GM00607
LCL from B-Lymphocyte
Description:
APPARENTLY HEALTHY INDIVIDUAL
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Apparently Healthy Collection |
| Alternate IDs |
GM17206 [APPARENTLY HEALTHY INDIVIDUAL] |
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Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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LCL from B-Lymphocyte
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Race
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White
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Relation to Proband
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proband
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
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| IMMUNOGLOBULIN PRODUCTION |
Lymphoid Culture Secretes IgM (Kappa) |
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| Remarks |
46,XX,19p+; secretes IgM (Kappa) |
| Atwal GS, Bond GL, Metsuyanim S, Papa M, Friedman E, Distelman-Menachem T, Ben Asher E, Lancet D, Ross DA, Sninsky J, White TJ, Levine AJ, Yarden R, Haplotype structure and selection of the MDM2 oncogene in humans Proceedings of the National Academy of Sciences of the United States of America104:4524-9 2007 |
| PubMed ID: 17360557 |
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| Gong Y, Beitelshees AL, Wessel J, Langaee TY, Schork NJ, Johnson JA, Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit Pharmacogenetics and genomics17:267-75 2007 |
| PubMed ID: 17496725 |
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| Harris SL, Gil G, Robins H, Hu W, Hirshfield K, Bond E, Bond G, Levine AJ, Detection of functional single-nucleotide polymorphisms that affect apoptosis Proceedings of the National Academy of Sciences of the United States of America102:16297-302 2005 |
| PubMed ID: 16260726 |
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| Sotamaa K, Liyanarachchi S, Mecklin JP, Järvinen H, Aaltonen LA, Peltomäki P, de la Chapelle A, p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome Clinical cancer research : an official journal of the American Association for Cancer Research11:6840-4 2005 |
| PubMed ID: 16203772 |
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| Adachi M, Cossman J, Longo D, Croce CM, Tsujimoto Y, Variant translocation of the bcl-2 gene to immunoglobulin lambda light chain gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A86:2771-4 1989 |
| PubMed ID: 2704746 |
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| Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM, Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A86:5039-43 1989 |
| PubMed ID: 2740341 |
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| Meeker TC, Grimaldi JC, O'Rourke R, Louie E, Juliusson G, Einhorn S, An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy. Blood74:1801-6 1989 |
| PubMed ID: 2790203 |
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| Tsujimoto Y, Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells. Proc Natl Acad Sci U S A86:1958-62 1989 |
| PubMed ID: 2538824 |
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| Klobeck HG, Zimmer FJ, Combriato G, Zachau HG, Linking of the human immunoglobulin VK and JKCK regions by chromosomal walking. Nucleic Acids Res15:9655-65 1987 |
| PubMed ID: 3122178 |
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| Klobeck HG, Zachau HG, The human CK gene segment and the kappa deleting element are closely linked. Nucleic Acids Res14:4591-603 1986 |
| PubMed ID: 3086844 |
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| Nagarajan L, Louie E, Tsujimoto Y, ar-Rushdi A, Huebner K, Croce CM, Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias. Proc Natl Acad Sci U S A83:2556-60 1986 |
| PubMed ID: 3458216 |
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| Sun LK, Showe LC, Croce CM, Analysis of the 3' flanking region of the human c-myc gene in lymphomas with the t(8;22) and t(2;8) chromosomal translocations. Nucleic Acids Res14:4037-50 1986 |
| PubMed ID: 3714470 |
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| Weir L, Leder P, Structure and expression of a human subgroup II immunoglobulin kappa gene. Nucleic Acids Res14:3957-70 1986 |
| PubMed ID: 3086847 |
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| Giometti CS, Anderson NL, Tropomyosin heterogeneity in human cells. J Biol Chem259:14113-20 1984 |
| PubMed ID: 6501290 |
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| Kaplan DR, Henkel TJ, Braciale V, Braciale TJ, Mycoplasma infection of cell cultures: thymidine incorporation of culture supernatants as a screening test. J Immunol132:9-11 1984 |
| PubMed ID: 6361127 |
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| Erikson J, ar-Rushdi A, Drwinga HL, Nowell PC, Croce CM, Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma. Proc Natl Acad Sci U S A80:820-824 1983 |
| PubMed ID: 6402776 |
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| Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce CM, Differential expression of the normal and of the translocated human c- myc oncogenes in B cells. Proc Natl Acad Sci U S A80:4822-6 1983 |
| PubMed ID: 6308654 |
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| Shipp MA, Schwartz BD, Kannapell CC, Griffith RC, Scott MG, Ahmed P, Davie JM, Nahm MH, A unique DR-related B cell differentiation antigen. J Immunol131:2458-67 1983 |
| PubMed ID: 6415171 |
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| Anderson NL, Giometti CS, Gemmell MA, Nance SL, Anderson NG, A two-dimensional electrophoretic analysis of the heat-shock-induced proteins of human cells. Clin Chem28:1084-92 1982 |
| PubMed ID: 7200409 |
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| Anderson L, Identification of mitochondrial proteins and some of their precursors in two-dimensional electrophoretic maps of human cells. Proc Natl Acad Sci U S A78:2407-11 1981 |
| PubMed ID: 6941300 |
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| Dolby TW, Devuono J, Croce CM, Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. Proc Natl Acad Sci U S A77:6027-31 1980 |
| PubMed ID: 6777778 |
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| Croce CM, Shander M, Martinis J, Cicurel L, D'Ancona GG, Dolby TW, Koprowski H, Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A76:3416-9 1979 |
| PubMed ID: 114999 |
| Split Ratio |
1:3 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not Inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
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