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NIA

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Specially Characterized Normal Human Diploid Fibroblast Cultures

This collection includes the IMR-90 (female) and IMR-91 (male), human fetal lung fibroblast lines which were developed expressly for the NIA Aging Cell Repository and are available at low, intermediate, and high population doublings. IMR-91 diploid male fetal skin fibroblasts cultures are also available at low, intermediate, and high population doublings. Included in this collection is WI-38 (AG06814 - female) which was the first diploid cell strain developed and utilized for the study of aging at the cellular level. WI-38 is available at population doublings levels 14, 22, 34, and 44. The Repository also distributes TIG-1 (AG06173 - female) which was developed in Japan for use in aging research. MRC-5 (AG05965 - male) from Britain, another well characterized diploid human fetal lung fibroblast cell strain, is available at three population doubling levels. All of these cultures have been widely used for aging studies and an extensive literature details the role they have played in research on the causes and effects of aging at the cellular level as well as many other biochemical studies.

Catalog IDCell TypeDescriptionPopulation
Doubling
SexAge
I90-79FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST17Female16 FW
I90-10FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST19Female16 FW
I90-15FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST21Female16 FW
I90-19FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST25Female16 FW
I90-24FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST27Female16 FW
I90-26FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST30Female16 FW
I90-33FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST33Female16 FW
I90-40FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST36Female16 FW
I90-53FibroblastIMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST40Female16 FW
AG02804FibroblastIMR-90 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST Female16 FW
AG03204FibroblastIMR-90 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST47Female16 FW
I91S-05FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST10Male12 FW
I91S-08FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST11Male12 FW
I91S-04FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST14Male12 FW
I91L-07FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST15Male12 FW
I91L-12FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST19Male12 FW
I91L-13FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST22Male12 FW
I91L-15FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST26Male12 FW
I91L-16FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST30Male12 FW
I91L-17FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST33Male12 FW
I91L-18FibroblastIMR-91 - NORMAL HUMAN FETAL FIBROBLAST37Male12 FW
AG05965-GFibroblastMRC-5 - NORMAL HUMAN FETAL LUNG FIBROBLAST5.51Male14 FW
AG05965-CFibroblastMRC-5 - NORMAL HUMAN FETAL LUNG FIBROBLAST27Male14 FW
AG05965-DFibroblastMRC-5 - NORMAL HUMAN FETAL LUNG FIBROBLAST40Male14 FW
AG10076FibroblastMRC-5 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST5.94Male14 FW
AG06173FibroblastTIG-1 - NORMAL HUMAN FETAL LUNG FIBROBLAST17Female20 FW
AG06814-JFibroblastWI-38 - NORMAL HUMAN FETAL LUNG FIBROBLAST Female12 FW
AG06814-MFibroblastWI-38 - NORMAL HUMAN FETAL LUNG FIBROBLAST34Female12 FW
AG07217FibroblastWI-38 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST Female12 FW

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