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dbGaP Study Detail Description:
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The National Institute of Neurological Disorders and Stroke (NINDS) Human Genetics Resource Center: DNA and Cell Line Repository (the NINDS Repository), banks phenotypic data and biological samples, including from individuals with cerebrovascular disease, in order to facilitate gene discovery in neurological disorders. Those samples are used in a number of studies, and genotyping data from studies using this resource are encouraged to be shared via dbGaP. Many studies have already shared data in this fashion, which in turn, can be linked back to the biologicals banked at the NINDS Repository.
Stroke is the third leading cause of death in the United States, and is an acute neurological event leading to death of neural tissues. Although the majority of strokes are ischemic strokes, meaning there is oxygen deprivation to the brain, almost 20% of strokes are hemorrhagic, resulting from bleeding into the brain. Samples available in cerebrovascular disease in the NINDS Repository, include but are not limited to those from individuals affected with the following: ischemic stroke, hemorrhagic stroke, intracranial aneurysm (both ruptured and unruptured), transient ischemic attack, arteriovenous malformations, and others. Many studies contribute to the NINDS Repository collection in an ongoing manner and others are being added regularly. These studies include samples from the Vitamin Intervention for Stroke Prevention (VISP) study, the Ischemic Stroke Genetics Study (ISGS), the Familial Intracranial Aneurysm study, and many others.
There is also an associated Control collection (see dbGaP and Coriell). Others studies may use cases from the NINDS repository, controls from the NINDS repository, as well as cases, and controls, from other sources. A subset of subjects from The National Institute of Neurological Disorders and Stroke (NINDS) Human Genetics Resource Center: DNA and Cell Line Repository (the NINDS Repository): Cerebrovascular Disease/Stroke Study was utilized in the Ischemic Stroke Genetics Study (ISGS) study.
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