Description:
TRANSLOCATED CHROMOSOME
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Repository
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NIGMS Human Genetic Cell Repository
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| Subcollection |
Chromosome Abnormalities
DGAP |
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Cell Type
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Fibroblast
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Transformant
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Untransformed
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Race
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White
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Relation to Proband
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proband
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Confirmation
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Karyotypic analysis after cell line submission to CCR
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ISCN
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46,XY,t(4;16)(4pter>4q35::16q22.1> 16qter;16pter>16q22.1::4q35>4qter)
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| Passage Frozen |
2 |
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Chromosome Analysis |
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| Cytogenetics |
Chromosome 16: TRANSLOCATION Breakpoint 16q22 t(4;16)16q22 |
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Chromosome 4: TRANSLOCATION Breakpoint 4q35 t(4;16)4q35 |
| Remarks |
Hydrocephalus, hypospadias, and minor dysmorphic features |
| Callen DF, Baker E, Eyre HJ, Lane SA, An expanded mouse-human hybrid cell panel for mapping human chromosome 16. Ann Genet33:190-5 1990 |
| PubMed ID: 2095701 |
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| Callen DF, Baker EG, Lane SA, Re-evaluation of GM2346 from a del(16)(q22) to t(4;16)(q35;q22.1). Clin Genet38:466-468 1990 |
| PubMed ID: 2289320 |
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| Taysi K, Fishman M, Sekhon GS, A terminal long arm deletion of chromosome 16 in a dysmorphic infant: 46,XY,del(16) (q22). Birth Defects Orig Artic Ser14:343-7 1978 |
| PubMed ID: 728588 |
| Passage Frozen |
2 |
| Split Ratio |
1:4 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
trypsin-EDTA |
| Supplement |
- |
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