Coriell Institute for Medical Research
Catalog ID: NDPT090

Brief Description
This panel contains 5 micrograms of DNA/well from 91 unique and unrelated White individuals without neurological disorders. Of these, 32 are males and 59 females, with an age range at collection from 19-38 years. All are from North America. The specific position on the plates are provided as a PDF file. Four wells remain empty for additional laboratory controls. NDPT090 replaces NDPT019 and has the same samples except the following samples have been removed: ND08964, ND09780, ND10058, ND10280, ND10481, ND10495, ND10867, ND08986, ND10343, ND09727, ND02433, ND09305, ND09893, ND10299, ND08500, ND08501, and ND9964. These have been replaced with: ND11622, ND12953, ND01057, ND10601, ND11061, ND12595, ND13305, ND13333, ND14032, ND14128, ND14298, ND14003, ND11191, ND14519, ND12146, and ND11298. As an internal control, ND14003 appears twice on the panel, in B01 and well D11.

Data collected on these subjects consisted of Control Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. These data elements were developed to be consistent with other NIH healthy control sample collections including that of the National Institute on Aging Late Onset Alzheimer's Disease Consortium (LOAD). These data include a detailed medical and family history.

Data regarding demographics, medical history, examination, and family history for these individuals are available as an Excel file. None of the subjects on the panel have a history of neurological illness in themselves. All were asked specifically regarding the following disorders, which were not present: Alzheimer's, amyotrophic lateral sclerosis, ataxia, autism, bipolar disorder, cerebrovascular disease, dementia, dystonia, Parkinson’s, and schizophrenia. None have any first degree relative with a known primary neurological disorder. Specifically none have a family history of any first degree relative with any of the following disorders: amyotrophic lateral sclerosis, ataxia, autism, cerebrovascular disease, dystonia, Parkinson's, schizophrenia.

All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. Russell Buono, Eric Sorenson, Petra Kaufman, David Simon, Daniel Newman, Micheline Gravel, Catherine Lomen-Hoerth, John Hardy, Kapil Sethi, Kevin Boylan, Nickolas Maragakis, Peter Bosch, Ray Watts, Robert Brown, Paul Gordon, Terry Scattergood, Melissa Hanson, Anthony Crawley, Edward Kasarskis, Okun Mandel, David Coffey, Rup Tandan, Robert Hamill, Frederick Wooten, Richard Bedlack, Erik Pioro, David Walk, Kimberly Goslin, Ghazala Hayat, Zachary Simmons, Tulio Bertorini, Kourosh Rezania, Robert Miller, Alan Pestronk, John Hardy, and Andrew Singleton.

Please cite the panel number and the NINDS Repository in any publications, and kindly share those references with the NINDS Repository Management Team at Coriell ( Portions or all of this statement may be used in publications relevant to this panel.

Other Healthy Controls, Positive Controls
Additional control samples from individuals without neurological disease and with a range of clinical data are available via the NINDS Repository catalogue. Single samples from this panel can also be obtained, individually. Positive control samples for known causal genes are available, as listed, under specific disorders (see NINDS Repository catalog).

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