Two new lines of induced pluripotent stem cells are now available to researchers through the National Institute on Aging’s Aging Cell Repository, housed and distributed by the Coriell Institute for Medical Research. The addition of these two lines brings the total number of highly-characterized iPSC lines offered through this collection to five.
The new iPSC lines were reprogrammed in Coriell’s stem cell laboratory and were sourced from a fibroblast line derived from normal tissue and a line representing Werner syndrome, a rare genetic disease resulting in premature aging.
Induced pluripotent stem cells offer researchers unique and valuable opportunities in studying disease as these cells can become any type of cell in the body through controlled differentiation. As such, these stem cells can give scientists access to biological materials – living neuronal cells for example – which have historically been difficult or impossible to acquire.
Since 2017, the Aging Cell Repository has added two iPSC lines which were reprogrammed from Alzheimer disease cell lines and one from a Hutchinson-Gilford progeria syndrome cell line.
About the Coriell Institute for Medical Research
The Coriell Institute is a global leader in understanding how our personal genomes affect our health. Coriell is recognized as one of the world's leading biobanks, distributing biological samples and offering research and biobanking services to scientists in 85 countries around the globe. Coriell is the trusted steward of world-renowned collections for the National Institutes of Health, disease foundations and commercial clients. Coriell established its reputation as a leader in personalized medicine through the creation of the Coriell Personalized Medicine Collaborative, a research study which investigated the clinical utility of genomic information. Scientists at Coriell are now leveraging their expertise in genomics to develop new tools to prevent and treat opioid use disorder. The Institute is also unlocking the promise of induced pluripotent stem cells and their role in disease research and drug discovery. For more information, visit www.coriell.org, like Coriell on Facebook or follow @Coriell_Science on Twitter.
