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NG04656 DNA from Fibroblast

Description:

GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA)

Affected:

No

Sex:

Male

Age:

39 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection GRC
Quantity 10 µg
Quantitation Method Please see our FAQ
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source DNA from Fibroblast
Race White
Family Member 1
Relation to Proband proband
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The biopsy site is the mesial aspect of the mid-upper left arm, taken antemortem. The primary culture was initiated from explants of a 2 mm-punch biopsy. The cell morphology is fibroblast-like and the karyotype is 46,XY with 18% of the cells examined showing random chromosomal abnormalities. Donor is diabetic and hypertensive. He has psoriasis, but was not treated with psoralen-UVA. A culture initiated from a biopsy taken 15 years later from this same donor is AG13075. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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PDL at Senescence 45
PDL at Freeze 9
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Chromosome Analysis
 

Phenotypic Data

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Remarks The biopsy site is the mesial aspect of the mid-upper left arm, taken antemortem. The primary culture was initiated from explants of a 2 mm-punch biopsy. The cell morphology is fibroblast-like and the karyotype is 46,XY with 18% of the cells examined showing random chromosomal abnormalities. Donor is diabetic and hypertensive. He has psoriasis, but was not treated with psoralen-UVA. A culture initiated from a biopsy taken 15 years later from this same donor is AG13075. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Sephel GC, Davidson JM, Elastin production in human skin fibroblast cultures and its decline with age. J Invest Dermatol86:279-85 1986
PubMed ID: 3745952
 
Schneider EL, Monticone R, Smith J, Braunschweiger K, Roberts T, Skin fibroblast cultures derived from members of the Baltimore longitudinal study: a new resource for studies of cellular aging. Cytogenet Cell Genet31:40-6 1981
PubMed ID: 7307581

External Links

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dbSNP dbSNP ID: 15685
Pricing
Commercial:
$155.00USD
Academic &
Non-profit:
$72.00USD
NIA Grantees:
$62.00USD
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  • AG04656 - Fibroblast
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