GM10341
LCL from B-Lymphocyte
Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
Repository
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NIGMS Human Genetic Cell Repository
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Subcollection |
Old Order Amish Major Affective Disorder Heritable Diseases |
Class |
Disorders of the Nervous System |
Biopsy Source
|
Peripheral vein
|
Cell Type
|
B-Lymphocyte
|
Tissue Type
|
Blood
|
Transformant
|
Epstein-Barr Virus
|
Sample Source
|
LCL from B-Lymphocyte
|
Race
|
White
|
Ethnicity
|
AMISH
|
Family Member
|
46
|
Confirmation
|
Clinical summary/Case history
|
Species
|
Homo sapiens
|
Common Name
|
Human
|
Remarks
|
|
IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
|
Remarks |
Clinically affected; type I bipolar disorder (BPI); onset at age 17; hospitalization at age 18 with both depression and manic symptoms; numerous somatic complaints; brother of GM10343; both daughters diagnosed BPI as well as several siblings |
Ginns EI, Ott J, Egeland JA, Allen CR, Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Falls KM, Keith TP, Paul SM, A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet12:431-5 1996 |
PubMed ID: 8630500 |
|
Pauls DL, Gerhard DS, Lacy LG, Hostetter AM, Allen CR, Bland SD, LaBuda MC, Egeland JA, Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110. Genomics11:730-6 1991 |
PubMed ID: 1774072 |
Split Ratio |
1:3 |
Temperature |
37 C |
Percent CO2 |
5% |
Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
Serum |
15% fetal bovine serum Not Inactivated |
Substrate |
None specified |
Subcultivation Method |
dilution - add fresh medium |
Supplement |
- |
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