Panel Contributors
All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. John Hardy, Andrew Singleton, Michael S. Okun, Ronald Mandel, John Werner, James Meschia, Scott Silliman, Petra Kaufmann, and Catherine Lomen-Hoerth. Brief Description
This panel contains 5 micrograms of DNA/well from 92 unique and unrelated White individuals without neurological disorders. Of these, 38 are males and 54 females, with an age range from 55-88 years. All are from the continental United States. Four wells remain empty for additional laboratory controls. NDPT084 replaces NDPT002 and has all of the same samples, except: ND11416 replaces ND01096, ND02200 replaces ND01568, and ND10909 replaces ND01708.
Data collected on these subjects consisted of Control Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. These data elements were developed in order to be consistent with other NIH healthy control sample collections including that of the National Institute on Aging Late Onset Alzheimer's Disease Consortium (LOAD). These data include a detailed medical and family history, and in many cases a Folstein Mini-Mental Status examination score.
Briefly, all underwent a detailed medical history interview. None have a history of neurological illness in themselves. All were asked specifically regarding the following disorders, which were not present: Alzheimer's, amyotrophic lateral sclerosis, ataxia, bipolar disorder, brain aneurysm, dementia, dystonia, epilespsy, multiple sclerosis, schizophrenia, and Parkinson's. Folstein Mini-mental status examination (MMSE) testing was done on 43 of these individuals, and the score range is from 26/30-30/30.
All were interviewed for family history in detail. None have a family history of any first degree relative with any of the following disorders: amyotrophic lateral sclerosis, ataxia, autism, brain aneurysm, dystonia, epilepsy, multiple sclerosis, and Parkinson's.
Publications
Please cite the panel number and the NINDS repository in any publications, and share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel.
Other Healthy Controls, Positive Controls
Additional control samples from individuals without neurological disease themselves, and with a range of clinical data, is available via the NINDS Repository catalogue. Single samples from this panel can also be obtained, individually.