Overview of Motor Neuron Diseases including Amyotrophic Lateral Sclerosis
Motor Neuron Disease (MND) classifies a group of disorders that affect muscle activity. Motor neurons, which are responsible for transmitting signals from the nervous system to muscles, are impaired in this class of disorders. Motor neuron impairment can cause problems in tasks involving muscle function such as walking, swallowing and breathing. These diseases are degenerative and the extent of symptoms associated with MND varies, as does age of onset, prognosis, and the risk of fatality.
The NINDS Repository MND collection includes biomaterials from subjects with Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig’s Disease), Progressive Muscular Atrophy, Primary Lateral Sclerosis and Progressive Bulbar Palsy. The Repository also banks subjects with MNDs that have known genetic causes, including Spinal Bulbar Muscular Atrophy (Kennedy’s Disease) and Spinal Muscular Atrophy. Also included in the collection are unaffected (“At Risk”) and affected blood relatives of subjects, spouses (spousal controls), and normal healthy individuals (including population and convenience controls).
Motor Neuron Diseases Sample Catalog
Questions?You may contact the NINDS Repository team at NINDS@Coriell.org.
References for ALS Criteria
References and Selected Reading
- Required Clinical Data Elements for subjects with Motor Neuron Diseases(CDEs)
- Clinical Data Elements (CDEs) for Motor Neuron Diseases Data Dictionary
- Clinical Data Elements (CDEs) for Controls
- Clinical Data Elements (CDEs) for Controls Data Dictionary
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