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AG07671 Fibroblast from Skin, Arm

Description:

ALZHEIMER DISEASE, FAMILIAL, TYPE 3

Affected:

Yes

Sex:

Male

Age:

44 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Canadian Alzheimer Disease
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source Fibroblast from Skin, Arm
Race White
Ethnicity CANADIAN
Family Member 78
Relation to Proband VIII-17
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The donor was clinically affected with Alzheimer's disease. The onset of the disease occurred at age 49. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 6/27/84 using explants of minced skin. The cell morphology is fibroblast-like. The karyotype is 46,XY; normal diploid male. Culture was frozen at PDL 9. A lymphoblast culture from same donor is AG07670. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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PDL at Freeze 4.93
Passage Frozen 8
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks The donor was clinically affected with Alzheimer's disease. The onset of the disease occurred at age 49. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 6/27/84 using explants of minced skin. The cell morphology is fibroblast-like. The karyotype is 46,XY; normal diploid male. Culture was frozen at PDL 9. A lymphoblast culture from same donor is AG07670. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Parshad RP, Sanford KK, Price FM, Melnick LK, Nee LE, Schapiro MB, Tarone RE, Robbins JH, Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc Natl Acad Sci U S A93:5146-50 1996
PubMed ID: 8643543
 
St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al, The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science235:885-90 1987
PubMed ID: 2880399
 
Nee LE, Polinsky RJ, Eldridge R, Weingartner H, Smallberg S, Ebert M, A family with histologically confirmed Alzheimer's disease. Arch Neurol40:203-8 1983
PubMed ID: 6600923

External Links

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dbSNP dbSNP ID: 15731
NCBI GTR 607822 ALZHEIMER DISEASE 3; AD
OMIM 607822 ALZHEIMER DISEASE 3; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL, TYPE 3; AD3

Culture Protocols

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Cumulative PDL at Freeze 8
Passage Frozen 8
Split Ratio 1:2
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not inactivated
Substrate None specified
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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