| PubMed ID: 9461531 |
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| PubMed ID: 9213441 |
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| Krupsky M, Kuang PP, Goldstein RH, Regulation of type I collagen mRNA by amino acid deprivation in human lung fibroblasts. J Biol Chem272:13864-8 1997 |
| PubMed ID: 9153245 |
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| PubMed ID: 9054505 |
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| PubMed ID: 9105039 |
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| Saito H, Papaconstantinou J, Sato H, Goldstein S, Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence. J Biol Chem272:8157-60 1997 |
| PubMed ID: 9079631 |
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| Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL, Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. Eur J Cell Biol69(3):236-44 1996 |
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| Harris LC, Remack JS, Houghton PJ, Brent TP, Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene. Cancer Res56(9):2029-32 1996 |
| PubMed ID: 8616846 |
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| PubMed ID: 8625442 |
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| PubMed ID: 8872612 |
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| PubMed ID: 7559606 |
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| Halle JP, Schmidt C, Adam G, Changes of the methylation pattern of the c-myc gene during in vitro aging of IMR90 human embryonic fibroblasts. Mutat Res316(4):157-71 1995 |
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| PubMed ID: 7887426 |
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| PubMed ID: 7698226 |
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| Chang ZF, Huang DY, Decline of protein kinase C activation in response to growth stimulation during senescence of IMR-90 human diploid fibroblasts. Biochem Biophys Res Commun200:16-27 1994 |
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| PubMed ID: 8179821 |
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| Rubelj I, Pereira-Smith OM, SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence. Exp Cell Res211:82-9 1994 |
| PubMed ID: 7510251 |
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| PubMed ID: 8116699 |
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| PubMed ID: 8168839 |
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| Vannini F, Meacci E, Vasta V, Farnararo M, Bruni P, Involvement of protein kinase C and arachidonate signaling pathways in the alteration of proliferative response of senescent IMR-90 human fibroblasts. Mech Ageing Dev76:101-11 1994 |
| PubMed ID: 7885058 |
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| Jackson BA, Goldstein RH, Roy R, Cozzani M, Taylor L, Polgar P, Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem Biophys Res Commun197(3):1465-74 1993 |
| PubMed ID: 8280164 |
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| PubMed ID: 8476635 |
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| Manfioletti G, Brancolini C, Avanzi G, Schneider C, The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol13(8):4976-85 1993 |
| PubMed ID: 8336730 |
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| PubMed ID: 8402685 |
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| PubMed ID: 7690594 |
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| Wu C, Zannis-Hadjopoulos M, Price GB, In vivo activity for initiation of DNA replication resides in a transcribed region of the human genome. Biochim Biophys Acta1174(3):258-66 1993 |
| PubMed ID: 8373803 |
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| Baenziger NL, Jong YJ, Yocum SA, Dalemar LR, Wilhelm B, Vavrek R, Stewart JM, Diversity of B2 bradykinin receptors with nanomolar affinity expressed in passaged IMR90 human lung fibroblasts. Eur J Cell Biol58(1):71-80 1992 |
| PubMed ID: 1322819 |
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| Cumulative PDL at Freeze |
25 |
| Passage Frozen |
8 |
| Split Ratio |
1:5 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Percent O2 |
AMBIENT |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
trypsin-EDTA |
| Supplement |
- |
|
|