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NA11943 DNA from Somatic cell hybrid

Description:

CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS

Affected:

No Data

Sex:

No Data

Age:

No Data

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Hybrids
Quantity 0.050mg
Quantitation Method Please see our FAQ
Cell Type Somatic cell hybrid
Transformant Untransformed
Sample Source DNA from Somatic cell hybrid
Confirmation Clinical summary/Case history
ISCN Mouse/human hybrid retaining a human der(11) chromosome & human #4, 5, 6, 7, 10, 13, 14, & X
Remarks Line POR4; produced by the fusion of human fibro, GM04613, 46,XY,t(2;11)(p11; p13) with HPRT-deficient mouse RAG cells; grown in medium without selection; retains human der(11)t(2;11) in 92% of cells & other human chromosomes

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 
GENE MAPPING & DOSAGE STUDIES - CHROMOSOME 2 DNA from this somatic cell hybrid gave a positive result in Southern blot hybridization analysis with a probe for 2p25, D2S1, and gave a negative result with a probe for 2q37, D2S3. PCR analysis of DNA from this somatic cell hybrid gave positive results with primers for 2p13, TGFA, and 2p23, POMC, and gave negative results with primers for 2q13, IL1A, and 2q37, ALPP.
 
GENE MAPPING & DOSAGE STUDIES - CHROMOSOME 4 DNA from this somatic cell hybrid gave a positive result in Southern blot hybridization analysis with a probe for 4p16.2p15.1, D4S20.
 
GENE MAPPING & DOSAGE STUDIES - CHROMOSOME 11 DNA from this somatic cell hybrid gave a negative result in Southern blot hybridization analysis with a probe for 11p15.5, D11S12, and gave a positive result with a probe for 11q23.3, ETS1. PCR analysis of DNA from this somatic cell hybrid gave positive results with primers for 11p13, CAT, and 11q21-q22, CLG.
 
GENE MAPPING & DOSAGE STUDIES - CHROMOSOME 16 DNA from this somatic cell hybrid gave negative results in Southern blot hybridization analyses with probes for 16q13q22.1, MT2, and 16pterp13, D16S36.
 

Phenotypic Data

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Remarks Line POR4; produced by the fusion of human fibro, GM04613, 46,XY,t(2;11)(p11; p13) with HPRT-deficient mouse RAG cells; grown in medium without selection; retains human der(11)t(2;11) in 92% of cells & other human chromosomes

Publications

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Leek J, Lench N, Maraj B, Bailey A, Carr IM, Andersen S, Cross J, Whelan P, MacLennan KA, Meredith DM, Prostate-specific membrane antigen: evidence for the existence of a second related human gene British journal of cancer72:583-8 1995
PubMed ID: 7669565
 
Junien C, van Heyningen V, Evans G, Little P, Mannens M, Report of the second chromosome 11 workshop. Genomics12:620-5 1992
PubMed ID: 1348491
 
Bickmore WA, Porteous DJ, Christie S, Seawright A, Fletcher JM, Maule JC, Couillin P, Junien C, Hastie ND, van Heyningen V, CpG islands surround a DNA segment located between translocation breakpoints associated with genitourinary dysplasia and aniridia. Genomics5:685-93 1989
PubMed ID: 2556343
 
Bickmore W, Christie S, van Heyningen V, Hastie ND, Porteous DJ, Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers. Nucleic Acids Res16:51-60 1988
PubMed ID: 2829125
 
Seawright A, Fletcher JM, Fantes JA, Morrison H, Porteous DJ, Li SS, Hastie ND, Van Heyningen V, Analysis of WAGR deletions and related translocations with gene- specific DNA probes, using FACS-selected cell hybrids. Somat Cell Mol Genet14:21-30 1988
PubMed ID: 2829363
 
Porteous DJ, Bickmore W, Christie S, Boyd PA, Cranston G, Fletcher JM, Gosden JR, Rout D, Seawright A, Simola KO, et al, HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13. Proc Natl Acad Sci U S A84:5355-9 1987
PubMed ID: 3037545

External Links

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dbSNP dbSNP ID: 11662
Pricing
International/Commercial/For-profit:
$449.00USD
U.S. Academic/Non-profit/Government:
$263.00USD
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