The third leading cause of death in the United States, Stroke is an acute neurological event leading to death of neural tissues. Although the majority of strokes are ischemic strokes, meaning there is oxygen deprivation to the brain, almost 20% of strokes are hemorrhagic, resulting from bleeding into the brain. Stroke is a complex disorder and likely multigenic in nature, resulting from a combination of genetic and environmental factors. These well characterized risk factors that contribute to the incidence of stroke include hypertension, cardiac disease, sickle cell disease, hyperhomocysteinemia, family history of stroke and smoking.

The NINDS Cell and DNA repository includes subjects with different types of stroke including ischemic, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, unruptured intracranial aneuryism, silent cerebral infarction, and vascular cognitive impairment. Also included in the collection are affected blood relatives and unaffected blooded relatives of those proband subjects, spouses (spousal controls), and normal healthy individuals (including population and convenience controls).

Cerebrovascular Disease Sample Catalog

• Samples by diagnosis
• Samples by family
• Samples with mutations that cause CVD
• CVD subjects that tested wild-type for known genes
• Samples in DNA Panels
• Unaffected primary blood relatives of individuals with CVD
• Download Phenotypic Data      
• Acknowledgement Guidelines

• Order Form  
• Material Transfer Agreement  
• Statement of Research Intent  

• Required Clinical Data Elements for subjects with Cerebrovascular Disease (CDEs)     
• Clinical Data Elements (CDEs) for Cerebrovascular Disease Data Dictionary  
• Clinical Data Elements (CDEs) for Controls      
• Clinical Data Elements (CDEs) for Controls Data Dictionary  
• Spetzler-Martin Grading Score (for AVM)   

Links

• Federal Policy for the Protection of Human Subjects
• Impracticability of informed consent in the Registry of the Canadian Stroke Network.
• American Stroke Association is the division of the American Heart Association that"s solely focused on reducing disability and death from stroke through research, education, fundraising and advocacy.
• Internet Stroke Center exists to advance understanding of stroke research and clinical care. Their goal is to provide current, professional, un-biased information about stroke. The information on the site is obtained from published accounts, meeting presentations, internet searches, and direct correspondence.
• National Stroke Association"s mission is to reduce the incidence and impact of this life-threatening medical condition. The mission is to save lives, improve quality of care and increase patient outcomes.
• NetWellness provides the highest quality health information and education services created and evaluated by the faculty at the University of Cincinnati, the Ohio State University, and Case Western Reserve University.
• Neuroscience Institute is a regional neuroscience center of excellence based at The University Hospital in Cincinnati, Ohio. The Neuroscience Institute offers comprehensive, compassionate, specialized care for patients with diseases or disorders of the brain and nervous system. Developed by The University Hospital and its neuroscience physicians, The Neuroscience Institute is supported by first class clinical facilities, internationally renowned physicians and scientists with expertise in a variety of neuroscience specialties, and nationally recognized education and research programs. Together, they are working to unlock the mysteries of the human brain and provide an unparalleled level of neuroscience care.
• NINDS Stroke Information Page